527 research outputs found
Xiao er yao zheng zhen jue: [3 juan]. v.46
No full text錢乙撰 ; [李錫齡輯]宏道書院藏板.Date from preface.Qian Yi zhuan ; [Li Xiling ji]Hong dao shu yuan cang ban
Wei sheng bao jian: [24 juan, bu yi]. v.48
No full text羅天益撰 ; [李錫齡輯]宏道書院藏板.Date from preface.Luo Tianyi zhuan ; [Li Xiling ji]Hong dao shu yuan cang ban
Xing lu jie
No full text王崇慶撰 ; [李錫齡輯]宏道書院藏板.Date from preface.Wang Chongqing zhuan ; [Li Xiling ji]Hong dao shu yuan cang ban
Notch Signaling: Mechanistic And Functional Studies In Intestinal Stem Cells And Colorectal Cancer Cells
No full text: The study of stem cell regulation in intestinal and colonic tissues is an area of significant focus within the scientific community, providing mechanistic insight into biological process and offering translational clinical potential. In this thesis we address the contribution of NOTCH signaling in maintaining the stem cell niche by modulating the mode of stem cell division and receptor-ligand interactions for cell-cell communication. Furthermore, we examine NOTCHmediated spatiotemporal recovery of the intestinal stem cell (ISC) niche following single cell ablation. Finally, we demonstrate that elevated NOTCH signaling exists under conditions of physiological stress and in colon cancer initiating cells (CCICs), promoting tumorigenic potential of the intestinal epithelium. Overall, our research highlights the underlying complexities of NOTCH signaling as an essential pathway to maintain intestinal homeostasis and may inspire development of novel CRC therapeutic strategies. Research efforts and findings during my graduate study have been consolidated into the following peer-reviewed publications, of which the four first co-author manuscripts are described in detail in this dissertation. 1. Srinivasan, Tara; Walters, Jewell; Bu, Pengcheng; Than, Elaine B.; Tung, Kuei-Ling; Chen, Kai-Yuan; Panarelli, Nicole; Milsom, Jeff; Augenlicht, Leonard; Lipkin, Steven M; Shen, Xiling. "NOTCH Signaling Regulates Asymmetric Division of Fast- and Slow-Cycling Colon Cancer Initiating Cells." Cancer Research, 2016. (in press) 2. Srinivasan, Tara; Than, Elaine B.; Bu, Pengcheng; Tung, Kuei-Ling; Chen, Kai-Yuan; Augenlicht, Leonard; Lipkin, Steven M.; Shen, Xiling. "NOTCH Signaling Regulates Fast- and Slow-Cycling Intestinal Stem Cells." Scientific Reports, 2016. (in press) 3. Chen, Kai-Yuan*; Srinivasan, Tara*; Choi, Jiahn*; Bu, Pengcheng; Tung, Kuei-Ling; Nishimura, Nozomi; Shen, Xiling. "Dynamic regulation of intestinal stem cell niche recovery in real-time." Cell Systems, 2015. (in review) 4. Murthy, Preetish KL*; Srinivasan, Tara*; Bochter, Skye; Bu, Pengcheng; Cole, Susan; Shen, Xiling. "FRINGE-dependent modification of NOTCH Ligands in Intestinal Stem Cells." 2016. (in preparation) 5. Rothschild, Daniel; Srinivasan, Tara; Aponte-Santiago, Linette; Shen, Xiling; Irving, Allen. "The Ex Vivo Culture and Pattern Recognition Receptor Stimulation of Mouse Intestinal Organoids." JoVE, 2015. (in press) 6. Bu, Pengcheng*; Wang, Lihua*; Chen, Kai-Yuan; Srinivasan, Tara; Lakshminarasimha, Preetish; Tung, Kuei-Ling; Varanko, Anastasia; Ai, Yiwei; Lipkin, Steven; Shen, Xiling. "miR34a and Numb synergize for asymmetric cell fate determination." Cell Stem Cell, 2016 Feb 4;18(2):189-202. 7. Crespo, Miguel; Tsai, Su-Yi; Srinivasan, Tara; Pipalia, Nina; Maxfield, Nina; Lipkin, Steven M; Evans, Todd; Chen, Shuibing. "Colonic Organoids Derived from Human Pluripotent Stem Cells for Modeling Colorectal Cancer and Drug Testing." Nature Medicine, 2015. (in review) 8. Wang, Lihua*; Bu, Pengcheng*; Ai, Yiwel; Srinivasan, Tara; Lipkin, Steven M; Shen, Xiling. "A Long Non-Coding RNA Targets MicroRNA miR-34a to Regulate Colon Cancer Stem Cell Asymmetric Division." eLife, 2016. (in press
Kang zhan: du mu xin ju xuan.
No full text在烽火中 / 沈西苓 -- 重逢 / 丁玲 -- 爭取最後勝利 / 塞克 -- 游擊隊的開始 / 張克 -- 我們打沖鋒 / 尤兢 -- 漢奸末路 / 姚時曉 -- 榮譽大隊 / 趙明, 呂復 -- 夜之歌 / 凌鶴 -- 我們放開恩怨 / 石靈 -- 舞女淚 / 集體創作.[沈西苓 ... [et al.]著] ; 戰時劇社編.[Shen Xiling ... [et al.] zhu] ; Zhan shi ju she bian.Zai feng huo zhong / Shen Xiling -- Chong feng / Ding Ling -- Zheng qu zui hou sheng li / Sai Ke -- You ji dui de kai shi / Zhang Ke -- Wo men da chong feng / You Jing -- Han jian mo lu / Yao Shixiao -- Rong yu da dui / Zhao Ming, Lü Fu -- Yan zhi ge / Ling He -- Mo men fang kai en yuan / Shi Ling -- Wu nü lei / Ji ti chuang zuo
sj-docx-2-jva-10.1177_11297298211052528 – Supplemental material for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial
No full textSupplemental material, sj-docx-2-jva-10.1177_11297298211052528 for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial by Chunli Huang, Zhenming Wu, Weihua Huang, Xinghong Zhang, Xiling Lin, Jielin Luo, Lihua Li and Jia Li in The Journal of Vascular Access</p
sj-docx-1-jva-10.1177_11297298211052528 – Supplemental material for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial
No full textSupplemental material, sj-docx-1-jva-10.1177_11297298211052528 for Identifying the impact of the Zone Insertion MethodTM (ZIMTM): A randomized controlled trial by Chunli Huang, Zhenming Wu, Weihua Huang, Xinghong Zhang, Xiling Lin, Jielin Luo, Lihua Li and Jia Li in The Journal of Vascular Access</p
Pegohylemyia euryisurstyla Deng, Liu & Li 1995
No full texteuryisurstyla Deng, Liu & Li, 1995a: 375 (Pegohylemyia). Holotype male with labels: (1) handwritten on white label: “Xicen / 94.6.21”; (2) printed on red label: “ HOLOTYPE ”; (3) printed with handwritten inscriptions on white label: “ Pegohylemyia / euryisurstyla / Identifier: Anxiao Deng ”; (4) printed with handwritten inscriptions on red label: “ TYPE / Botanophila / euryisurstyla / (Deng, Liu et Li) ”. Preservation: pinned; genitalia dissected and mounted on slide pinned with the specimen. Missing parts: left mid leg, right wing. Additional notes: Holotype male collected by Ling Li at sonw mountain of Xiling, Dayi County, Sichuan Province; labels of Holotype pinned by Anxiao Deng, but the date of collection on the label (94.6.21) do not match with the date in the original publication (1994.6.4). Current name: Botanophila euryisurstyla (Deng, Liu & Li, 1995).Published as part of ZHANG, XUFENG & ZHU, WEIBING, 2014, The types of Anthomyiidae (Diptera) in the Shanghai Entomological Museum, Chinese Academy of Science, China, pp. 1-67 in Zootaxa 3756 (1) on page 21, DOI: 10.11646/zootaxa.3756.1.1, http://zenodo.org/record/503313
Acoustic Monitoring Dataset for Robotic Laser Directed Energy Deposition (LDED) of Maraging Steel C300
No full text<p>This dataset presents a set of acoustic signals captured during a single-bead wall experiment in robotic Laser Directed Energy Deposition (LDED) using Maraging Steel C300. The acoustic data was recorded using a high-fidelity Prepolarized microphone sensor (Xiris WeldMIC), capturing the intricate sound profiles associated with the LDED process at a sampling rate of 44,100 Hz.</p><p><strong>Laser Directed Energy Deposition:</strong></p><p>This dataset was generated with a robotic LDED process that consists of a six-axis industrial robot (KUKA KR90) coupled with a two-axis positioner, a laser head, and a coaxial powder-feeding nozzle.</p><p> </p><p><strong>Folder Structure:</strong></p><ul><li><strong>/sample-1</strong>: The main folder for the experiment sample.<ul><li><strong>/audio_files</strong>: Contains 4624 <strong>.wav</strong> audio files, each representing a 40 ms chunk of the LDED process sound.</li><li><strong>/annotations_1.csv</strong>: A CSV file providing annotations for the audio files, labeling each as "Defect-free", "Defective", or "Laser-off".</li></ul></li><li>audio_features.h5: extracted acoustic features in time-domain, frequency-domain, and time-frequency representations (MFCC features). Feature extraction was conducted using Python Essentia Library.</li></ul><p> </p><p><strong>File Naming Convention:</strong></p><ul><li>Audio files within the <strong>audio_files</strong> folder are named following the pattern <strong>sample_ExperimentID_SampleID.wav</strong>. Given that there's only one experiment and one sample, the naming will be consistent, for example, <strong>sample_1_1.wav</strong> for the first file.</li></ul><p><strong>Annotation Details:</strong></p><ul><li>The <strong>annotations_1.csv</strong> file contains detailed labels for each audio file, correlating to the conditions observed during the experiment, aiding in quick identification and analysis.</li></ul><p><strong>Experimental Parameters:</strong> The dataset reflects a controlled experiment setup with the following specifications:</p><ul><li>Geometry: Single bead wall structure</li><li>Dimensions: 90 mm * 42.5 mm</li><li>Number of layers: 50</li><li>Laser beam diameter: 2 mm</li><li>Layer thickness: 0.85 mm</li><li>Stand-off distance: 12 mm</li><li>Laser profile: Gaussian</li><li>Laser wavelength: 1064 nm</li></ul><p><strong>Process Parameters:</strong></p><ul><li>Laser power: 2.3 kW</li><li>Speed: 25 mm/s</li><li>Dwell time: 0 s</li><li>Powder flow rate: 12 g/min</li></ul><p>This dataset aims to facilitate the development and testing of acoustic-based defect detection models for real-time quality monitoring in LDED processes. It can also serve as a reference point for further research on sensor fusion, machine learning, and real-time monitoring of manufacturing processes.</p>
Labomimus niger Zhang & Li & Yin 2019, sp. nov.
No full textLabomimus niger sp. nov. (Figs. 16B, 18) Type material (1 ♂). Holotype: CHINA: ♂: ‘ China: Sichuan, Dayi County (大邑县), Xiling Xueshan (西岭雪山), 30°41′59′′N, 103°12′10′′E, mixed leaf litter, sifted, 2150 m, 29.VII.2015, Jiang, Peng, Tu, & Zhou leg.’ (SNUC). Diagnosis of male. Length approaching 3.50 mm; body black; antennomeres IX–X strongly modified, antennomere IX strongly expanded, obliquely connected with transverse antennomere X; short metaventral processes rounded apically; protrochanter with short, blunt ventral projection, profemur with large ventral spine, protibia with large, triangular apical spine; mesotrochanter with distinct ventral spine, mesotibia with tiny apical spine; aedeagus slightly asymmetric, with median lobe narrowing from middle toward apex. Description. Male (Fig. 16B). Length 3.46 mm. Body black. Head longer than wide, HL 0.72 mm, HW 0.65 mm; eyes prominent, each composed of about 45 facets. Antenna with scape about 2.3 times as long as wide, antennomeres II–VII more or less elongate, antennomere VIII small and transverse, antennomere IX (Fig. 18A) strongly expanded, antennomere X transverse, obliquely connected with IX. Pronotum (Fig. 18B) slightly longer than wide, PL 0.68 mm, PW 0.65 mm, sides strongly angulate at apical two-fifths. Elytra much broader than long, EL 0.90 mm, EW 1.23 mm. Metaventral processes (Fig. 18C) short, rounded at apex in lateral view. Protrochanter (Fig. 18D) with short, blunt ventral spine, profemur with large ventral spine at middle, protibia (Fig. 18E) with triangular spine at apex; mesotrochanter (Fig. 18F) with distinct ventral spine, mesofemur strongly expanded at middle, mesotibia (Fig. 18G) with tiny spine at apex; metacoxa, metatrochanter, and metafemur (Fig. 18H) simple. Abdomen broad at base and narrowed posteriorly, AL 1.16 mm, AW 1.23 mm; tergite IV longest, more than twice as long as tergite V; sternite IX as in Fig. 18I. Length of aedeagus (Fig. 18 J–L) 0.56 mm; median lobe asymmetric, narrowing apically; parameres short. Female. Unknown. Distribution. China: Sichuan. Etymology. The specific epithet refers to the black body color of the new species. Comparative notes. The new species is most similar to L. venustus (Yin & Li, 2012) from Yunnan in sharing similar forms of the antennal clubs and aedeagus. They can be separated by the mesotibia with a small apical spine (with large and long apical projection in L. venustus), and the dark body color of the new species.Published as part of Zhang, Yu-Qing, Li, Li-Zhen & Yin, Zi-Wei, 2019, Fifteen new species and a new country record of Labomimus Sharp from China, with a checklist of world species (Coleoptera: Staphylinidae: Pselaphinae), pp. 497-531 in Zootaxa 4554 (2) on pages 518-520, DOI: 10.11646/zootaxa.4554.2.7, http://zenodo.org/record/262389
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