657 research outputs found
AnicI ManlI Severini BoetI De consolatione philosophiæ libri qvinqve /
No full textDrukkersmerk, sierinitialenThere is a colophon on f. I7 verso that reads 'M.DC.IV.'Vingerafdruk: 160708 - # a1 *2 æfi : # a2 *5 sli - # 1b1 A n : # 1b2 Z5 tare, - # 2b1 a a : # 2b2 b5 umJohannes Bernaerts, Ad AnicI ManlI Severini BoetI de consolatione philosophiæ libros V. commentarius (f. K1 recto - b5 verso) ; Iulius Martinaus Rota (Vita Boetii)Herkomst: Bibliotheca Dominicana ; Ex libris Jacobi Vanderhaeghen postoris ... ; Ex libris Augustini Thierens ... ; Francisi Dhers [?] ; prijsboek Mario le Mort Gandavensi ... i aula Gymnasi Societatis Jesu ... 1753Simoni, Anna E. C. (comp.) Catalogue of books from the Low Countries 1601-1621 in the British library ; B202Imhof, D. Editions of classical authors by Jan I Moretus, 270Europeana-GoogleBook
sj-doc-1-aat-10.1177_24723444221103684 – Supplemental material for Effects of Carbon Chain Length of Acrylate Monomer on Sizing Properties of Locust Bean Gum-g-P(AA-co-Acrylate)
No full textSupplemental material, sj-doc-1-aat-10.1177_24723444221103684 for Effects of Carbon Chain Length of Acrylate Monomer on Sizing Properties of Locust Bean Gum-g-P(AA-co-Acrylate) by Haojie Lu, Zhihao Ji, Manli Li, Enqi Jin and Jiu Zhou in AATCC Journal of Research</p
Abstract 4659: Detection of autoantibodies against tumor-associated antigens (TAAs) improving immunodiagnosis in human osteosarcoma by serological proteome analysis
No full textAbstract
Osteosarcoma (OS) is the most common malignant primary solid bone-tumor. Despite its relatively low incidence rate among overall cancers, it remains one of the most harmful primary malignant tumors in childhood and adolescence. Thus, a critical need in the diagnosis and management of OS is to determine an optimal combination of clinical biomarkers that could detect tumors early with high specificity/sensitivity and with limited invasiveness. The objective of this study is to identify and characterize the targeted tumor-associated antigens (TAAs) as biomarkers in OS by serological proteome analysis (SERPA) approach, and further to analyze the frequency and specificity of anti-TAA antibodies in OS patients. In this initial study, autoantibodies to 29 TAAs were detected by ELISA and Western blotting in 90 sera from patients with OS, Osteochondroma (OC), and age matched normal individuals. Only 8 protein antigens including DSF70, HMGB1, HCC1, RalA, c-myc, AnnexinA1, IMP1, PBP, can induce significantly higher antibody responses in OS patients compared to normal individuals, achieving the highest sensitivity and specificity, 66% and 95%, respectively. The cumulative positive rate of autoantibodies against these eight selected TAAs in OS reached 70.7% with an observed AUC of 0.972 (95% CI: 0.867-0.988), significantly higher than that in normal control sera. Positive results were also confirmed by Western blotting. These preliminary data extensively evidence that not all proteins identified in cancer can be used as TAA biomarkers in OS, and only some of these proteins can induce immune responses, which could be potential TAAs in OS immunodiagnosis or prognosis, and further studies of novel targeted proteins in OS are currently in progress by SERPA approach. In addition, it supports the hypothesis that a customized TAA array can be used for enhancing anti-TAA antibodies detection, and it may constitute a promising and powerful tool for immunodiagnosis of OS.
Citation Format: Jitian Li, Manyu Huang, Manli Luo, Liping Dai, Wen Xie, Xiaofei Qin, Zongchang Han, Wuyin Li, Jianying Zhang. Detection of autoantibodies against tumor-associated antigens (TAAs) improving immunodiagnosis in human osteosarcoma by serological proteome analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4659. doi:10.1158/1538-7445.AM2017-4659</jats:p
On the Prospects of the Development of Non-public Ownership Economy under the Background of Big Data
Get PDFThis article analyzes the interaction between big data and the non-public economy. The author studied the problems faced in the deep fusion process. The research content of this paper includes data source activation, data cleanup, hidden dangers of data content, shortage of talents for analysis, and development of integrated platforms. The author analyzes how to establish a comprehensive development platform, improve the in-depth integration model, enhance the awareness of data application, do a good job in personnel training, improve the safety management mechanism, optimize the resource development environment, and do a good job in market supervision and management. The purpose of this article is to speed up the integration of big data and the non-public economy, and promote the development of enterprise economy
Viruses 7
Get PDFLysine residues in N-terminal tail of a viral histone H4 are crucial in controlling host gene expressionRahul Hepat, Yonggyun KimHeat-shock protein 90 is a broadly active regulator for baculovirus infectionShufen Li, Dianhai Hou, Fei Deng, Hualin Wang, Manli Wang, Zhihong HuDevelopment and immunity-related microRNAs of the lepidopteran model host Galleria mellonellaKrihnendu Mukherjee and Andreas VilcinskasThe sf122 gene of Spodoptera frugiperda nucleopolyhedrovirus modulates key aspects of insect-toinsect transmission and post mortem host liquefactionInés Beperet, Oihane Simón, Trevor Williams, Sarah L. Irons, Leopoldo Palma, Miguel López-Ferber, Linda A. King, Primitivo CaballeroEffect of a Viral Encoded Protein Kinase on Gene Expression in Amsacta moorei Entomopoxvirus Infected CellsHacer Muratoglu, Remziye Nalcacioglu, Basil Arif, Zihni DemirbagFP25K acts as a negative regulator in the infectivity improvement of AcMNPV Budded virusesShufen Li, Manli Wang, Zhihong Hu, Fei Deng, Hualin WangThe leucines in the transmembrane domain of Autographa californica nucleopolyhedrovirus Ac76 are important for intranuclear microvesicle formationDenghui Wei, Yan Wang, Xiaomei Zhang, Meijin YuanHigh-throughput purification of dsRNA against sacbrood virus disease in honey bees Apis cerana (Hymenoptera: Apidae)Jianqing Zhang, Yi Zhang and Richou Ha
Misdiagnosed atypical paroxysmal kinesigenic dyskinesia: a case report
No full textFen Pan,1,2 Shangda Li,3 Haimei Li,3 Yi Xu,1,2 Manli Huang1,2 1Department of Psychiatry, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; 2The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou 310003, China; 3School of Medicine, Zhejiang University, Hangzhou 310000, China Background: Paroxysmal kinesigenic dyskinesia (PKD) is characterized by sudden episodes of involuntary movements. PKD is a very rare movement disorder, and correct clinical diagnosis is often a challenge. Case: We present the case of a 23-year-old female with PKD. The patient showed episodes of twisting movements for 3 years. The symptoms lasted for about 5–10 minutes and subsided spontaneously. She was diagnosed as having epilepsy, and depressive and anxiety disorders successively. However, her symptoms did not alleviate after taking sodium valproate and antidepressants. Though there were no mutations in her PRRT2 gene, carbamazepine was used for treatment and was effective in controlling her symptoms. Conclusion: The clinical features of PKD patients are not always typical; therefore, it is important to distinguish PKD from the other subtypes of paroxysmal dyskinesia and psychogenic disorders. Keywords: paroxysmal kinesigenic dyskinesia, misdiagnosis, PRRT2 gen
Wu hua tian bao Old is new dao lan xin gu gong Guidebook = Old is new dao lan xin gu gong Guidebook
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Do Free Users Make Seller Pay? The Asymmetry Network Effect of Free Users on Fee Sellers in Business-to-Business Electronic Platform
Get PDFWith the prosperity of worldwide e-commerce, platforms generally conduct premium model to convert customer assets. Extant research has investigated the network effect at e-commerce platform, but no study to date has analyzed whether the influx of free users can stimulate sellers to pay for the membership or backfire. In the context of B2B electronic market, we examine the dynamic network effect of free users in different participation quality on fee sellers with a VAR model. The results show that (1) the rise of registered regular sellers can incite more fee sellers to pay for the membership than that of regular buyers; (2) external users attracted by advertising (search advertising and social media advertising in this paper) can impact targeted internal user base. These findings emphasize more exploration should be pay attention to the engagement quality of user base in two-sided markets, and provide guidance related to advertising strategy
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