3,459 research outputs found
Letter of concern from Boris Drasin, President of the Jersey Homesteads Industrial Cooperative Association
No full textJersey Homesteads (later renamed the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whome had emigrated from Europe. In this letter, Boris Drasin, a community leader who was the President of the Jersey Homesteads Industrial Cooperative Association, expresses his concerns to their management corporation (Consumers Wholesale Clothiers, Inc.) about how financial losses will impact the lives of Roosevelt's residents, three-fourths of whom depended on the garment factory for their livelihoods. He makes suggestions as to how the situation might be improved
Widespread Expression of BORIS/CTCFL in Normal and Cancer Cells
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Boris Smolar papers, undated, 1913-1985.
No full textThis collection contains materials pertaining to the life and career of Boris Smolar, a journalist and editor-in-chief of the Jewish Telegraphic Agency and an author of children's books.Gift of Leivy Smolar
Long-Run Development and the New Cultural Economics
No full textThis paper reviews recent economics literature on culture, with an emphasis on its relation to the field of long-run growth and development. It examines the key issues debated in the new cultural economics: causal effects of culture on economic outcomes, the origins and social costs of culture, as well as cultural transmission, persistence, and change. Some of these topics are illustrated in application to the economic analysis of envy-related culture
Making Enterprise Information Systems Resilient Against Disruptive Events: A Conceptual View
No full textEnterprise Information Systems (EIS) are designed to deal with normal variability in their inputs and data. Empowered by CONTEXT-AWARENESS, some EIS even count on sensors and/or data analytics for capturing changes outside of the system. Nevertheless, context-awareness would often fail when EIS are affected by (large-scale) disruptive events, such as disasters, virus outbreaks, or military conflicts. Hence, in the current paper, we take a step forward, by considering context-awareness for disruptive events. We combine context-awareness with risk management techniques, such as FMECA and FTA, that are useful for defining and mitigating risk events. To avoid having to define the likelihood for such very-low-probability disruptive risks, we use CONSEQUENCE-BASED RISK MANAGEMENT rather than traditional risk management. We augment this approach with the context-awareness paradigm, delivering a contribution that is two-fold: (i) We propose context-awareness-related measures and consequence-based-risk-management-related measures, to address disruptive events; (ii) We reflect this in a method featuring the application of context-awareness and risk management for designing robust and resilient EIS.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Policy Analysi
Illustrated book of fiction, Boris Vian-Froth on the Daydream
No full textBakalářká práce Ilustrovaná kniha beletrie se v praktické části zaměřuje na koncepci ilustrací a jejich následnou kresbu pro knihu Pěna dní autora Borise Viana. V teoretické části práce je detailně sledován proces vzniku od prvotních idejí až po hlavní koncepční řešení celku. Text zde dále zkoumá formu díla skrze technologický proces výroby až po konečnou realizaci knihy a dalšího příslušenství, které kniha nabízí. Krom procesu vzniku a tvorby text obsahuje také kontextové srovnání, autorčinu osobní výpověď a zhodnocení výsledného díla.OVUObhájenoBachelor´s thesis Illustrated book of fiction in it´s practical part is aimed at conception of illustrations with following realisation of drawings for the book Froth on the Daydream by Boris Vian. In theoretical part the creation process of the book is observed there closely from the first ideas up to whole piece solution. Next part of the thesis is focused on technological process of manufacturing and final realisation of the book and it´s other accessories. Also the context comparison is described there as well as personal statement of the author and evaluation of the final work
Enforcing context-awareness and privacy-by-design in the specification of information systems
No full textNetworked physical devices, vehicles, home appliances, and other items embedded with electronics, software, sensors, actuators, and connectivity, allow for run-time acquisition of user data. This in turn can enable information systems which capture the “current” user state and act accordingly. The use of this data would result in context-aware applications that get fueled by user data (and environmental data) to adapt their behavior. Yet the use of data is often restricted by privacy regulations and norms; for example, the location of a person cannot be shared without given consent. In this paper we propose a design approach that allows for weaving context-awareness and privacy-by-design into the specification of information systems. This is to be done since the very early stages of the software development, while the enterprise needs are captured (and understood) and the software features are specified on that basis. In addition to taking into account context-awareness and privacy-sensitivity these two aspects will be balanced, especially if they are conflicting. The presented approach extends the “Software Derived from Business Components” (SDBC) approach. We partially demonstrate our proposed way of modeling, by means of a case example featuring land border security. Our proposed way of modeling would allow developers to smoothly reflect context and privacy features in the application design, supported by methodological guidelines that span over the enterprise modeling and software specification. Those features are captured as technology-independent societal demands and are in the end reflected in technology-specific (software) solutions. Traceability between the two is possible as well as re-use of modeling constructs.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Information and Communication Technolog
Computational genomics of regulatory elements and regulatory territories
No full textWhole genome comparison of metazoan genomes reveals extremely high level of noncoding conservation over tens to hundreds of base pairs across distant species. These sequences are termed as conserved noncoding elements (CNEs). Arrays of conserved noncoding elements that span the loci of developmental regulatory genes and their span defines regulatory genomic blocks (GRBs). CNEs are currently known to be involved in transcriptional regulation and development as long-range enhancers. However, no molecular mechanism can yet explain their exceptional degree of conservation. As a first step towards the genome-wide study of these elements, I developed two R/Bioconductor packages CNEr and TFBSTools, to detect and analyse regulatory elements. Next, I designed a novel CNE detection pipeline for duplicated regions in the ameiotic Adineta vaga genome. Identification of CNEs in this genome suggests that the principal function of CNEs is regulation of developmental gene expression rather than copy number sensing. In addition, I performed a de novo genome annotation of European common carp Cyprinus carpio. This genome stands as an ideal candidate for comparative study of zebrafish genome. Its analysis revealed a wealth of previously undetected fish regulatory elements and their unexpectedly high level of conservation between the two genomes. Finally, I presented a computational method for the identification of GRB boundaries and prediction of the corresponding target genes under long-range regulation. The predicted target genes are implicated in developmental, transcriptional regulation and axon guidance. The disruption of regulation of these target genes is likely to cause complex diseases, including cancer. The GRB boundaries and predicted target genes are valuable resource for investigating developmental regulation and interpreting genome-wide association studies.Open Acces
Organisation and evolution of landscapes of gene regulation
No full textThe control of developmentally expressed genes is highly complex, requiring input from multiple layers of regulation. Among the least understood of those layers are long-range enhancer-promoter interactions and the organisation of the architecture of chromatin folding. Alterations in these aspects of regulation are likely to underlie the establishment of differences across a range of contexts, from determining cell fate to defining species-specific traits. The CTCF protein and the cohesin complex play key roles in defining 3D chromatin architecture, and are thought to be critical in directing patterns of gene expression. Yet, previous cohesin and CTCF depletion studies cast doubt on their importance in this context. In this thesis I show, using thymocyte differentiation as a model, how developmentally regulated genes are particularly sensitive to cohesin and CTCF, providing evidence regarding the importance of cohesin, CTCF and general 3D structure in the coordination of complex regulation. I uncover surprising dissimilarity in the identities of genes affected by each depletion, and demonstrate how this is caused by differences in how each depletion affects 3D structure, further highlighting how 3D space influences gene expression. I then focus on how changes in long-range regulation occur over evolutionary timescales. I Identify signatures of acceleration in otherwise conserved elements across mammals, presenting evidence that a subset of generally conserved elements are predisposed to shifts in selection pressure. Across studied species these regions are particularly enriched for activity in the developing brain. Furthermore, I show how GC-biased gene conversion is a regular source of lineage-specific gain in CpG Islands in conserved elements for a subset of species. This is further evidence that the repurposing of existing elements is a viable route through which evolutionary innovation occurs. Taken together, this work reveals detailed aspects of the organisation of long-range regulation, both in nuclear space and over evolutionary time.Open Acces
Biblical reception in rock-poetry: Boris Grebenshchikov
No full textThe article is devoted to the problem of biblical reception in Russian rock-poetry. Having analyzed Boris Grebenshikov’s interviews and texts, the author highlights his specific strategies for «alien» words interiorization. The article tells about biblical code and mechanisms of biblical text interiorization in Boris Grebenshchikov rock-poetry. The originality of individual creative manner of the rock-poet is revealed through the aspect of poetics under consideration
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