1,290 research outputs found
Does Apo2LTRAIL play any physiologic role in osteoclastogenesis?
No full textCopyright © 2008 by American Society of HematologyAgatha Labrinidis, Vasilios Liapis, Le M. Thai, Gerald J. Atkins, Cristina Vincent, Shelley Hay, Natalie A. Sims, Andrew C. W. Zannettino, David M. Findlay and Andreas Evdokio
Induction of discrete apoptotic pathways by bromo-substituted indirubin derivatives in invasive breast cancer cells
No full textIndirubin derivatives gained interest in recent years for their anticancer and antimetastatic properties. The objective of the present study was to evaluate and compare the anticancer properties of the two novel bromo-substituted derivatives 6-bromoindirubin-3'-oxime (6BIO) and 7-bromoindirubin-3'-oxime (7BIO) in five different breast cancer cell lines. Cell viability assays identified that 6BIO and 7BIO are most effective in preventing the proliferation of the MDA-MB-231-TXSA breast cancer cell line from a total of five breast cancer cell lined examined. In addition it was found that the two compounds induce apoptosis via different mechanisms. 6BIO induces caspase-dependent programmed cell death through the intrinsic (mitochondrial) caspase-9 pathway. 7BIO up-regulates p21 and promotes G(2)/M cell cycle arrest which is subsequently followed by the activation of two different apoptotic pathways: (a) a pathway that involves the upregulation of DR4/DR5 and activation of caspase-8 and (b) a caspase independent pathway. In conclusion, this study provides important insights regarding the molecular pathways leading to cell cycle arrest and apoptosis by two indirubin derivatives that can find clinical applications in targeted cancer therapeutics.Katerina A. Nicolaou, Vasilis Liapis, Andreas Evdokiou, Constantina Constantinou, Prokopios Magiatis, Alex L. Skaltsounis, Laura Koumas, Paul A. Costeas and Andreas I. Constantino
High-voltage capacitively coupled contactless conductivity detection for conventional and microchip capillary electrophoresis
No full textThis thesis focuses on the optimisation of capacitively coupled contactless conductivity detection for capillary and microchip electrophoresis and its applications in analytical chemistry. First, the effect of high excitation voltages and operation frequencies on the capacitively coupled contactless conductivity detector cell for conventional capillary electrophoresis is evaluated. The detector electrodes comprised two steel tubes cut from hypodermic needles, through which the capillaries were inserted. It is demonstrated that increasing excitation voltages from 25 V pp, to 250 Vpp improves the detection limits by a factor of 10. The high actuator voltage approach was also investigated for contactless conductivity detection on a glass-microchip device with ancm long channel. The detector electrodes formed part of the microchip and were placed on the microchip directly above the microchannel. In a separate project the simplification of on-microchip contactless conductivity detection was accomplished. This was achieved by integrating the detector electrodes on to a chip-holder specifically designed for this purpose. Thus the electrodes were a part of the holder, an improvement of the previous arrangement whereby the detector electrodes were situated on the microdevice. Finally the applications and advantages of the optimised high-voltage capacitively coupled contactless conductivity detection for inorganic and organic analysis were demonstrated. The separation and detection of 14 metal ions was accomplished in less than six minutes. The compatibility of this detector with non-UV transparent, polymer capillaries has been demonstrated. The detection of native amino acids has been evaluated. Part of the work was dedicated to the on-chip analysis of various classes of organic ions. The two immunoproteins human immunoglobulin M (IgM) and immunoglobulin G (IgG), were analysed in their unlabelled state on both capillary and lab-on-chip platforms. All species involved in an immunological interaction between IgM and IgG could be detected. A method for the analysis of selected basic pharmaceutical drug substances was developed. Detection limits comparable to those supplied by direct UV detection were obtained. Main component assays of selected pharmaceutical preparations have been demonstrated
Sofic groups and diophantine approximation
No full textWe prove the algebraic eigenvalue conjecture of J. Dodziuk, P. Linnell, V. Mathai, T. Schick, and S. Yates (see [2]) for sofic groups. Moreover, we give restrictions on the spectral measure of elements in the integral group ring. Finally, we define integer operators and prove a quantization of the operator norm below 2. To the knowledge of the author, there is no group known that is not sofic. (c) 2007 Wiley Periodicals, Inc
MIT POŚWIĘCENIA I MIT PRAWDY W SŁOWACKIEJ LITERATURZE PO DRUGIEJ WOJNIE ŚWIATOWEJ (J. C. HRONSKÝ: ANDREAS BÚR MAJSTER AND DOMINIK TATARKA: FARSKÁ REPUBLIKA AND ESSAYS)
No full textHronský’s work was written in Rome at the beginning of his journey until emigration in 1947/48. This, in terms of genre and content, is a distinctive form: an autobiographical tale through which the author erected a memorial. Andreas Búr embodies the capabilities and tragedy of the author. The sacrifice for the people who kill him bears in itself a Christian pathos and at the same time the extinction of everything the author was. His character remains in the memory of the people as the myth of an ethical act. Tatarka’s work was written in Slovakia in 1948. This critique of conventional Christianity, which has tragic consequences for a defenceless woman and her children, is linked with criticism of the author Hronský in the novel Andreas Búr Majster. The movement towards the myth of truth begins in Tatarka immediately at the time of thawing after Stalin’s death in the essay “Démon súhlasu” (The Demon of Conformity) and ends in the author’s 19 years of “life in truth” and the victim of a life without civil rights.Hronský pisał swoje utwory w Rzymie na początku emigracji w latach 1947-1948. Pod kątem gatunku i zawartości jest to odrębna forma: opowieść autobiograficzna, w której autor tworzy memoriał. Andreas Búr jest ucieleśnieniem możliwości i tragedii autora. Poświęcenie za ludzi, którzy go zabijają, samo w sobie ukazuje chrześcijański patos, ale również symbolizuje koniec tego, kim był autor. Jego osoba pozostaje w pamięci jako mit aktu etycznego. Utwory Tatarki zostały napisane w roku 1948 na Słowacji. Jest to krytyka konwencjonalnego chrześcijaństwa o tragicznych konsekwencjach dla bezbronnej kobiety i jej dzieci, nawiązująca do krytyki Hronský’ego jako autora powieści Andreas Búr Majster. Mit prawdy ukazuje się u Tatarki w okresie odwilży zaraz po śmierci Stalina w eseju Démon súhlasu (Demon zgody). Tendencja ta kończy się po 19 latach „życia w prawdzie” i bycia ofiarą życia pozbawionego praw obywatelskich
Pachyprotasis kojimai Taeger & Shinohara, 2017, paratype female (NSMT)
No full textAdditional figures for the paper:Pachyprotasis kojimai sp. nov. — the “Pachyprotasis nigronotata” of Japanese authors (Hymenoptera: Tenthredinidae) by Andreas Taeger, Akihiko Shinohara & Katja Kramp (Zootaxa, 2017)Photos were taken by the first author with a Leica DFC 495 digital camera and a Leica M405 C stereomicroscope. Composite images with an extended depth of field were created from stacks of images using the software CombineZP, and finally arranged and partly enhanced with Ulead PhotoImpact X3. <br
Pachyprotasis simulans (Klug, 1817) from Germany
No full textAdditional figures for the paper:Pachyprotasis kojimai sp. nov.—the “Pachyprotasis nigronotata” of Japanese authors (Hymenoptera: Tenthredinidae) by Andreas Taeger, Akihiko Shinohara & Katja Kramp (Zootaxa, 2017)Photos were taken by the first author with a Leica DFC 495 digital camera and a Leica M405 C stereomicroscope. Composite images with an extended depth of field were created from stacks of images using the software CombineZP, and finally arranged and partly enhanced with Ulead PhotoImpact X3. <br
Pachyprotasis kojimai Taeger & Shinohara, 2017, holotype (NSMT)
No full textAdditional figures for the paper:Pachyprotasis kojimai sp. nov. — the “Pachyprotasis nigronotata” of Japanese authors (Hymenoptera: Tenthredinidae) by Andreas Taeger, Akihiko Shinohara & Katja Kramp (Zootaxa, 2017)Photos were taken by the first author with a Leica DFC 495 digital camera and a Leica M405 C stereomicroscope. Composite images with an extended depth of field were created from stacks of images using the software CombineZP, and finally arranged and partly enhanced with Ulead PhotoImpact X3. <br
Pachyprotasis nigronotata Kriechbaumer, 1874
No full textAdditional figures for the paper:Pachyprotasis kojimai sp. nov.—the “Pachyprotasis nigronotata” of Japanese authors (Hymenoptera: Tenthredinidae) by Andreas Taeger, Akihiko Shinohara & Katja Kramp (Zootaxa, 2017)Photos were taken by the first author with a Leica DFC 495 digital camera and a Leica M405 C stereomicroscope. Composite images with an extended depth of field were created from stacks of images using the software CombineZP, and finally arranged and partly enhanced with Ulead PhotoImpact X3. <br
Pachyprotasis kojimai Taeger & Shinohara, 2017, female paratype (SDEI)
No full textAdditional figures for the paper:Pachyprotasis kojimai sp. nov. — the “Pachyprotasis nigronotata” of Japanese authors (Hymenoptera: Tenthredinidae) by Andreas Taeger, Akihiko Shinohara & Katja Kramp (Zootaxa, 2017)Photos were taken by the first author with a Leica DFC 495 digital camera and a Leica M405 C stereomicroscope. Composite images with an extended depth of field were created from stacks of images using the software CombineZP, and finally arranged and partly enhanced with Ulead PhotoImpact X3. <br
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