1,987 research outputs found
Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications
No full textLi, Yujie, Nie, Rui-E, Lu, Yuanyuan, Lee, Seunghyun, Zhao, Zhengyu, Wu, Ling, Sun, Hongying, Bai, Ming (2022): Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications. Zootaxa 5138 (3): 324-338, DOI: https://doi.org/10.11646/zootaxa.5138.3.
FIGURE 3 in Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications
No full textFIGURE 3. Inferred secondary structure of tRNA-Ser1 (AGN) in seven new mitogenomes and tRNA-Val in the An. russiventris mitogenome.Published as part of Li, Yujie, Nie, Rui-E, Lu, Yuanyuan, Lee, Seunghyun, Zhao, Zhengyu, Wu, Ling, Sun, Hongying & Bai, Ming, 2022, Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications, pp. 324-338 in Zootaxa 5138 (3) on page 331, DOI: 10.11646/zootaxa.5138.3.6, http://zenodo.org/record/655977
FIGURE 7 in Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications
No full textFIGURE 7. Phylogenetic tree produced using maximum likelihood (ML) and Bayesian (BI) methods based on amino acids of 13 PCGs. The numbers on the left are Bayesian posterior probabilities (PP), and those on the right are maximum likelihood bootstrap values (BS). Asterisk indicates that this node is different in ML and BI.Published as part of Li, Yujie, Nie, Rui-E, Lu, Yuanyuan, Lee, Seunghyun, Zhao, Zhengyu, Wu, Ling, Sun, Hongying & Bai, Ming, 2022, Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications, pp. 324-338 in Zootaxa 5138 (3) on page 334, DOI: 10.11646/zootaxa.5138.3.6, http://zenodo.org/record/655977
FIGURE 4. Saturation plots for 2 rRNA gens, 13 in Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications
No full textFIGURE 4. Saturation plots for 2 rRNA gens, 13 protein-coding genes, and a concatenated dataset (from 13 protein-coding genes), left to right. The plot shows uncorrected pairwise divergences in transitions (s) and transversions (v) against divergences calculated with the GTR model. Green, transversions; blue, transitions.Published as part of Li, Yujie, Nie, Rui-E, Lu, Yuanyuan, Lee, Seunghyun, Zhao, Zhengyu, Wu, Ling, Sun, Hongying & Bai, Ming, 2022, Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications, pp. 324-338 in Zootaxa 5138 (3) on page 331, DOI: 10.11646/zootaxa.5138.3.6, http://zenodo.org/record/655977
FIGURE 5 in Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications
No full textFIGURE 5. Heterogeneous sequence divergence with nucleotides dataset and amino acids dataset of 13 PCGs of all taxa. The pairwise Aliscore scores are represented by colored squares. The scores range from -1, indicating full random similarity (dark blue), to +1, indicting non-random similarity (bright orange).Published as part of Li, Yujie, Nie, Rui-E, Lu, Yuanyuan, Lee, Seunghyun, Zhao, Zhengyu, Wu, Ling, Sun, Hongying & Bai, Ming, 2022, Seven new mitochondrial genomes of phytophagous scarab beetles (Coleoptera Scarabaeidae) and phylogenetic implications, pp. 324-338 in Zootaxa 5138 (3) on page 332, DOI: 10.11646/zootaxa.5138.3.6, http://zenodo.org/record/655977
Fig. 4 in Origin and cross-species transmission of bat coronaviruses in China
No full textFig. 4 Inter-family host switches. Strongly supported host switches between bat families for α-CoVs (a) and β-CoVs (b). Arrows indicate the direction of the switch; arrow thickness is proportional to the switch significance level, only host switches supported by strong Bayes factor (BF)> 10 are shown. Histograms of total number of host-switching events (state changes counts using Markov jumps) from/to each bat family along the significant inter-family switches for α-CoVs (c) and β-CoVs (d).Published as part of Latinne, Alice, Hu, Ben, Olival, Kevin J., Zhu, Guangjian, Zhang, Libiao, Li, Hongying, Chmura, Aleksei A., Field, Hume E., Zambrana-Torrelio, Carlos, Epstein, Jonathan H., Li, Bei, Zhang, Wei, Wang, Lin-Fa, Shi, Zheng-Li & Daszak, Peter, 2020, Origin and cross-species transmission of bat coronaviruses in China, pp. 4235 in Nature Communications 11 (1) on page 6, DOI: 10.1038/s41467-020-17687-3, http://zenodo.org/record/465766
Raman spectroscopy and periodic surface structures of Mg:ZnO thin film fabricated by femtosecond laser pulses
No full textMg doped ZnO thin films were prepared by magnetron sputtering and were irradiated by linearly polarized femtosecond laser pulse. Scanning electron microscopy (SEM) characterizations illustrated that regularly arranged nanoripples appeared on the ablation area with the period perpendicular to the polarization direction in the range of 250 nm~570 nm, but parallel to the polarization direction in the range of 2.2 μm~2.5 μm. The redshift of Raman peaks was observed at the central ablation area of the nanoripples, while, both blueshift and redshift were found at the edge area, which could be ascribed to the defects as well as the nanoripple structure
Microstructure Evolution and In Situ Resistivity Response of 2196 Al-Li Alloy during Aging Process
No full textThe microstructure evolution of 2196 Al-Li alloy during aging was investigated by microhardness test, transmission electron microscope (TEM) analysis and in situ resistivity measurement. The results showed that the resistivity of the 2196 Al-Li alloy during aging rapidly decreased during the first few hours, and then gradually increased after reaching the minimum value, which is temperature−dependent. The microstructure of the alloy was dominated by the δ′ phase after aging at 160 °C for 2 h while the T1 phase could hardly be seen until it had been aged for 16 h. As the aging time went on, significant ripening appeared for the δ′ phase while typical growth could be observed for the T1 phase. The increase in the resistivity of the 2196 Al-Li alloy during aging was attributed to the stronger electron scattering capacity of the T1 precipitation and the coupling effect between the T1 and δ′ phases
A VLSI architecture of JPEG2000 encoder
No full textCopyright @ 2004 IEEEThis paper proposes a VLSI architecture of JPEG2000 encoder, which functionally consists of two parts: discrete wavelet transform (DWT) and embedded block coding with optimized truncation (EBCOT). For DWT, a spatial combinative lifting algorithm (SCLA)-based scheme with both 5/3 reversible and 9/7 irreversible filters is adopted to reduce 50% and 42% multiplication computations, respectively, compared with the conventional lifting-based implementation (LBI). For EBCOT, a dynamic memory control (DMC) strategy of Tier-1 encoding is adopted to reduce 60% scale of the on-chip wavelet coefficient storage and a subband parallel-processing method is employed to speed up the EBCOT context formation (CF) process; an architecture of Tier-2 encoding is presented to reduce the scale of on-chip bitstream buffering from full-tile size down to three-code-block size and considerably eliminate the iterations of the rate-distortion (RD) truncation.This work was supported in part by the China National High Technologies Research Program (863) under Grant 2002AA1Z142
Abstract 2319: Deficiency of protease-activated receptor 2 signaling sensitizes EGFR-TKI-induced apoptosis in colorectal cancer
No full textAbstract
Colorectal carcinoma (CRC) patients show resistance to EGFR-TKI (epidermal growth factor receptor -tyrosine kinase inhibitor) treatment. Protease-activated receptor 2 (PAR2) has been shown to transactivate EGFR. We aim to investigate whether PAR2 sensitizes EGFR-TKI-induced apoptosis in CRC. Firstly, inhibition of PAR2 with shRNA or ENMD-1068 (a selective antagonist of PAR2) significantly sensitized EGFR-TKI (gefitinib or AG1478)-induced apoptosis, which was measured with Annexin V/ PI staining and activation of caspase-3 in different CRC cell lines. In xenograft tumor model, gefitinib treatment dramatically reduced the tumor volume in HT-29-shPAR2 compared with HT-29-vector. Mechanism study showed that PAR2 knockdown significantly reduced bcl-xL expression at both mRNA and protein level. Consistently, activation of PAR2 upregulated bcl-xL. Furthermore, inhibition of protein phosphatase (PP) with okadaic acid significantly downregulated bcl-xL. Moreover, knockdown of PP1 with siRNA blocked PAR2-induced accumulation of bcl-xL. In summary, our findings suggest that inhibition of PAR2 sensitizes EGFR-TKI-induced apoptosis via downregulation of bcl-xL in colorectal cancer. Considering the extensive expression of PAR2 and PAR2-activating proteases in colon, it strongly indicates that inhibition of PAR2 may be a potential avenue to overcome EGFR-TKI resistance in patients with CRC.
Citation Format: Weiwei Li, Yiming Ma, Longmei He, Hongying Wang. Deficiency of protease-activated receptor 2 signaling sensitizes EGFR-TKI-induced apoptosis in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2319. doi:10.1158/1538-7445.AM2017-2319</jats:p
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