131,960 research outputs found
Dog coursing meet at Kearney, Nebraska
No full textNote: The photographers caption reads 'Miss Liddle and Pathfinder in slips for finale. Pathfinder won.
A regional regime? : regeneration in the North East of England
No full textThis dissertation is set in the North East (NE) of England and demonstrates how an experimental form of elite governance, characterised by multi-level, intra and inter-agency negotiation and co-ordination developed within complex and ambiguous socio-political structures and traditional hierarchies to deal with unmet social and economic needs. This emergent form of entrepreneurial governance has resulted from a poorly institutionalised field of regeneration, and allowed elites to seek autonomy by adapting national policies to specifically regional projects. A top-down, managerialist form of governance, it is not entirely democratic or open to public participation, but strategically contingent on global and other constraints. Central to an understanding of regeneration is the way strategies are formulated and implemented.
This regime, with a broader mix of enterprising public servants and politically minded business and other interests, has coalesced over a long period to respond entrepreneurially to the consequences of globalisation and uneven development, and the failure of national and regional policies. A legacy of decline has created a strategic, cohesive and identifiably exclusive regime of actors, who act in the region’s interests.
This regime is unlike the static or re-constructive regimes prevalent in other regions, rather it blends the positive aspects of traditional regional decision making with a more innovative approach. Democratic forms of managing regional space have gradually been replaced by a more adaptable and flexible form more suited to modern day and future needs. Power and influence shift dynamically over time, space and initiative, activities are legitimised by absorbing state officials into activities, and being in close proximity to civic society. As part of the history of change, and embedded in the social system, elites interact formally and informally
Distal Tubulopathy. Liddle Syndrome
No full textThe clinical recommendations on management of children with Liddle syndrome which is characterized by severe hypertension along with low activity levels of renin and aldosterone in blood plasma, hypokalemia and metabolic alkalosis, were developed by the experts of the Union of pediatricians of Russia. Aspects of epidemiology, etiology and pathogenesis, disease progression, differential diagnostics and evidence-based treatment are presented
Abide with me [music] : sacred song /
No full textH. 1600 (Publisher number). No. 2 in D-flat. For voice and piano. Includes part for organ.; Cover title.; Pl. no.: H. 1600.; "No. 2 in D-flat".; Also available online http://nla.gov.au/nla.mus-vn3551312
Bayesian experimental design and model selection forecasting
No full textIntroduction Common applications of Bayesian methods in cosmology involve the computation of model probabilities and of posterior probability distributions for the parameters of those models. However, Bayesian statistics is not limited to applications based on existing data, but can equally well handle questions about expectations for the future performance of planned experiments, based on our current knowledge. This is an important topic, especially with a number of future cosmology experiments and surveys currently being planned. To give a taste, they include: large-scale optical surveys such as Pan-STARRS (Panoramic Survey Telescope and Rapid Response System), DES (the Dark Energy Survey) and LSST (Large Synoptic Survey Telescope), massive spectroscopic surveys such as WFMOS (Wide-Field Fibrefed Multi-Object Spectrograph), satellite missions such as JDEM (the Joint Dark Energy Explorer) and EUCLID, continental-sized radio telescopes such as SKA (the Square Kilometer Array) and future cosmic microwave background experiments such as B-Pol searching for primordial gravitational waves. As the amount of available resources is limited, the question of how to optimize them in order to obtain the greatest possible science return, given present knowledge, will be of increasing importance. In this chapter we address the issue of experimental forecasting and optimization, starting with the general aspects and a simple example. We then discuss the so-called Fisher Matrix approach, which allows one to compute forecasts rapidly, before looking at a real-world application. Finally, we cover forecasts of model comparison outcomes and model selection Figures of Merit
Challenges in diagnosing and treating Liddle syndrome in resource-limited settings: A case report from Indonesia
No full textLiddle syndrome, a rare form of monogenic hypertension, poses significant diagnostic and therapeutic challenges due to its phenotypic variability and the need for genetic testing. The rarity of the condition, coupled with the limited availability of first-line treatments such as epithelial sodium channel (ENaC) blockers, makes this case report particularly urgent and novel, highlighting alternative management strategies in resource-limited settings. The aim of this case report was to present the diagnostic challenges, therapeutic strategies, and clinical outcomes of a patient with Liddle syndrome who did not have access to ENaC blockers, emphasizing the importance of early recognition and personalized treatment. A 35-year-old female presented with resistant hypertension (190/100 mmHg) and bilateral limb weakness. Laboratory results revealed persistent hypokalemia, hypernatremia, and metabolic alkalosis. Low aldosterone levels, alongside clinical and family history, led to the diagnosis of Liddle syndrome. Genetic testing was not conducted due to resource limitations, and ENaC blockers were unavailable. The patients were managed with a combination of alternative antihypertensive agents, potassium supplementation, and a low-sodium diet. Although this approach led to modest improvements in blood pressure and motor strength, persistent hypokalemia and hypernatremia underscored the suboptimal control of the syndrome's underlying pathophysiology in the absence of ENaC blockers. This case highlights the challenges faced in resource-limited settings and the need for innovative strategies to manage rare conditions like Liddle syndrome. Liddle syndrome's diagnostic and therapeutic challenges underscore the critical importance of early recognition and access to targeted therapies. In the absence of ENaC blockers, alternative treatment strategies can provide some benefit, but they often fall short of optimal management. This case emphasizes the need for enhanced clinical awareness, improved access to genetic testing, and the development of personalized treatment approaches to achieve better patient outcomes
Abide with me [music] : sacred song /
No full textH.1600 (Publisher number). For voice and piano.; "No.1 in D-flat".; "Dedicated to and sung by Miss Clara Butt".; Pl. no.: H.1600.; Also available online http://nla.gov.au/nla.mus-an6618752; MUS: N, -
Home song [music] /
No full textH. 1697 (Publisher number). Cover title.; For voice and piano.; "No. 1 in D-flat".; "Sung by Miss Ada Crossley".; Pl. no.: H. 1697.; Also available online http://nla.gov.au/nla.mus-an22253143
Abide with me [music] : sacred song /
No full textH. 1600 (Publisher number). For voice and piano.; "Dedicated to and sung by Miss Clara Butt".; No. 2 in D-flat.; Pl. no.: H.1711.; Also available online http://nla.gov.au/nla.mus-an12914820
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