102,551 research outputs found
Suppression of cell cycle progression by Jun dimerization protein (JDP2) involves down-regulation of cyclin A2
No full textWe report here a novel role for Jun dimerization protein-2 (JDP2) as a regulator of the progression of normal cells through the cell cycle. To determine the role of JDP2 in vivo, we generated Jdp2 knock-out (Jdp2KO) mice by targeting exon 1 to disrupt the site of initiation of transcription. The healing of wounded skin of Jdp2KO mice proceeded more rapidly than that of control mice and more proliferating cells were found at wound margins. Fibroblasts derived from embryos of Jdp2KO mice proliferated more rapidly and formed more colonies than wild-type fibroblasts. JDP2 was recruited to the promoter of the gene for cyclin A2 (ccna2) at a previously unidentified AP-1 site. Cells lacking Jdp2 had elevated levels of cyclin A2 mRNA. Moreover, reintroduction of JDP2 resulted in repression of transcription of ccna2 and of cell cycle progression. Thus, transcription of the gene for cyclin A2 appears to be a direct target of JDP2 in the suppression of cell proliferation
Separation of Phytosterol and Synthesized VE Succinate from Rapeseed Oil Deodorizer Distillate
No full textRosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is a paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 7 (2005): Separation of Phytosterol and Synthesized VE Succinate from Rapeseed Oil Deodorizer Distillate by Pan Li-jun, Shao Ping, Jiang Shao-ton
Limits of predictability for large-scale urban vehicular mobility
No full textKey challenges in vehicular transportation and communication systems are understanding vehicular mobility and utilizing mobility prediction, which are vital for both solving the congestion problem and helping to build efficient vehicular communication networking. Most of the existing works mainly focus on designing algorithms for mobility prediction and exploring utilization of these algorithms. However, the crucial questions of how much the mobility is predictable and how the mobility predictability can be used to enhance the system performance are still the open and unsolved problems. In this paper, we consider the fundamental problem of the predictability limits of vehicular mobility. By using two large-scale urban city vehicular traces, we propose an intuitive but effective model of areas transition to describe the vehicular mobility among the areas divided by the city intersections. Based on this model, we examine the predictability limits of large-scale urban vehicular networks and obtain the maximal predictability based on the methodology of entropy theory. Our study finds that about 78%–99% of the location and above 70% of the staying time, respectively, are predicable. Our findings thus reveal that there is strong regularity in the daily vehicular mobility, which can be exploited in practical prediction algorithm design
PAN-WEN HSUEH & YAN-HUEI LI (2014) New species and new records of eunicids (Polychaeta Eunicidae) from Taiwan. Zootaxa, 3802(2): 151-172.
No full textHsueh, Pan-Wen, Li, Yan-Huei (2014): PAN-WEN HSUEH & YAN-HUEI LI (2014) New species and new records of eunicids (Polychaeta Eunicidae) from Taiwan. Zootaxa, 3802(2): 151-172. Zootaxa 3821 (5): 600-600, DOI: http://dx.doi.org/10.11646/zootaxa.3821.5.
INI881502 Supplemental Material - Supplemental material for Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway
No full textSupplemental material, INI881502 Supplemental Material for Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway by Lingling Jia, Hao Chen, Jun Yang, Xin Fang, Wenying Niu, Ming Zhang, Jiahong Li, Xiaohua Pan, Zhengnan Ren, Jia Sun and Li-Long Pan in Innate Immunity</p
kelwyres/KpSC-pan-metabolic-model: KpSC-pan-v2.0
No full text<p>Updated KpSC pan metabolic model including:</p>
<ul>
<li>1138 additional genes as compared to KpSC pan v1</li>
<li>1231 additional reactions, including 57 additional exchange reactions (enable substrate usage simulations) as compared to KpSC pan v1</li>
<li>updated biomass objective function to remove requirement for strain-specific capsule sugars</li>
</ul>
<p>For full details and information about phenotypic validation, see https://doi.org/10.1101/2023.12.20.572682.</p>
sj-docx-1-taj-10.1177_2040622321995685 – Supplemental material for Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the HGF/PTEN/Wnt/β-catenin axis
No full textSupplemental material, sj-docx-1-taj-10.1177_2040622321995685 for Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the HGF/PTEN/Wnt/β-catenin axis by Jun Zhang, Guoliang Jia, Pan Xue and Zhengwei Li in Therapeutic Advances in Chronic Disease</p
sj-eps-2-taj-10.1177_2040622321995685 – Supplemental material for Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the HGF/PTEN/Wnt/β-catenin axis
No full textSupplemental material, sj-eps-2-taj-10.1177_2040622321995685 for Melatonin restores osteoporosis-impaired osteogenic potential of bone marrow mesenchymal stem cells and alleviates bone loss through the HGF/PTEN/Wnt/β-catenin axis by Jun Zhang, Guoliang Jia, Pan Xue and Zhengwei Li in Therapeutic Advances in Chronic Disease</p
Complete mitogenome and phylogenetic significance of Metoecus javanus (Pic, 1913) (Coleoptera: Ripiphoridae) from Southwest China, with notes on morphological traits of adult and immature stages
No full textLi, Jun, Zhou, Zheng, Mao, Chuyang, Pan, Zhao, Yao, Yuhao, He, Jinwu, Lin, Yan, Dong, Zhiwei, Liu, Guichun, Zhao, Ruoping, Wang, Wen, Li, Xueyan (2022): Complete mitogenome and phylogenetic significance of Metoecus javanus (Pic, 1913) (Coleoptera: Ripiphoridae) from Southwest China, with notes on morphological traits of adult and immature stages. Zootaxa 5205 (3): 231-248, DOI: https://doi.org/10.11646/zootaxa.5205.3.
Supplemental_Figures - Progesterone-Induced miR-145/miR-143 Inhibits the Proliferation of Endometrial Epithelial Cells
No full textSupplemental_Figures for Progesterone-Induced miR-145/miR-143 Inhibits the Proliferation of Endometrial Epithelial Cells by Dong-zhi Yuan, Yi Lei, Dan Zhao, Jun-li Pan, You-bo Zhao, Li Nie, Min Liu, Yun Long, Jin-hu Zhang, and Li-min Yue in Reproductive Sciences</p
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