6,393 research outputs found
Author Correction: Understanding the role of bitter taste perception in coffee, tea and alcohol consumption through Mendelian randomization
No full textAn amendment to this paper has been published and can be accessed via a link at the top of the paper. The original version of this Article contained an error in the author name Liang-Dar Hwang, which was incorrectly given as Daniel Liang-Dar Hwang
Characterization of the Shank family of synaptic proteins - Multiple genes, alternative splicing, and differential expression in brain and development
No full textShank1, Shank2, and Shank3 constitute a family of proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank directly interacts with GKAP and Homer, thus potentially bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex in synapses (Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, S., Valtschanoff, J., Weinberg, R J., morley, P. F., and Sheng, M. (1999) Neuron 23, 569-582; Tu, J. C., Xiao, B., Naisbitt, S., Yuan, J. P., Petralia, R. S., Brakeman, P., Dean, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., and Worley, P. F. (1999) Neuron 23, 583-592). Shank contains multiple domains for protein-protein interaction including ankyrin repeats, an SH3 domain, a PSD-95/DIg/ZO-1 domain, a sterile a motif domain, and a proline-rich region. By characterizing Shank cDNA clones and RT-PCR products, we found that there are four sites far alternative splicing in Shank1 and another four sites in Shank2, some of which result in deletion of specific domains of the Shank protein. In addition, the expression of the splice variants is differentially regulated in different regions of rat brain during development. Immunoblot analysis of Shank proteins in rat brain using five different Shank antibodies reveals marked heterogeneity in size (120-240 kDa) and differential. spatiotemporal expression. Shank1 immunoreactivity is concentrated at excitatory synaptic sites in adult brain, and the punctate staining of Shank1 is seen in developing rat brains as early as postnatal day 7. These results suggest that alternative splicing in the Shank family may be a mechanism that regulates the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain
A hybrid coarse/fine layered multicast scheme based on hierarchical bandwidth inference congestion control
No full textFast Matching Pursuit Video Coding by Combining Dictionary Approximation and Atom Extraction
No full textMeasurement of ambient vibration by self-mixing interferometry and its application to intrusion detection
No full textWe present a self-mixing interferometer (SMI) vibrometer developed around a laser diode with a simple and compact analog processing of the fringe signal, and show that this instrument can readily detect ambient vibrations—which adversely affect mechanical material-working lathes. In addition, we find out that the vibrometer is an excellent intrusion detector, capable of discovering a man stepping several meters away from the sensor, thus hinting at an SMI application as an antithief sensor
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