1,721,265 research outputs found
Cellular kinetics for a biological classification of lymphoma [La cinetica cellulare per una classificazione biologica dei linfomi]
No full text
Retinoblastoma gene family expression in lymphoid tissues
No full textIt appears more and more clear that retinoblastoma (RB) family of proteins represents key molecules in tumour suppression. This family consists of pRb/p105, p107 and pRb2/p130, which participate in a gene regulatory network that governs the cellular response to antimitogenic signals, and whose deregulation constitutes one of the hallmarks of cancer. Irrespective of their structural and biochemical similarities, RB proteins carry out different functional tasks. The expression of RB gene family in the reactive lymphoid tissues again confirms the different role of each member in cell cycle control and differentiation of normal cells. These different functional properties appear to be maintained in tumours lymphoid tissues, where alterations of the RB/p105 gene appear to be relatively rare. In this review, we will summarize the current knowledge about the role of the RB proteins in reactive and neoplastic lymphoid tissue
Pseudolymphoma, lymphocytic lymphoma, immunoblastic lymphoma: Disease progression [Pseudolinfoma, linfoma linfocitico, linfoma immunoblastico; progressione di malattia]
No full textLa prevenzione del carcinoma della prostata. Il paziente, il medico ed il management: esigenze a confronto.
No full text
Monitoraggio intensivo sull’utilizzo di farmaci antipsicotici atipici: valutazione della continuità assistenziale nel percorso prescrizione-erogazione. Un’esperienza nella asl na2 nord.
No full textRevised European-American Lymphoma Classification
No full textThe recently proposed Revised European-American Lymphoma Classification represents a serious attempt to overcome the controversies that have divided both pathologists and clinicians over the past three decades. It was formulated by 19 experienced hematopathologists, who agreed on a list of clinicopathologic entities, all well known from the literature and daily practice. Compared with previous schemes, the Revised European-American Lymphoma Classification offers the following advantages: 1) it incorporates all nodal and extranodal lymphoid tumors, including Hodgkin's disease; 2) it is histogenetically updated by recognizing new categories (such as the mantle cell category) and grouping tumors that need further validation to be considered as separate entities (eg, diffuse large B-cell lymphomas); 3) it avoids any morphologic grading, the clinical course of lymphomas being influenced by factors other than histology (tumor burden, cell kinetics, apoptotic rate, and so forth) and 4) it includes all molecular data (phenotype, genotype, cytogenetics, and so forth), which can assist in the diagnosis
- …
