741 research outputs found
The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation
No full textGlucose provides an essential nutrient source that supports glycolysis and the hexosamine biosynthesis pathway (HBP) to maintain tumour cell growth and survival. Here we investigated if short-term glucose deprivation specifically modulates the phosphatidylinositol 3-kinase/protein kinase B (PI3K/PKB) cell survival pathway. Insulin-stimulated PKB activation was strongly abrogated in the absence of extracellular glucose as a consequence of the loss of insulin-stimulated PI3K activation and short-term glucose deprivation inhibited subsequent tumour cell growth. Loss of insulin-stimulated PKB signalling and cell growth was rescued by extracellular glucosamine and increased flux through the HBP. Disruption of O-GlcNAc transferase activity, a terminal step in the HBP, implicated O-GlcNAcylation in PKB signalling and cell growth. Glycogenolysis is known to support cell survival during glucose deprivation, and in A549 lung cancer cells its inhibition attenuates PKB activation which is rescued by increased flux through the HBP. Our studies show that rerouting of glycolytic metabolites to the HBP under glucose-restricted conditions maintains PI3K/PKB signalling enabling cell survival and proliferation
A natural heritage assessment of wetlands and riparian areas in the Uncompahgre River Basin: eastern Montrose and Ouray counties, Volume 2
No full textIncludes bibliographical references.May 1999.Prepared for: Colorado Dept. of Natural Resources, by Thomas Stephens ... [et al.]
Developing Core Leadership Competencies for the Library Profession
No full textThe development of competencies, competency lists, or competency models has become a popular way to assess the strengths, needs, and potential contributions of individuals in an organization. The success of libraries as organizations is determined by the actions of the individuals who work in those libraries; the success of those individuals in carrying out the missions of those libraries is in large measure a reflection of the type and quality of leadership. Successful library leaders demonstrate certain skills that are instrumental in the delivery of desired outcomes. We usually think of the demonstration of these skills as competencies.
Creating a list of competencies for library leaders is a key objective envisioned in the strategic plan of the Library Leadership Administration and Management Association (LLAMA). This task was assigned to five members of the 2008 class of the American Library Association’s Emerging Leaders Program. The project is a critical first step toward a list of competencies or standards that would serve at least three types of users: library educators planning curricula, aspiring library leaders hoping to advance their careers, and experienced library leaders seeking to advance the profession. This article will provide an overview of the library literature addressing competency models, describe the process used to develop the competency model for library leadership, review competency models found in the literature of other professions, and discuss the proposed core competency model for leadership in our profession
1963 First Year Students
No full textBlack and white photo; unmounted.Back - Peter Saint, B. Matthews, Ron Leibich, G. Wyatt, Adrian Smith, Mal Cleggett, Jeff Gill, Jim Cawthorne, D. Brain, J. Derham, R. Stephens, Bryan Thomas, C. Downing, Bruce Thyer; middle - Greg Young, Max Clarke, Mal Kuerschner, Jim Hughes, Ed Smulders, Rick Laslett, Ian Wilson, Dave Kidd, B. Spry, Dave Ransom, Napier Mitchell, Keith Cowley, A. Wilkinson, C. Gregson, Dave Kleeman; front - R. Kruimink, Chris O'Donnell, Peter Cocker, B. Skinner, Barry Lawes, G. Dick, Mr. Herriot (Principal), Mr Hiddle (Housemaster), M. Smith, A. Thorpe, Paul Mannion, Len Snell, Geoff Walsh, Bob Sampson, Richard Baldwin; absent - Bruce Shepherd
Understanding the Executive Roles in Health Leadership
No full textGeorgia Southern University faculty members Gerard R. Ledlow and James H. Stephens co-authored Understanding the Executive Roles in Health Leadership in Leadership for Health Professionals: Theory, Skills, and Applications, Third Edition.
Book Summary: Leadership for Health Professionals: Theory, Skills, and Applications, Third Edition is the first textbook of its kind to apply classical knowledge of leadership theory and time-honored best practices of industry leaders to a health organization context. This comprehensive and well-organized text is grounded in real-world applications of theoretical concepts, and focuses on practical examples of leadership in actual healthcare scenarios.
Themes of leadership principles, applications and constructs such as organizational culture, cultural competency, ethical frameworks and moral practice, scientific methodology, leader competencies, external and internal assessment and evaluation, communication, planning, decision-making, employee enhancement, and knowledge management are woven through the entire text.
The authors of the Third Edition have over four decades of practical leadership experience in corporate and federal governmental health organizations from entry to executive levels, as well as over twenty-five years of academic experience as faculty in doctoral research institutions. Leadership for Health Professionals: Theory, Skills, and Applications, Third Edition utilizes the author-created learning model, Focused Content Cycling, which is the reiteration of key leader systems, actions and behaviors throughout the text using multiple learning modalities. This process provides additional learning potential within a leadership course with the intent to bridge theory with practice
Singing from the Grave: DNA from a 180 Year Old Type Specimen Confirms the Identity of Chrysoperla carnea (Stephens)
No full textCopyright: © 2015 Price et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article.NHM Repositor
1963 First Year Students
No full textBlack and white photo; unmounted.Back - Richard Baldwin, D. Brain, M. Clegget, Peter Cocker, G. Dick, C. Downing, Keith Cowley, Jim Cawthorne, Paul Mannion; third row - Chris O'Donnell, F. Kruimink, Dave Kleeman, Dave Kidd, Mal Kuerschner, C. Gregson, Geof Gill, Jim Hughes, Barry Lawes, Napier Mitchell, B. Matthews; second row - Bryan Thomas, Bruce Thyer, Adrian Smith, Peter Saint, M. Smith, Ed Smulders, Len Snell, B. Spry, Greg Young, R. Stephens, A. Thorpe, Bob Sampson; front - Dave Ransom, B. Skinner, Ron Liebich, A. Wilkinson, G. Wyatt, T. Wordley, Bruce Shepherd
Leadership Models in Practice
No full textGeorgia Southern University faculty members Gerard R. Ledlow and James H. Stephens co-authored Leadership Models in Practice in Leadership for Health Professionals: Theory, Skills, and Applications, Third Edition.
Book Summary: Leadership for Health Professionals: Theory, Skills, and Applications, Third Edition is the first textbook of its kind to apply classical knowledge of leadership theory and time-honored best practices of industry leaders to a health organization context. This comprehensive and well-organized text is grounded in real-world applications of theoretical concepts, and focuses on practical examples of leadership in actual healthcare scenarios.
Themes of leadership principles, applications and constructs such as organizational culture, cultural competency, ethical frameworks and moral practice, scientific methodology, leader competencies, external and internal assessment and evaluation, communication, planning, decision-making, employee enhancement, and knowledge management are woven through the entire text.
The authors of the Third Edition have over four decades of practical leadership experience in corporate and federal governmental health organizations from entry to executive levels, as well as over twenty-five years of academic experience as faculty in doctoral research institutions. Leadership for Health Professionals: Theory, Skills, and Applications, Third Edition utilizes the author-created learning model, Focused Content Cycling, which is the reiteration of key leader systems, actions and behaviors throughout the text using multiple learning modalities. This process provides additional learning potential within a leadership course with the intent to bridge theory with practice
Strategic Planning and Leadership
No full textGeorgia Southern University faculty members James H. Stephens and Gerard R. Ledlow co-authored Strategic Planning and Leadership in Introduction to Public Health Organizations, Management, and Policy.
Book Summary: Students pursuing a career in public health will be met with diverse and dynamic challenges. From the impact of a cholera outbreak after a natural disaster to promoting healthier lifestyles, protecting our communities will require our vigilance and creativity in finding new and better ways to address these complex problems. Led by series editor Dr. Carleen Stoskopf, PUBLIC HEALTH BASICS introduces undergraduate students to contemporary public health issues ranging from epidemiology, management, data analysis, and health promotion. Through this book series, students will grapple with the major public health issues we are facing locally and globally, while learning and putting into practice the principles of public health. INTRODUCTION TO PUBLIC HEALTH ORGANIZATIONS, MANAGEMENT, AND POLICY, the second offering in this new series, provides a detailed introduction to public health organizations and their management. Initial chapters are devoted to exploring foundational concepts, practical applications, and new directions in each domain. Subsequent chapters focus on public health organizations at all levels, from large federal organizations and research centers, to county and local public health agencies. In addition to providing a critical understanding of individual, group, and organization behavior, the author outlines effective approaches to facilitate and manage inevitable organizational change in a productive, sustainable way by applying knowledge of power, influence, motivation, and leadership. This text enhances your knowledge and skills in preparing for a successful career in public health
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