1,720,964 research outputs found
Manganese‐Catalyzed Carbonylative Annulations for Redox‐Neutral Late‐Stage Diversification
No full textAbstract An inexpensive, nontoxic manganese catalyst enabled unprecedented redox‐neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious‐metal catalysts. The outstanding versatility of the manganese catalysis manifold was reflected by ample substrate scope, setting the stage for effective late‐stage manipulations under racemization‐free conditions of a wealth of marketed drugs and natural products, including alkaloids, amino acids, steroids, and carbohydrates.Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659Alexander von Humboldt-Stiftung https://doi.org/10.13039/10000515
Ruthenium(IV) Intermediates in C−H Activation/Annulation by Weak O ‐Coordination
No full textAbstract Ruthenium(IV) complexes were identified as key intermediates of C−H/O−H activations by weak O ‐coordination. Thus, the annulations of sulfoxonium ylides by benzoic acids provided expedient access to diversely‐decorated isocoumarins with ample scope. Detailed experimental and computational studies provided strong support for a facile BIES‐C−H activation, along with cyclometalated ruthenium(IV) intermediates within a versatile ruthenium(II/IV) catalysis regime (BIES=base‐assisted internal electrophilic substitution).Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659Alexander von Humboldt-Stiftung https://doi.org/10.13039/100005156China Sponsorship Council https://doi.org/10.13039/50110000286
Continuous Visible‐Light Photoflow Approach for a Manganese‐Catalyzed (Het)Arene C−H Arylation
No full textCatalyst‐Guided C=Het Hydroarylations by Manganese‐Catalyzed Additive‐Free C−H Activation
No full textExpedient hydroarylations of C=Het bonds (Het = heteroatom) were accomplished by user-friendly organometallic C-H activation in a positional-selective manner. The broadly applicable C-H functionalization platform enabled the step-economical transformation of aldehydes, ketones, and imines under additive-free reaction conditions. In contrast to palladium, rhodium, ruthenium, rhenium, iridium, nickel, and cobalt catalysis, solely manganese(I) complexes outcompeted the innate substrate control, clearly highlighting the unique power of manganese(I) C-H activation catalysis
‐Coordination
No full textAbstract Ruthenium(IV) complexes were identified as key intermediates of C−H/O−H activations by weak O ‐coordination. Thus, the annulations of sulfoxonium ylides by benzoic acids provided expedient access to diversely‐decorated isocoumarins with ample scope. Detailed experimental and computational studies provided strong support for a facile BIES‐C−H activation, along with cyclometalated ruthenium(IV) intermediates within a versatile ruthenium(II/IV) catalysis regime (BIES=base‐assisted internal electrophilic substitution).Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659Alexander von Humboldt-Stiftung https://doi.org/10.13039/100005156China Sponsorship Council https://doi.org/10.13039/50110000286
Scalable reductive deuteration of (Hetero)Aryl chlorides with D2O
No full textNational Natural Science Foundation of China https://doi.org/10.13039/501100001809Taishan Scholar Foundation of Shandong Province https://doi.org/10.13039/10001262
Methylenecyclopropane Annulation by Manganese(I)-Catalyzed Stereoselective C−H/C−C Activation
No full textRegioselective B(3,4)–H arylation of o -carboranes by weak amide coordination at room temperature
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