1,725,995 research outputs found
DataSheet_1_Qi-Li-Qiang-Xin Alleviates Isoproterenol-Induced Myocardial Injury by Inhibiting Excessive Autophagy via Activating AKT/mTOR Pathway.docx
No full textBackground: Apoptosis and autophagy are two important patterns of cell death in the process of heart failure. Qi-Li-Qiang-Xin (QLQX), a traditional Chinese medicine, has been frequently used in the treatment of chronic heart failure (CHF) in China. However, the potential effect of QLQX on autophagy has not been reported. In this study, we aimed to investigate whether QLQX alleviated isoproterenol (ISO)-induced myocardial injury through regulating autophagy.Methods: The rapid identification of chemical ingredients of QLQX was performed by UPLC-Q-TOF-MS, and the contents of major constituents in QLQX were also measured by UPLC-Q-TOF-MS. ISO was used to induce myocardial injury in H9c2 cardiomyocytes and SD rats. In vivo, cardiac function was evaluated by echocardiography and cardiac structure was observed by HE and Masson staining. Expressions of Bcl-2, Bax, LC3, P62, AKT, p-AKT, mTOR, and p-mTOR were detected by western blotting. In vitro, H9c2 cells were pretreated with QLQX for 3 h before ISO (80 µM, 48h) addressed. Cell viability, LDH and CK-MB release, apoptosis ratio, and the level of autophagy were measured. Western blotting was also performed to detected related protein expressions.Result:In vivo, treatment by QLQX significantly improved cardiac function and alleviated ISO-induced myocardial structural damage. In addition, QLQX markedly decreased apoptosis and inhibited autophagic activity, accompanied by activating the AKT/mTOR pathway. In vitro, the increased cell apoptosis induced by ISO was paralleling with the gradually increasing level of autophagy. Furthermore, 3-MA, an autophagic inhibitor, could block ISO-induced autophagy in H9c2 cells. Our results suggested that both QLQX and 3-MA treatment could decrease cell death induced by ISO, implying that QLQX protected against ISO-induced myocardial injury possibly by inhibiting excessive autophagy-mediated cell death. In addition, blockage of AKT signaling by an AKT inhibitor, capivasertib, could reduce the effect of QLQX on inhibiting ISO-induced apoptosis and autophagy-mediated cell death.Conclusion: QLQX could alleviate ISO-induced myocardial injury by inhibiting apoptosis and excessive autophagy-mediated cell death via activating the AKT/mTOR pathway.</p
Impact of scour on lateral resistance of wind turbine monopiles: An experimental study
Get PDFThe majority of offshore wind structures are supported on large-diameter, rigid monopile foundations. These piles may be subjected to scour due to the waves and currents that causes a loss of soil support and consequently decreases the pile capacity and system stiffness. The results of numerical models suggest that the shape of the scour hole affects the magnitude of pile capacity loss; however, there is a dearth of experimental test data that quantify this effect. This paper presents a series of centrifuge model tests on an instrumented model pile that investigates the effects of scour-hole geometry on the response of a laterally loaded pile embedded in sand. The pile instrumentation allowed load–displacement and p–y (soil reaction – displacement) curves to be derived. Three scour geometries (global, local wide, and local narrow) and three scour depths (1D, 1.5D, and 2D; where D is pile diameter) were modelled. For all three scour types, pile moment capacity decreased almost linearly with increase of scour depth. Simple empirical relations were proposed to evaluate the detrimental influence of scour on the pile moment capacity. A new method has been developed to allow designers to quantify the effect of scour-hole shape and severity of scour on the pile response.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Geo-engineerin
Lateral response of rigid monopiles subjected to cyclic loading: Centrifuge modelling
No full textIn this study, a total number of 20 centrifuge tests were carried out to investigate monopile behaviour under lateral cyclic loading. The instrumented model pile simulates an offshore wind turbine foundation with an embedment ratio of 5 installed in sand layers with two relative densities of 80% and 50%. The influence of the directional characteristic and amplitude of cyclic load on pile lateral behaviour was studied. The data analysis focused on the influence of cyclic load on the accumulation of lateral displacement and evolution of secant stiffness of the foundation system. The most damaging cyclic load type (which can cause the most accumulated pile displacement) is identified as two-way loading, and it was observed that cyclic load always increases the pile secant stiffness. A new model for the prediction of evolution of accumulated displacement and change in secant stiffness has been formulated. An example of the procedure developed is presented for a typical field monopile subjected to cyclic loading. Lastly, the performance of the new model is demonstrated and predicted results are compared with field test data. Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Geo-engineerin
Galactic Rotation Curves in Conformal Scalar-Tensor Gravity
No full textWe show quantitatively that an exact solution of conformal scalar-tensor gravity can explain very well the galactic rotation curves for a sample of 104 galaxies without the need for dark matter or other exotic modification of gravity. The metric is an overall rescaling of the Schwarzschild-de Sitter space-time as required by Weyl conformal invariance, which has to be spontaneously broken, and the velocity of the stars depends only on two fixed universal parameters. Using the Monte Carlo Markov Chain (MCMC) method, we make a fit of the observational rotation curves in order to get the mass-to-light ratio for each galaxy. Finally, we analytically compare our model with the modified Newtonian dynamics (MOND) and the metric skew tensor gravity (MSTG) showing that the three theories have a very different behavior at very large distances
The genus Polemistus de Saussure in China with descriptions of four new species (Hymenoptera: Crabronidae)
No full textMa, Li, Li, Qiang (2020): The genus Polemistus de Saussure in China with descriptions of four new species (Hymenoptera: Crabronidae). Zootaxa 4852 (4): 475-484, DOI: 10.11646/zootaxa.4852.4.
Two new species of the genus Pison Jurine (Hymenoptera: Crabronidae) from China, with a key to the Chinese species
No full textLi, Tingjing, Li, Qiang (2011): Two new species of the genus Pison Jurine (Hymenoptera: Crabronidae) from China, with a key to the Chinese species. Zootaxa 3007: 61-68, DOI: 10.5281/zenodo.20805
FIGURES 1–8. Pison irramulus n in Two new species of the genus Pison Jurine (Hymenoptera: Crabronidae) from China, with a key to the Chinese species
No full textFIGURES 1–8. Pison irramulus n. sp. 1. Female, habitus of holotype, dorsal view. 2. Male, habitus of one paratype, dorsal view. 3.Published as part of Li, Tingjing & Li, Qiang, 2011, Two new species of the genus Pison Jurine (Hymenoptera: Crabronidae) from China, with a key to the Chinese species, pp. 61-68 in Zootaxa 3007 on page 63, DOI: 10.5281/zenodo.20805
Passaloecus monilicornis subsp. taiwanus Tsuneki 1967
No full text8. Passaloecus monilicornis taiwanus Tsuneki, 1967 Distribution: China (Taiwan: Chiayi Prefecture: Mt. Ali).Published as part of Ma, Li & Li, Qiang, 2012, Key to the Oriental species of Passaloecus Shuckard (Hymenoptera: Crabronidae), with descriptions of four new species from China, pp. 41-50 in Zootaxa 3329 (1) on page 49, DOI: 10.11646/zootaxa.3329.1.4, http://zenodo.org/record/525161
A new species of genus Prosopigastra A. Costa (Hymenoptera: Crabronidae: Crabroninae) from China, with a key to the Chinese species
No full textZhao, Liyuan, Li, Qiang, Ma, Li (2021): A new species of genus Prosopigastra A. Costa (Hymenoptera: Crabronidae: Crabroninae) from China, with a key to the Chinese species. Zootaxa 5072 (2): 157-164, DOI: https://doi.org/10.11646/zootaxa.5072.2.
A rare genus Odontopsen Tsuneki in China (Hymenoptera: Apoidea: Crabronidae), with description of a new species
No full textMa, Li, Li, Qiang, Chen, Xue-Xin (2010): A rare genus Odontopsen Tsuneki in China (Hymenoptera: Apoidea: Crabronidae), with description of a new species. Zootaxa 2359: 58-60, DOI: 10.5281/zenodo.19361
- …
