162,328 research outputs found
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Content Based Image Retrieval for Dynamic Time Series Data
No full textLessmann B, Nattkemper TW, Huth J, et al. Content Based Image Retrieval for Dynamic Time Series Data. In: Proceedings of BVM. 2006: 61-65
Asthma With Bronchial Hypersecretion: Expression of Mucins and Toll-Like Receptors in Sputum and Blood [Corrigendum]
No full textCrespo-Lessmann A, Mateus E, Torrejón M, et al. J Asthma Allergy. 2017;10:269–276.
Page 269, Abstract, Materials and methods section, line two, the text “19 with bronchiectasis” should read “19 with bronchial hypersecretion”.
The authors apologize for this error
Glyoxal is an important allergen for (medical care) cleaning staff
No full textWhile disinfection is essential in medical practice, it carries the risk of serious adverse effects, including allergic contact dermatitis. To assess the current importance of glyoxal [CAS 107-22-2] as occupational allergen, a retrospective descriptive analysis of records of an occupational dermatitis clinic in Osnabruck and of national surveillance data of the Information Network of Departments of Dermatology (IVDK) in Germany and Austria was performed. Of 189 highly selected patients with occupational dermatitis tasted with glyoxal (1% in water or, as trimer, 1% in petrolatum) in Osnabruck, 11 had positive reactions to glyoxal, which were occupationally relevant in 9 cases. Causative occupations included mainly nursing and room cleaning. In a less selected population of 2626 additional patients tested in other centres of the IVDK, 40 further positive reactions to glyoxal were observed. Concomitant sensitisation to glutardialdehyde and formaldehyde, respectively, was frequently observed. In conclusion, glyoxal should be tested in all patients with contact dermatitis working in occupations with possible exposure to respective disinfecting/cleaning agents
Contact sensitization to N-(cyclohexylthio)phthalimide - Results of a multicentre study of the Information Network of Departments of dermatology (IVDK) and the German Contact Dermatitis Research Group (DKG)
No full textPrevious reports revealed relative high sensitization rates to the rubber chemical N-(cyclohexylthio)phthalimide (CTP; CAS-No. 17796-82-6), but the relevance of positive reactions remained unknown. It was discussed whether the test concentration of 1% pet. needed to be changed. The German Contact Dermatitis Research Group (DKG) added CTP in 3 concentrations, i.e. 0.25% pet., 0.5% pet, 1% pet., to the rubber series. From June 1999 to December 2000, 1936 patients in 30 departments of dermatology were tested with CTP. Of the 56 patients with a positive test reaction (2.9%), 52 reacted to CTP 1% pet., 21 to CTP 0.5% pet., and 9 to CTP 0.25% pet. The reaction indices were about the same with all concentrations. 34 patients with a positive reaction to CTP 1% pet. did not react to the lower concentrations. The majority of these reactions are probably false-positive. With CTP 0.25% pet., however, the majority of true allergic reactions to CTP were missed. Analysis of population characteristics and concomitant sensitizations to other rubber chemicals led to the conclusion that a positive reaction to CTP 0.5% pet. was a good indicator of contact allergy to CTP. Thus, the DKG decided to continue patch testing with CTP 0.5% pet. in the rubber series. Manufacturers' information about the use of CTP seem to partly contradict the patients' characteristics seen in this study. So the relevance of positive CTP patch test reactions, and the causative exposures in patients with CTP allergy, still remain to be clarified
para-phenylenediamine: the profile of an important allergen. Results of the IVDK
No full textBackground para-Phenylenediamine (PPD) is an important contact allergen and primarily used in hair dyeing. Objectives To quantify cases of contact allergy (CA) to PPD attributed to sources of exposure. Methods Patients with PPD CA, diagnosed by the Information Network of Departments of Dermatology (IVDK; n = 3307 of 83 030 patients tested), were divided into five subgroups of exposure. Demographic variables and pattern of concomitant reactions were used to characterize the subgroups further. The impact of individual factors on the risk of PPD CA was examined with a logistic regression analysis. Clinical epidemiology and drug utilization research (CE-DUR) methods were employed to estimate the 10-year prevalence of PPD CA in the general population. Results The 4% prevalence of PPD CA in patients was extrapolated to a prevalence of 0.96% in the general population. The defined profiles were found to 'explain' the following percentages of PPD CA: (i) hair dyeing in clients 22% (0.2% of the general population); (ii) different occupational exposures, namely hair dyeing by hairdressers, paint- and rubber-associated exposures 23% (0.22% of the general population); (iii) clothing/shoes 12% (0.12% of the general population). A probable causal exposure to PPD could not be identified in about 44% of patients with PPD CA. Conclusions In more than 50% of cases of PPD CA, a (very) probable causal exposure was identified. In the large remainder (44%) this was not possible. 'Historical' CA without current relevance and active sensitization through patch testing (a further important exposure to PPD) must be considered in these patients
Benchmarking state-of-the-art classification algorithms for credit scoring: an update of research
No full textMany years have passed since Baesens et al. published their benchmarking study of classification algorithms in credit scoring [Baesens, B., Van Gestel, T., Viaene, S., Stepanova, M., Suykens, J., & Vanthienen, J. (2003). Benchmarking state-of-the-art classification algorithms for credit scoring. Journal of the Operational Research Society, 54(6), 627–635.]. The interest in prediction methods for scorecard development is unbroken. However, there have been several advancements including novel learning methods, performance measures and techniques to reliably compare different classifiers, which the credit scoring literature does not reflect. To close these research gaps, we update the study of Baesens et al. and compare several novel classification algorithms to the state-of-the-art in credit scoring. In addition, we examine the extent to which the assessment of alternative scorecards differs across established and novel indicators of predictive accuracy. Finally, we explore whether more accurate classifiers are managerial meaningful. Our study provides valuable insight for professionals and academics in credit scoring. It helps practitioners to stay abreast of technical advancements in predictive modeling. From an academic point of view, the study provides an independent assessment of recent scoring methods and offers a new baseline to which future approaches can be compared
Contact sensitization to N-(cyclohexylthio)phthalimide - Results of a multicentre study of the Information Network of Departments of dermatology (IVDK) and the German Contact Dermatitis Research Group (DKG)
No full textPrevious reports revealed relative high sensitization rates to the rubber chemical N-(cyclohexylthio)phthalimide (CTP; CAS-No. 17796-82-6), but the relevance of positive reactions remained unknown. It was discussed whether the test concentration of 1% pet. needed to be changed. The German Contact Dermatitis Research Group (DKG) added CTP in 3 concentrations, i.e. 0.25% pet., 0.5% pet, 1% pet., to the rubber series. From June 1999 to December 2000, 1936 patients in 30 departments of dermatology were tested with CTP. Of the 56 patients with a positive test reaction (2.9%), 52 reacted to CTP 1% pet., 21 to CTP 0.5% pet., and 9 to CTP 0.25% pet. The reaction indices were about the same with all concentrations. 34 patients with a positive reaction to CTP 1% pet. did not react to the lower concentrations. The majority of these reactions are probably false-positive. With CTP 0.25% pet., however, the majority of true allergic reactions to CTP were missed. Analysis of population characteristics and concomitant sensitizations to other rubber chemicals led to the conclusion that a positive reaction to CTP 0.5% pet. was a good indicator of contact allergy to CTP. Thus, the DKG decided to continue patch testing with CTP 0.5% pet. in the rubber series. Manufacturers' information about the use of CTP seem to partly contradict the patients' characteristics seen in this study. So the relevance of positive CTP patch test reactions, and the causative exposures in patients with CTP allergy, still remain to be clarified
Patch testing with metalworking fluids from the patient's workplace
No full textIn view of the wide variety of components currently used in metalworking fluids (MWF), relevant contact sensitizations may be overlooked, because commercially available MWF test series cannot cover the full spectrum. Hence, patch testing with MWF from the patient's workplace is an important additional diagnostic tool. However, recommendations on how to perform such patch tests vary. We retrospectively analyzed patch test data of the Department of Dermatology in Dortmund, 1992-2003. In 141 metalworkers tested because of suspected occupational contact dermatitis due to MWF, 829 patch tests with 306 samples of MWF were performed. Water-based MWF (wb MWF) were mainly tested in 2 dilution series, i.e. pure (workplace concentration), 10% aq. and 1% aq., and pure, 50% aq. and 10% aq. Positive reactions to wb MWF occurred in 27 patients. Patch testing with wb MWF at workplace concentration resulted in 16.1% (39/242) positive reactions, with a positivity ratio of 69% and a reaction index of 0. From the analysis of reaction patterns and concomitant reactions, we conclude that most of these positive reactions indicated true contact allergy. With lower concentrations, relevant allergic reactions may be missed. Neat oils were tested as is or diluted from 1 to 50% in olive oil, but no reactions at all were observed. For optimum benefit of patch testing with MWF from the patient's workplace, breakdown testing is recommended. To overcome the time-consuming difficulties associated with this procedure, we propose a centre for information and documentation of contact allergies due to occupational exposure. Furthermore, full declaration of MWF ingredients is desirable
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