1,839 research outputs found
The efficacy of emamectin benzoate against infestations of Lepeophtheirus salmonis on farmed Atlantic salmon (Salmo salar L) in Scotland, 2002-2006
No full textInfestations of the parasitic copepod Lepeophtheirus salmonis, commonly referred to as sea lice, represent a major challenge to commercial salmon aquaculture. Dependence on a limited number of theraputants to control such infestations has led to concerns of reduced sensitivity in some sea lice populations. This study investigates trends in the efficacy of the in-feed treatment emamectin benzoate in Scotland, the active ingredient most widely used across all salmon producing regions. Study data were drawn from over 50 commercial Atlantic salmon farms on the west coast of Scotland between 2002 and 2006. An epi-informatics approach was adopted whereby available farm records, descriptive epidemiological summaries and statistical linear modelling methods were used to identify factors that significantly affect sea lice abundance following treatment with emamectin benzoate (SLICEH, Schering Plough Animal Health). The results show that although sea lice infestations are reduced following the application of emamectin benzoate, not all treatments are effective. Specifically there is evidence of variation across geographical regions and a reduction in efficacy over time. Reduced sensitivity and potential resistance to currently available medicines are constant threats to maintaining control of sea lice populations on Atlantic salmon farms. There is a need for on-going monitoring of emamectin benzoate treatment efficacy together with reasons for any apparent reduction in performance. In addition, strategic rotation of medicines should be encouraged and empirical evidence for the benefit of such strategies more fully evaluated
Narrow linewidth CW and Q-switched erbium-doped fibre loop laser
No full textThe authors report the operation of a single-frequency, diode-pumped laser in CW operation with a linewidth of 10kHz, which provides a prelase for a narrow linewidth Q-switched laser. This was achieved by incorporating an unpumped low Er3+-doped fibre. In Q-switched operation, a linewidth of less than 60MHz is reported for pulses of 1µs at a repetition rate of 960 Hz
Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.
No full textOverexpression of wild-type p53 prevents cells from entering the S phase of the cell cycle. The amino-terminal transactivation region of p53 is phosphorylated by several protein kinases, including DNA-PK, a nuclear serine/threonine protein kinase that in vitro requires DNA for activity. DNA-PK was recently shown to phosphorylate serines 15 and 37 of human p53 (Lees-Miller et al., 1992. Mol. Cell. Biol., 12, 5041-5049). To prevent phosphorylation at these sites, mutants were constructed that changed the codons for serine 15 or serine 37 to alanine codons. Expression of p53-Ala-37 in stably transformed T98G cells blocked progression of the cells into S phase as well as did the expression of wild-type p53. In contrast, p53-Ala-15 was partially defective in blocking cell cycle progression. Several cell clones transformed with the mutant p53-Ala-15 gene expressed normal levels of p53 mRNA but accumulated little or no detectable p53 protein. However, by using a transient expression system driven by a strong cytomegalovirus promoter, we showed that the inability of p53-Ala-15 to fully block cell cycle progression was not due to inadequate levels of expression or to a failure of the mutant protein to accumulate in the nucleus. These results suggest that phosphorylation of Ser-15 may affect p53 function
Cw ion lasers pumped by electron beams
No full textWe have obtained cw laser radiation from singly ionized Hg, I, Cd, Se, and As by exciting He metal-vapor mixtures with a dc electron beam. The beam is generated by glow discharge electron guns located apart from the active medium. This is the first time that cw ion laser action has been obtained using electron beam excitation
A stable narrow linewidth Q-switched Er-doped fibre laser
No full textQ-switched pulses of stable linewidths less than 60MHz were generated for repetition rates up to 1kHz, using low doped erbium fibre as a saturable absorber combined with CW prelase technique
CW laser action in atomic fluorine
No full textWe have obtained CW laser action on four transitions in the doublet system of atomic fluorine for the first time. All previously reported laser action was on a pulsed basis only. CW laser radiation was obtained when F2 or AgF was used as a fluorine donor in an electron beam pumped helium plasma. A multiline output power of 200 mW was obtained
CW silver ion laser with electron beam excitation
No full textA CW laser power of 140 mW was obtained in the 840.39 nm transition of Ag II by electron beam excitation. This electron beam excited metal vapor ion laser is capable of operating using metals with high vaporization temperatures and is of interest for generation of CW coherent radiation in the 220-260 nm spectral region
1-W cw Zn ion laser
No full textWe have obtained 1.2W of cw laser power on the 4911.6- and 4924.0-Å transitions of Zn II by exciting a He-Zn gas mixture with a dc glow discharge electron beam. In addition, 0.25-W output power has been obtained on the 6149.9-Å line of Hg+ using the same excitation scheme. The combination of electron beam ionization of rare gas atoms and subsequent charge transfer excitation to metal ion levels is shown to have the potential of significantly increasing the efficiency of ion lasers. cw multiwatt visible and ultraviolet ion lasers operating at efficiencies > 10-3 appear feasible using this excitation scheme
Stabilization as a CW approximation
No full textAbstractThis paper describes a peculiar property of the category of S-modules constructed by the author, Kriz, Mandell, and May: the full subcategory of suspension spectra (all of which are S-modules) forms a precise copy of the category of topological spaces. Consequently, the “classical” homotopy category of S-modules with morphisms the actual homotopy classes of maps contains a copy of unstable homotopy theory. Stabilization and stable homotopy are induced by CW approximation as S-modules. One consequence is that CW complexes whose suspension spectra are CW S-modules must be contractible
Cw iodine ion laser excited by an electron beam
No full textCW laser oscillation has been obtained on the 5760.7 and6127.5 Å transitions of singly ionized iodine in an He-I2 plasma excited by a dc electron beam
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