12,258 research outputs found
Bai nian si suo
No full textBen shu shi zuo zhe de yi bu sui bi, za wen ji. nei rong bao gua : bai nian si suo, shi ren gang zou, ma shang hui lai, zun zhong shui de wen hua cha yi, yi ben shu de bei hou, shang hai de yi ri, shui bo duo le zhong guo ren sheng qi de quan li, liang li cao mei de hui xuan den
Burmopsylla Liang, Zhang & Liu 2016
No full text3.188 Genus Burmopsylla Liang, Zhang & Liu, 2016 Burmopsylla Liang, Zhang & Liu, 2016: 484. Type species: Burmopsylla maculata Liang, Zhang & Liu, 2016.Published as part of Guo, Mingxia, Xing, Lida, Wang, Bo, Zhang, Weiwei, Wang, Shuo, Shi, Aimin & Bai, Ming, 2017, A catalogue of Burmite inclusions, pp. 249-379 in Zoological Systematics 42 (3) on page 294, DOI: 10.11865/zs.201715, http://zenodo.org/record/536031
Nan Han cong lu
No full text梁廷枏撰.框15.2 x 11.8公分, 8行17字, 白口, 單魚尾, 四單雙邊.綫裝, 一函.Liang Tingnan zhuan.Kuang 15.2 x 11.8 gong fen, 8 hang 17 zi, bai kou, dan yu wei, si dan shuang bian.Xian zhuang, yi han
Burmopsylla maculata Liang, Zhang & Liu 2016
No full text249) Burmopsylla maculata Liang, Zhang & Liu, 2016 Burmopsylla maculata Liang, Zhang & Liu, 2016: 485. Type specimen(s). H (♂): EMTG BU-001053 (EMTG). P (♀): EMTG BU-001056, EMTG BU-001087 (EMTG).Published as part of Guo, Mingxia, Xing, Lida, Wang, Bo, Zhang, Weiwei, Wang, Shuo, Shi, Aimin & Bai, Ming, 2017, A catalogue of Burmite inclusions, pp. 249-379 in Zoological Systematics 42 (3) on page 294, DOI: 10.11865/zs.201715, http://zenodo.org/record/536031
Dan bai zhi jie gou song chi zhi chao sheng ce liang
No full textby Mok Hing-Yim = 蛋白質結構鬆弛之超聲測量 / 莫慶炎.Thesis (M.Phil.)--Chinese University of Hong Kong, 1983.Includes bibliographical references (leaves 76-77).by Mok Hing-Yim = Dan bai zhi jie gou song chi zhi chao sheng ce liang / Mo Qingyan
Liang Bai on the Economic Consequences of the Cultural Revolution
No full textThe Cultural Revolution is a watershed moment in 20th-century Chinese history. Spanning a decade from 1966 to 1976, it constitutes the final years of Mao Zedong’s chairmanship, and shortly precedes the country’s economic liberalization. Intended as a campaign to consolidate the communist revolution of 1949 by “cleansing the class ranks” of “bourgeois elements,” its accompanying violence and chaos is widely believed to have had a major impact on Chinese society. Dr Bai's research project explores the economic consequences of this period, focusing on the rural experience
Liang Bai on the Economic Consequences of the Cultural Revolution
No full textThe Cultural Revolution is a watershed moment in 20th-century Chinese history. Spanning a decade from 1966 to 1976, it constitutes the final years of Mao Zedong’s chairmanship, and shortly precedes the country’s economic liberalization. Intended as a campaign to consolidate the communist revolution of 1949 by “cleansing the class ranks” of “bourgeois elements,” its accompanying violence and chaos is widely believed to have had a major impact on Chinese society. Dr Bai's research project explores the economic consequences of this period, focusing on the rural experience
Identification and Functional Analysis of Two New De Novo KCNMA1 Variants Associated with Liang-Wang syndrome.
No full textAIM
Loss-of-function KCNMA1 variants cause Liang-Wang syndrome (MIM #618729), a newly-identified multiple malformation syndrome with a broad spectrum of developmental and neurological phenotypes. However, the full spectrum of clinical features and underlying pathogenic mechanisms need full elucidation.
METHODS
Exome sequencing was used to identify pathogenic variants. Patch-clamp recordings were performed to access the effects of KCNMA1 variants on BK channels. Total and membrane protein expression levels of BK channels were characterized using Western blotting.
RESULTS
We report identification and functional characterization of two new de novo loss-of-function KCNMA1 variants p.(A172T) and p.(A314T) with characteristics of Liang-Wang syndrome. Variant p.(A172T) is associated with developmental delay, cognitive impairment, and ataxia. Mechanistically, p.(A172T) abolishes BK potassium current, inhibits Mg2+ -dependent gating, but shifts conductance-voltage (G-V) curves to more positive potentials when complexed with WT channels. Variant p.(A314T) is associated with developmental delay, intellectual disability, cognitive impairment, mild ataxia, and generalized epilepsy, suppresses BK current amplitude, and shifts G-V curves to more positive potentials when expressed with WT channels. In addition, two new patients with previously reported gain-of-function variants p.(N536H) and p.(N995S) are found to show epilepsy and paroxysmal dyskinesia as reported previously, but also exhibit additional symptoms of cognitive impairment, and dysmorphic features. Furthermore, variants p.(A314T) and p.(N536H) reduced total and membrane levels of BK proteins.
CONCLUSION
Our findings identified two new loss-of-function mutations of KCNMA1 associated with Liang-Wang syndrome, expanded the spectrum of clinical features associated with gain-of-function KCNMA1 variants, and emphasized the overlapping features shared by gain-of-function and loss-of-function mutations
Qu qiu bai yu cui
No full textQu qiu bai duan zan yi sheng zhong cong shi ge ming shi jian huo dong, ye jin xing da liang de li lun yan jiu he xuan chuan, wen xue chuang zuo he ping lun, ben shu shi cong ta zhu zuo he yi wen zhong ze qu jing cu
Song Yuan tong jian: yi bai wu shi qi juan. v.1
No full text薛應旂編集 ; 王道行, 朱袗校正.綫裝, 6函.框20.2x14.4公分, 10行20字, 小字雙行同, 白口, 單黑魚尾, 四周單邊, 版心中鐫題名及卷次, 下記刻工.刻書年據序.卷一卷端下印有"庚申七月二十三日點□ 小清涼山房識"鈐有"襃賞", "松代文庫", "無事讀書有客飲酒", "李彬之印", "懷宣", "李彬字曰懷宣"等印.Xian zhuang, 6 han.Kuang 20.2 x 14.4 gong fen, 10 hang 20 zi, xiao zi shuang hang tong, bai kou, dan hei yu wei, si zhou dan bian, ban xin zhong juan ti ming ji juan ci, xia ji ke gong.Ke shu nian ju xu.Juan yi juan duan xia yin you "Geng shen qi yue er shi san ri dian [...] Xiao qing liang shan fang shi"Xue Yingqi bian ji ; Wang Daoxing, Zhu Zhen jiao zheng.Qian you "Bao shang", "Song dai wen ku", "Wu shi du shu you ke yin jiu", "Li bin zhi yin", "Huai xuan", "Li bin zi yue huai xuan" deng yin
- …
