3,643 research outputs found
L'ordine liberale: tra crisi e critica
No full textGruppo di brevi recensioni (curate da Stefano De Luca) dei seguenti volumi: Vittorio Emanuele Parsi, Titanic. Il naufragio dell’ordine liberale, Bologna,
Il Mulino, 2018, pp. 220 (autrice Giulia Iacovelli); Sonia Lucarelli, Cala il sipario sull’ordine liberale? Crisi di un sistema che ha cambiato il mondo, Milano, Vita e Pensiero, 2020, pp. 284 (autrice Giulia Iacovelli); G. John Ikenberry, Un mondo sicuro per la democrazia. Internazionalismo liberale e crisi dell’ordine globale, Milano, Vita e Pensiero, 2021, pp. 390 (autore Antonio Campati); Jan Zielonka, Contro-rivoluzione. La disfatta dell’Europa liberale, Roma-Bari, Laterza, 2018, pp. 192 (autore Francesco Romano Fraioli); Jean-Claude Michéa, Il lupo nell’ovile. Diritto, liberalismo, vita comune, Milano, Meltemi, 2020, pp. 142 (autore Francesco Romano Fraioli); Andrea Zhok, Critica della ragione liberale. Una filosofia della storia corrente, Milano, Meltemi, 2020, pp. 374 (autore Giuseppe Sciara); Ivan Krastev, Stephen Holmes, La rivolta antiliberale. Come l’Occidente sta perdendo la battaglia per la democrazia, Milano, Mondadori, 2020, pp. 282 (autore Stefano De Luca); Anne Applebaum, Il tramonto della democrazia: il fallimento della politica e il fascino dell’autoritarismo, Milano, Mondadori, 2021, pp. 158 (autore Stefano De Luca)
Unconventional approaches to diabetes screening: Rejuvenation time for cardiovascular prevention strategies?
No full text
ENDOTHELIAL SIRT6 BLUNTS STROKE SIZE AND NEUROLOGICAL DEFICIT BY PRESERVING BLOOD-BRAIN BARRIER INTEGRITY: A TRANSLATIONAL STUDY
No full textAims: Aging is an established risk factor for stroke; genes regulating longevity are implicated in the pathogenesis of ischaemic stroke where to date, therapeutic options remain limited. The blood-brain barrier (BBB) is crucially involved in ischaemia/reperfusion (I/R) brain injury thus representing an attractive target for developing novel therapeutic agents. Given the role of endothelial cells in the BBB, we hypothesized that the endothelial-specific expression of the recently described longevity gene SIRT6 may exhibit protective properties in stroke.
Methods and results: SIRT6 endothelial expression was reduced following stroke. Endothelial-specific Sirt6 knockout (eSirt6-/-) mice, as well as animals in which Sirt6 overexpression was post-ischaemically induced, underwent transient middle cerebral artery occlusion (tMCAO). eSirt6-/- animals displayed increased infarct volumes, mortality, and neurological deficit after tMCAO, as compared to control littermates. Conversely, post-ischaemic Sirt6 overexpression decreased infarct size and neurological deficit. Analysis of ischaemic brain sections revealed increased BBB damage and endothelial expression of cleaved caspase-3 in eSIRT6-/- mice as compared to controls. In primary human brain microvascular endothelial cells (HBMVECs), hypoxia/reoxygenation (H/R) reduced SIRT6 expression and SIRT6 silencing impaired the barrier function (transendothelial resistance) similar to what was observed in mice exposed to I/R. Further, SIRT6-silenced HBMVECs exposed to H/R showed reduced viability, increased cleaved caspase-3 expression and reduced activation of the survival pathway Akt. In ischaemic stroke patients, SIRT6 expression was higher in those with short-term neurological improvement as assessed by NIHSS scale and correlated with stroke outcome.
Conclusion: Endothelial SIRT6 exerts a protective role in ischaemic stroke by blunting I/R-mediated BBB damage and thus, it may represent an interesting novel therapeutic target to be explored in future clinical investigation
Cicerone, il primo liberale della storia?
No full textHayek interpreta la figura di Cicerone come quella di primo 'liberale' della storia, distaccandosi così dalla visione 'liberale classica', portata avanti da Constant e da Berlin, sul mondo antico come assolutamente 'altro' rispetto alla modernità
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