10,871 research outputs found
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
No full textMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
sj-pdf-1-ang-10.1177_00033197221091315 – Supplemental Material for Relation Between New York Heart Association Functional Class and Remnant Cholesterol, and Non-high Density Lipoprotein Cholesterol in Coronary Heart Disease Patients With Type 2 Diabetes Mellitus
No full textSupplemental Material, sj-pdf-1-ang-10.1177_00033197221091315 for Relation Between New York Heart Association Functional Class and Remnant Cholesterol, and Non-high Density Lipoprotein Cholesterol in Coronary Heart Disease Patients With Type 2 Diabetes Mellitus by Qi Cheng, Zhu Li, Xu Wang, Shuo Wang, Yijia Liu, Mengnan Huang, Yue Li, Xiaoxue Xue, Huaien Bu, Rongrong Yang, Yilan Xu, Lin Li, Shan Gao, Yanchao Zheng and Chunquan Yu in Angiology</p
sj-pdf-1-ang-10.1177_00033197211059693 – Supplemental Material for Dose-Response Association Between Bilirubin and Cardiovascular Disease: A Systematic Review and Meta-analysis
No full textSupplemental Material, sj-pdf-1-ang-10.1177_00033197211059693 for Dose-Response Association Between Bilirubin and Cardiovascular Disease: A Systematic Review and Meta-analysis by Lei Zuo, Jun Huang, Hongyue Zhang, Bing Huang, Xiaoyi Wu, Li Chen, Sujian Xia, Xiaomei Dong and Guang Hao in Angiology</p
sj-pdf-1-ang-10.1177_00033197221105745 – Supplemental Material for Non-Invasive Liver Fibrosis Scores Are Associated With Contrast-Associated Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention
No full textSupplemental Material, sj-pdf-1-ang-10.1177_00033197221105745 for Non-Invasive Liver Fibrosis Scores Are Associated With Contrast-Associated Acute Kidney Injury in Patients Undergoing Elective Percutaneous Coronary Intervention by Hao-Ming He, Chen He, Zhe-Bin You, Si-Cheng Zhang, Xue-Qin Lin, Man-Qing Luo, Mao-Qing Lin, Li-Wei Zhang, Kai-Yang Lin and Yan-Song Guo in Angiology</p
sj-pdf-1-ang-10.1177_00033197221087778 – Supplemental Material for High-Risk Culprit Plaque Predicts Cardiovascular Outcomes Independently of Plaque Rupture in ST-Segment Elevation Myocardial Infarction: Insight From Optical Coherence Tomography
No full textSupplemental Material, sj-pdf-1-ang-10.1177_00033197221087778 for High-Risk Culprit Plaque Predicts Cardiovascular Outcomes Independently of Plaque Rupture in ST-Segment Elevation Myocardial Infarction: Insight From Optical Coherence Tomography by Ying Wang, Xiaoxiao Zhao, Peng Zhou, Chen Liu, Zhiyong Liao, Xiaoqing Wang, Shaodi Yan, Zhaoxue Sheng, Jiannan Li, Jinying Zhou, Runzhen Chen, Yi Chen, Li Song, Hanjun Zhao and Hongbing Yan in Angiology</p
Voices from the diaspora: changing hierarchies and dynamics of Chinese multilingualism
No full textThe so-called Chinese diasporas, i.e. Chinese communities outside Greater China (China, Hong Kong, Macau, and Taiwan), have traditionally been dialect dominant; that is, the vast majority of Chinese immigrants are speakers of (especially Southern) dialects. Cantonese and Hokkien are two of the most prominent dialects. With globalization and the rise of China as a world politico-economic power, the national, standardized variety, Putonghua, is gaining particular prestige amongst the Chinese diasporas. For example, all the Cantonese schools for British Chinese children in the UK now also teach Putonghua, but none of the Putonghua schools teach Cantonese. Using ethnographic interviews with and participant observation of Chinese people of different generations in various diasporic communities, this paper examines the changing hierarchies of varieties of Chinese, the implications of such changes for the education and identity development of the young, and the constitution of a (speech) community in the post-modern era. It focuses on language attitude and linguistic practices (including literacy practices). It also investigates the tensions between the competing ideologies and discourses on national and ethnic identities, nationalism, community relations and cultural values
Data for: iTRAQ-based quantitative proteomic analysis provides insights into strong broodiness in Muscovy duck (Cairina moschata) combined with metabolomics analysis
No full textRaw data on proteomics and metabolomics sequencing
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