81,532 research outputs found
Lee la lee 9
No full textEl propósito del número 9 del Magazín Lee la lee es aproximar a los maestros en formación al estudio del juego y del movimiento, a su importancia en la Educación Infantil y a la comprensión del lugar del maestro en las experiencias lúdicas y psicomotrices. El cuerpo y sus diferentes manifestaciones ocupan un lugar central en este espacio, así como el diseño de ambientes y los objetos como mediadores de la cultura en las interacciones entre los niños y el adulto
Secukinumab Response in Korean Patients with Moderate to Severe Plaque-Type Psoriasis Irrespective of Previous Biologic Use: 1-Year Experience at a Single Center
No full textSimulation of cylindrical plunge grinding based on the behaviour of cutting edge wear
No full textIn cylindrical plunge grinding, a series of workpieces are ground successively without intermediate dressing of the wheel. Through the grinding, the wheel characteristic is continuously changed by the wear, fracture and new exposure of abrasive grains, having a profound effect on the grains on wheel surfaces in the cylindrical grinding process are developed to make it possible to describe the time dependent results of grinding and to establish the grinding operation standards capable of estimating grinding wheel performance and selecting grinding conditions, in which many parameters in actual grinding operations are considered. This simulation system can display its results in graphical form including the time dependent results and the effects of various parameters as well as optimization capabilities. This simulation has the same effects as many grinding experiments, and capable of selecting the optimum grinding wheels and conditions
Unusual Case of Scalp Sarcoidosis with Alopecia: An Only Manifestation of Cutaneous Sarcoidosis without Systemic Involvement
No full textResponse to 'The incidence and survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide population-based matched cohort study in Korea'
No full textExchange-bias of NiFe/NiO bilayer
No full textExchange-bias (H-ex) of NiFe/NiO bilayers grown epitaxially on MgO(100) and MgO(111) have been measured in order to understand exchange biasing phenomena more clearly. According to HRXRD, the separate reflections of MgO and NiO were observed, which implied that NiO layers grew epitaxially on MgO substrates. The rms roughness (R-rms) of NiO on MgO(100) measured by AFM was 1.79 angstrom while that of NiO on MgO(111) was 17.85 angstrom. Despite a higher R-rms, the value of H-ex, 85 Oe in the case of NiFe/NiO on MgO(111) was larger than that of NiFc/NiO on MgO(100), 47 Oe, probably due to stronger effect of (111) texture of NiO surface. But low He,, of NiFe/NiO on MgO(111) implied that exchange biasing was generated by not only upcompensated spins but also compensated spins of NiO. He,, of NiFe/NiO bilayer grown on Si(100) was 118 Oe. According to SEM, grain size of NiO surface grown on Si(100) was very small, which mean its domain size was also very small. The explanation of the effect of domain size was consistent with random field model
Toma y lee
No full textSi hay un momento histórico paradigmático de la lectura como clave para encontrar el sentido de la vida, es Agustín de Hipona sin saber qué camino tomar y escuchando al otro lado del jardín una voz que repite: «Tolle, lege» (Toma y lee)
한국인 중증 건선 환자에서 생물학적 제제 치료 전환에 대한 임상적 특징과 치료 방향에 대한 후향적 단일기관 연구
No full textBackground: Since the advent of biologics, they have been an efficient treatment for severe psoriasis vulgaris. Psoriasis that is refractory to biologics is associated with factors, such as old age, a high initial psoriasis area and severity index, a high body mass index (BMI), and nail involvement. Objective: We evaluated the clinical characteristics and differences in laboratory parameters in patients witfi severe psoriasis who switched biologics at least once. Methods: We analyzed the demographics, medical records, and laboratory data of 29 Korean patients who had switched biologics. Patients were classified into two groups based on the number of times they switched to biologics. Results: The reasons for switching biologics in the 29 patients were primary failure (37.9%), secondary failure (58.6%), and occurrence of adverse events (3.5%). The multiple switching group showed higher mean values than the single switching group for the factors associated with low efficacy of biologics, such as age at initial presentation (43.4±9.6 years vs. 42.1 ±12.1 years), an initial psoriasis area severity index (15.3±6.3 vs. 12.9±4.4), and a BMI (27.4±4.0 kg/m2and 26.3±3.4 kg/m2), respectively. Conclusion: In this single-centered study, secondary failure was the most common reason for switching biologics. Higher mean values for factors affecting the efficacy of biologics were noted in the multiple switching group; however, the difference was not statistically significant. When choosing biologics for patients, dermatologists should be mindful of this as they select the second-line biologics
A putative secreted solute binding protein, SCO6569 is a possible AfsR2-dependent down-regulator of actinorhodin biosynthesis in Streptomyces coelicolor
No full textThe authors are very grateful to the technical support provided
by the ERC of Inha University.AfsR2 is a global regulatory protein involved in stimulating the biosynthesis of antibiotics in various Streptomyces species. Using 2-D gel electrophoresis and MALDI-TOF analyses, several putative AfsR2-target proteins were previously identified. In order to verify the biological significance of the proteomics-guided targets, the sixteen putative AfsR2 target genes were individually cloned under the strong-and-constitutive promoter (PermE(+)) of the Streptomyces expression vector, pSE34, followed by the transformation into both Streptomyces lividans and Streptomyces coelicolor. Among the putative AfsR2-target genes tested, the expression of a putative secreted solute binding protein, SCO6569 significantly repressed biosynthesis of actinorhodin in S. coelicolor, and the transcripts encoded by the pathway-specific activator, actll-ORF4 for actinorhodin were also reduced in SCO6569-overexpressing S. coelicolor. Moreover, SCO6569 gene-disruption in S. coelicolor further enhanced actinorhodin production, suggesting that the SCO6569 could be a possible AfsR2-dependent down-regulator acting in actinorhodin biosynthesis in S. coelicolor. (C) 2008 Elsevier Ltd. All rights reserved.This work was supported by the
Korean Systems Biology Program from the Ministry of Education,
Science and Technology through the Korea Science and Engineering
Foundation (No. M10309020000-03B5002-00000)
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