27 research outputs found
diagnostic and therapeutic potential
Get PDFΒιβλιογραφία : σ. 24-33Sortilin, also known as neurotensin receptor-3, is a member of the Vps10p domain receptors family, and it was first discovered in the human brain. It mainly acts as a receptor or a co-receptor for protein trafficking in the secretory pathway by interacting with neurotrophins. It initiates cell survival and apoptosis signals. Sortilin deregulation is partly responsible for the development of several disorders, including neurological diseases and many different types of cancer. This research is focused on lung cancer, which is the most common cause of cancer-related deaths. Sortilin, not only stimulates tumors growth, but it may also serve as a marker for prognosis, early diagnosis and the improvement of the existing therapeutic treatments. The examination and analysis of lung cancer for particular abnormalities associated with sortilin will expand the knowledge of the pulmonary oncologic pathologists, who will determine predictive biomarkers for lung cancer targeted therapies. Immunotherapy is also a clinical validate way of cancer treatment, although its strategies need further investigation to become effective and less risky.33 σ
Do lifestyle factors affect clinical outcomes following total knee replacement? An integrated qualitative study exploring the perceptions and experiences of participants in the PRO Knee feasibility cohort study.
Get PDFThe development of pre-operative interventions to improve clinical outcomes following total knee replacement surgery has been identified as a research priority. In the first step of a programme of research, we conducted a feasibility cohort study, which investigated the effect of modifiable lifestyle factors, including alcohol consumption, smoking, physical inactivity and living with overweight, on clinical outcomes following total knee replacement (PRO Knee). Alongside PRO Knee, we conducted an integrated qualitative study to understand the acceptability of the methods used in the PRO Knee study and to explore the experiences of patients waiting for total knee replacement surgery, along with their beliefs and experiences regarding lifestyle interventions. Adult patients awaiting total knee replacement surgery, who had consented to participate in the PRO Knee study were eligible to participate. Semi structured interviews were conducted with all patients who provided informed consent for the qualitative study. Interviews were audio-recorded; transcribed in an intelligent verbatim format and data were analysed using the Framework Method. Ten participants (9 female, 1 male) were recruited (average age 70, range 56-88) and all interviews were conducted over the telephone. The recruitment and data collection processes of the PRO Knee study were acceptable to participants. Five further themes relating to the lived experience of waiting for and undergoing total knee replacement surgery were identified: 1) Osteoarthritis of the knee and co-morbidity; 2) The decision to have surgery; 3) Waiting for total knee replacement; 4) Lifestyle conversations and interventions; 5) Recovery from total knee replacement. The burden of living with osteoarthritis of the knee was significant and participants had often experienced multiple unsuccessful interventions. Participants could recall lifestyle conversations, which they were open to, but were not offered support. Most participants were positive about participating in lifestyle interventions prior to surgery. The participants who had poor outcomes were left with intrusive pain, and feelings of regret. The recruitment and data collection processes for the PRO-Knee feasibility cohort study were acceptable to participants and further study in this area is now warranted. [Abstract copyright: © 2026. The Author(s).
Do lifestyle factors affect clinical outcomes following total knee replacement? An integrated qualitative study exploring the perceptions and experiences of participants in the PRO Knee feasibility cohort study
No full textThe development of pre-operative interventions to improve clinical outcomes following total knee replacement surgery has been identified as a research priority. In the first step of a programme of research, we conducted a feasibility cohort study, which investigated the effect of modifiable lifestyle factors, including alcohol consumption, smoking, physical inactivity and living with overweight, on clinical outcomes following total knee replacement (PRO Knee). Alongside PRO Knee, we conducted an integrated qualitative study to understand the acceptability of the methods used in the PRO Knee study and to explore the experiences of patients waiting for total knee replacement surgery, along with their beliefs and experiences regarding lifestyle interventions. Adult patients awaiting total knee replacement surgery, who had consented to participate in the PRO Knee study were eligible to participate. Semi structured interviews were conducted with all patients who provided informed consent for the qualitative study. Interviews were audio-recorded; transcribed in an intelligent verbatim format and data were analysed using the Framework Method. Ten participants (9 female, 1 male) were recruited (average age 70, range 56-88) and all interviews were conducted over the telephone. The recruitment and data collection processes of the PRO Knee study were acceptable to participants. Five further themes relating to the lived experience of waiting for and undergoing total knee replacement surgery were identified: 1) Osteoarthritis of the knee and co-morbidity; 2) The decision to have surgery; 3) Waiting for total knee replacement; 4) Lifestyle conversations and interventions; 5) Recovery from total knee replacement. The burden of living with osteoarthritis of the knee was significant and participants had often experienced multiple unsuccessful interventions. Participants could recall lifestyle conversations, which they were open to, but were not offered support. Most participants were positive about participating in lifestyle interventions prior to surgery. The participants who had poor outcomes were left with intrusive pain, and feelings of regret. The recruitment and data collection processes for the PRO-Knee feasibility cohort study were acceptable to participants and further study in this area is now warranted. [Abstract copyright: © 2026. The Author(s).
Analysis of Core-Shell Leaky-Wave Lens Antennas based on a combination of Physical Optics and Asymptotic Techniques
No full textIn the framework of this MSc thesis the analysis of core-shell leaky-wave lens antennas is presented, based on a combination of asymptotic and Physical Optics techniques. This study aims to develop an analysis approach which can be subsequently used for the optimization of the Fly’s Eye antenna concept, through enabling the investigation of shaped variations of the core lens. The main difficulty of this prospect refers to the surface of the core lens being in the near field of the leaky wave feeding structure, since the evaluation of the near field is in general a computationally inefficient process. Adhering to this conclusion, a big part of this thesis elaborates on a very fast approach for the derivation of the near field, through asymptotically approximating the involved integral expressions. More specifically, the presented method exploits the nature of the near field in the examined stratification through introducing an approximation in the integral expressions, which in turn enables their asymptotic evaluation in a straightforward manner. Subsequently, the near field on the core lens is combined with a set of Physical Optics techniques in order to develop a model for the integrated lens architecture of the Fly’s Eye antenna. Modelling the core-shell structure in such a manner enables its study in a much more computationally efficient fashion compared to the use of a full-wave simulator. In addition, it facilitates the investigation of structural alterations in the antenna concept, like shaped variations of the core lens. The derived model presented in this thesis also contributed to the measurement campaign of the Fly’s Eye antenna prototype, through identifying a problematic component in the assembled prototype.Electrical Engineerin
Do lifestyle factors affect clinical outcomes following total knee replacement? An integrated qualitative study exploring the perceptions and experiences of participants in the PRO Knee feasibility cohort study
No full textBackground
The development of pre-operative interventions to improve clinical outcomes following total knee replacement surgery has been identified as a research priority. In the first step of a programme of research, we conducted a feasibility cohort study, which investigated the effect of modifiable lifestyle factors, including alcohol consumption, smoking, physical inactivity and living with overweight, on clinical outcomes following total knee replacement (PRO Knee). Alongside PRO Knee, we conducted an integrated qualitative study to understand the acceptability of the methods used in the PRO Knee study and to explore the experiences of patients waiting for total knee replacement surgery, along with their beliefs and experiences regarding lifestyle interventions.
Methods
Adult patients awaiting total knee replacement surgery, who had consented to participate in the PRO Knee study were eligible to participate. Semi structured interviews were conducted with all patients who provided informed consent for the qualitative study. Interviews were audio-recorded; transcribed in an intelligent verbatim format and data were analysed using the Framework Method.
Results
Ten participants (9 female, 1 male) were recruited (average age 70, range 56–88) and all interviews were conducted over the telephone. The recruitment and data collection processes of the PRO Knee study were acceptable to participants. Five further themes relating to the lived experience of waiting for and undergoing total knee replacement surgery were identified: 1) Osteoarthritis of the knee and co-morbidity; 2) The decision to have surgery; 3) Waiting for total knee replacement; 4) Lifestyle conversations and interventions; 5) Recovery from total knee replacement.
The burden of living with osteoarthritis of the knee was significant and participants had often experienced multiple unsuccessful interventions. Participants could recall lifestyle conversations, which they were open to, but were not offered support. Most participants were positive about participating in lifestyle interventions prior to surgery. The participants who had poor outcomes were left with intrusive pain, and feelings of regret.
Conclusion
The recruitment and data collection processes for the PRO-Knee feasibility cohort study were acceptable to participants and further study in this area is now warranted
Do Lifestyle Factors affect patient reported clinical outcomes after total knee replacement surgery? A feasibility cohort study
Get PDFAimsTo evaluate the feasibility of a substantive cohort study to determine whether modifiable lifestyle factors, including smoking, physical inactivity, alcohol consumption and being overweight, affect patient-reported clinical outcomes after total knee replacement surgery.MethodsAdults awaiting total knee replacement surgery were recruited pre-operatively and completed self-reported questionnaires at baseline and 3- and 6-months post-surgery. Feasibility outcomes, including recruitment, retention and response rate of the primary outcome questionnaire were analysed descriptively.Results40 participants were recruited from 183 eligible patients (22%). 87.5% (35/40) participants returned questionnaires at 6-months. 85% (34/40) of participants were overweight (BMI>24.9), 25% (10/40) drank alcohol (AUDIT-C > 4), 5% (2/40) smoked tobacco and 67.5% (27/40) were physically inactive (GPAQ classification of ‘moderately inactive’, or ‘inactive’). ConclusionModifiable lifestyle factors including smoking, alcohol use, physical inactivity and being overweight are highly prevalent in patients waiting for total knee replacement. Based on this study, a future substantive cohort study investigating the effect of lifestyle factors on clinical outcomes post total knee replacement in the UK NHS is feasible
Establishing the relevancy of the bookkeeping libraries to the functional testing of computer implementations
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Law's humility ::enlarging the scope of jurisprudential disagreement /
No full text"This book invites newcomers to analytical legal philosophy to reconsider the terms in which they are accustomed to describing and defending their jurisprudential allegiances. It argues that familiar taxonomic labels such as legal positivism, natural law theory and legal interpretivism are poor guides to the actual diversity of views on the nature and normativity of law, mainly because they fail to carve up the reality of jurisprudential disagreement at its joints. These joints, the author suggests, are elusive because the semantics of law systematically misplaces them. Their true nature resides in the metaontological and metanormative features that dictate or indicate the target of a theory's jurisprudential commitments. The book advocates a new vocabulary for articulating these commitments without eliminating the use of familiar criteria of division among competing theories of law. The resulting picture is a much broader platform of meaningful disagreement about the nature and grounds of legal truth and legal normativity. Albeit based on a factualist-cognitivist understanding of the sources and grounds of law, the book reserves ample room for the unconvinced. Those suspicious of the project of "ontologising" theoretical disagreements in law can avail themselves of the quietist or anti-metaphysical avenue that the book's alternative taxonomy also makes available. The humblest path to law's reality may not be metaphysically ambitious after all"-
Real and future threats and EU as a global security actor
No full textThe aim of this PhD thesis was to analyze and asses EU’s performance as a global security actor in cases of new and future threats. Through the comparative analysis and assessment of EU policies and initiatives for the prevention, management and counter of climate change and migration security effects and also radicalization and terrorism the author pointed that EU could act as a distinct and effective security actor in new threats. From the angle of methodology the author uses the framework of Performance of Blavoukos and Bourantonis in parallel with an innovative methodological tool of eleven indicators- parameters.Η διατριβή εξετάζει την επίδοση της Ε.Ε. ως παγκόσμιου δρώντα ασφάλειας σε περιπτώσεις νέων και δυνητικών απειλών. Μέσω της συγκριτικής ανάλυσης και αξιολόγησης της πολιτικής της Ε.Ε. για την πρόληψη, τη διαχείριση και την αντιμετώπιση των επιπτώσεων της κλιματικής αλλαγής και τη μετανάστευσης, καθώς και της ριζοσπαστικοποίησης και της τρομοκρατίας αποδεικνύεται πως η Ένωση μπορεί να αποτελέσει τον ιδανικό παγκόσμιο δρώντα ασφάλειας σε περιπτώσεις νέων απειλών. Μεθοδολογικά γίνεται αξιοποίηση του πλαισίου μέτρησης της επίδοσης των Μπλαβούκου- Μπουραντώση σε συνδυασμό με ένα καινοτομικό μεθοδολογικό εργαλείο έντεκα δεικτών- παραμέτρων
