55,317 research outputs found
The computer sucks!!!
No full textThe Computer Sucks!!! by Ho Li Ting, is an animated comedy film about a gamer who finds himself trapped within his own computer.
A light-hearted and punny parody of the computer and the Internet, this film follows his many adventures including exploring the Desktop, an encounter with Mozilla Firefox and his escape. Viewers will never see the computer in the same light again.Bachelor of Fine Art
sj-docx-1-pec-10.1177_03010066221135472 - Supplemental material for You are how you speak: The roles of vocal pitch and semantic cues in shaping social perceptions
No full textSupplemental material, sj-docx-1-pec-10.1177_03010066221135472 for You are how you speak: The roles of vocal pitch and semantic cues in shaping social perceptions by Hannah Xiaohan Wu, Yuanhua Li, Boby Ho-Hong Ching and Tiffany Ting Chen in Perception</p
Conditional Modeling-Based Approach for Two Dimensional Dose Finding in Phase I Trials : An Alternative Approach of Thall et al.’s Method
No full text 第一期臨床試驗的主要目的在於尋找藥物安全的劑量，以備後續二、三期試驗參考。單劑量的安全劑量尋找，於統計上可看成劑量－毒性的二維反應曲線建構，當劑量推展到二劑量時，統計問題成為雙劑量－毒性之三維曲面建構，較建構二維曲面問題複雜許多，統計難度包括在雙劑量的交互作用描述及整體模式的參數估計。本研究目的在以雙劑量－毒性反應模式為基礎下，以條件模式方法將雙劑量－毒性反應轉化為二個條件單劑量－毒性反應模式，這種作法的好處在於條件模式仍可反映雙劑量之交互作用，且可以避免直接處理雙劑量模式的複雜性。The primary purpose of a phase I clinical trial is to determine the safety dose of a new drug for later trials use. Many statistical methods have been proposed for the determination of dose for a single drug. In statistical sense it can be regarded as a two-dimensional dose-toxicity curve fitting problem. In many trials, however, investigators are more interested in finding the doses for multiple agents. When there are multiple agents, statistical problem becomes more complicated due to the interaction among agents, and the monotonicity between toxicity and dose can no longer be assumed as that in the case of a single agent. For a two-agent trial, we have to deal with the three-dimensional curve fitting problem. A previous method used a joint-probability regression model to undergo the model-setting for toxicity response curve with two agents. Hence, we modify this method by dividing the model into two conditional models. Each conditional model describes the toxicity reaction of an agent conditional on the other agent. The advantage of our method is to avoid complexity in estimation but still retain the capability of the original method in coping with interaction between two agents.第一章 緒論 1
1.1 前言 1
1.2 研究動機 10
第二章 文獻回顧 12
2.1 利用所有劑量組合之一個子集合尋求MTD 13
2.2 固定其中一藥物劑量的條件式做法 16
2.3 利用等效劑量之關係的方法 17
2.4 利用六個參數的雙維度模式估計MTD 20
第三章 條件模式為基礎的二藥物劑量估計方法 22
3.1 劑量－毒性反應機率模式 22
3.2 資料結構與模型架構 27
3.3 建構與估計模式 31
第四章 討論 46
Reference 51
附錄一 藥物的不良反應（Adverse drug reaction） 53
附錄二 劑量增量計算方法（Modified Fibonacci Scheme） 54
附錄三 交叉抗藥性（Cross-resistance） 55
附錄四 概似比檢定（Likelihood-ratio test） 55
附錄五 牛頓法（Newton-Raphson Method） 57
附錄六 逐步檢驗虛無擬說之細節 59
1. 對於藥物毒性效果的討論 59
2. 未加入藥物時的劑量反應是否相同之討論 84
圖2.1降維度之方法 14
圖2.2九個劑量階段 15
表2.1劑量增加的概要 17
圖2.3耐受劑量與兩藥物合併之毒性反應。 19
圖3.1模式中參數的意義 26
圖3.2參數精簡之流程圖 33
圖4.1等毒性反應線可能之輪廓 4
sj-doc-1-npx-10.1177_1934578X231206228 - Supplemental material for Curcumin Protects Pheochromocytoma Cells Against Hydrogen Peroxide-Induced Oxidative Stress
No full textSupplemental material, sj-doc-1-npx-10.1177_1934578X231206228 for Curcumin Protects Pheochromocytoma Cells Against Hydrogen Peroxide-Induced Oxidative Stress by Xiaoting Sun, Lu Chen, Lingli Lin, Kuo-Ting Ho, Shi-Ying Huang, Jian Li, Jingwen Liu, Zhengxiao Zhang and Guiling Li in Natural Product Communications</p
The 1961 Kampong Bukit Ho Swee fire and the making of modern Singapore
No full textBy 1970, Singapore’s urban landscape was dominated by high-rise blocks of planned public housing built by the People’s Action Party government, signifying the establishment of a high modernist nation-state. A decade earlier, the margins of the City had been dominated by kampongs, home to semi-autonomous communities of low-income Chinese families which freely built, and rebuilt, unauthorised wooden houses. This change was not merely one of housing but belied a more fundamental realignment of state-society relations in the 1960s. Relocated in Housing and Development Board flats, urban kampong families were progressively integrated into the social fabric of the emergent nation-state. This study examines the pivotal role of an event, the great Kampong Bukit Ho Swee fire of 1961, in bringing about this transformation. The redevelopment of the fire site in the aftermath of the calamity brought to completion the British colonial regime’s ‘emergency’ programmes of resettling urban kampong dwellers in planned accommodation, in particular, of building emergency public housing on the sites of major fires in the 1950s. The PAP’s far greater political resolve, and the timing of and state of emergency occasioned by the scale of the 1961 disaster, enabled the government to rehouse the Bukit Ho Swee fire victims in emergency housing in record time. This in turn provided the HDB with a strategic platform for clearing other kampongs and for transforming their residents into model citizens of the nation-state. The 1961 fire’s symbolic usefulness extended into the 1980s and beyond, in sanctioning the PAP’s new housing redevelopment schemes. The official account of the inferno has also become politically useful for the government of today for disciplining a new generation of Singaporeans against taking the nation’s progress for granted. Against these exalted claims of the fire’s role in the Singapore Story, this study also examines the degree of actual change and continuity in the social and economic lives of the people of Bukit Ho Swee after the inferno. In some crucial ways, the residents continued to occupy a marginal place in society while pondering, too, over the unresolved question of the cause of the fire. These continuities of everyday life reflect the ambivalence with which the citizenry regarded the high modernist state in contemporary Singapore
The Chinese romanticism : The life and thoughts of Li Ho /
No full text2. The life and thoughts of Li Ho
Li, Chi Hung (Son) Ho Hin (Father), [No Service Number]
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/399386Surname: LI. Given Name(s) or Initials: CHI HUNG (SON) HO HIN (FATHER). Military Service Number or Last Known Location: [No Registration Number]. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 26641.217155
Item: [2016.0049.31679] "Li, Chi Hung (Son) Ho Hin (Father), [No Service Number]
Elderly, vertical village: a comprehensive community for elderly.
No full textCheung Ho Ting Kenniss."Architecture Department, Chinese University of Hong Kong, Master of Architecture Programme 2005-2006, design report."thesis statement --- p.p1-2background studies --- p.p3-6research - ideas formation --- p.p7-10research - tangible studies --- p.p11-14research - conclusion (i) --- p.p15-16research - intangible studies --- p.p17-19research - ifield trip --- p.p20-21research - conclusion (ii) --- p.p22-23deisgn concept --- p.p24-25site --- p.p26-31desighn process --- p.p32-50final design --- p.p51-5
Synthesis and Characterization of Li(2)MgGeO(4):Ho(3+)
No full textIn this work, the synthesis and characterization of Li(2)MgGeO(4):Ho(3+) ceramics were reported. The X-ray diffraction measurements revealed that the studied ceramics belong to the monoclinic Li(2)MgGeO(4). Luminescence properties were analyzed in the visible spectral range. Green and red emission bands correspondent to the (5)F(4),(5)S(2)→(5)I(8) and (5)F(5)→(5)I(8) transitions of Ho(3+) were observed, and their intensities were significantly dependent on activator concentration. Luminescence spectra were also measured under direct excitation of holmium ions or ceramic matrix. Holmium ions were inserted in crystal lattice Li(2)MgGeO(4), giving broad blue emission and characteristic 4f-4f luminescent transitions of rare earths under the selective excitation of the ceramic matrix. The presence of the energy transfer process between the host lattice and Ho(3+) ions was suggested
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