246 research outputs found
An Analysis of the Distribution of Woodland Caribou from Sighting Forms
No full textThe purpose of this report is to document the distribution of the woodland caribou in northern Saskatchewan and summarize the data collected on woodland caribou sighting forms compiled by Tim Trottier. Discusses in this report is: herd structure, sex and age observations, herd size, seasonal distribution and habitat preferences of the woodland caribou of northern Saskatchewan.Student paper submitted for WR 271
Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease
No full textTopical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease
No full textTopical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease
No full textWolf-Rayet spin at low metallicity and its implication for Black Hole formation channels
No full textArticleThis is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.Context. The spin of Wolf-Rayet (WR) stars at low metallicity (Z) is most relevant for our understanding of gravitational wave sources such
as GW150914, as well as the incidence of long-duration gamma-ray bursts (GRBs). Two scenarios have been suggested for both phenomena:
one of them involves rapid rotation and quasi-chemical homogeneous evolution (CHE), the other invokes classical evolution through mass loss
in single and binary systems.
Aims. The stellar spin of Wolf-Rayet stars might enable us to test these two scenarios. In order to obtain empirical constraints on black hole
progenitor spin we infer wind asymmetries in all 12 known WR stars in the Small Magellanic Cloud (SMC) at Z = 1/5Z⊙, as well as within a
significantly enlarged sample of single and binary WR stars in the Large Magellanic Cloud (LMC at Z = 1/2Z⊙), tripling the sample of Vink
(2007). This brings the total LMC sample to 39, making it appropriate for comparison to the Galactic sample.
Methods. We measure WR wind asymmetries with VLT-FORS linear spectropolarimetry, a tool uniquely poised to perform such tasks in extragalactic
environments.
Results. We report the detection of new line effects in the LMC WN star BAT99-43 and the WC star BAT99-70, as well as the famous
WR/LBV HD5980 in the SMC, which might be evolving chemically homogeneously. With the previous reported line effects in the late-type
WNL (Ofpe/WN9) objects BAT99-22 and BAT99-33, this brings the total LMCWR sample to 4, i.e. a frequency of ∼10%. Perhaps surprisingly,
the incidence of line effects amongst low Z WR stars is not found to be any higher than amongst the Galactic WR sample, challenging the
rotationally-induced CHE model.
Conclusions. AsWR mass loss is likely Z-dependent, our Magellanic Cloud line-effectWR stars may maintain their surface rotation and fulfill
the basic conditions for producing long GRBs, both via the classical post-red supergiant (RSG) or luminous blue variable (LBV) channel, as
well as resulting from CHE due to physics specific to very massive stars (VMS).We would like to thank the anonymous referee
for their constructive comments. This research made use of
the SIMBAD database, operated at CDS, Strasbourg, France. JSV is
funded by the Northern Ireland Department of Communities (DfC).
TJH was funded by ST/M0012174/1
Edges of the mind : psychic margins and the modernist aesthetic in Vernon Lee, Evelyn Underhill, May Sinclair, Dion Fortune and Jane Harrison.
No full textPhDThe question 'Where does she begin and I end, asked in Virginia Woolf's The Years, voices a modernist
concern with the limits of self-identity and related questions of egoism and altruism. In this thesis I argue
that this concern is informed by a pre-history of thinking about selfhood, psychic boundaries and the
spiritual mainly ignored by readings of modernism which map the psyche via psychoanalysis, or Freud's
'discovery of the unconscious'. Our thinking about the self has become colonised by the literary doctrines of
better known canonical figures of the modernist period, generating a way of thinking about the limits of the
psyche which is both literally and metaphorically circumscribed. A reading of more eccentric discourses
explicitly engaged in negotiating the boundaries of individuality can provide a history of the psychic
underpinnings to the modernist conception of the self. The representation of marginal states of
consciousness, or epiphanic moments, is crucial to the literature of modernism: interpretation of these altered
states, or edges, can be refigured through readings of Vernon Lee, Evelyn Underhill, May Sinclair, Dion
Fortune and Jane Harrison: five women writing between 1880-1930 for whom pre-Freudian forms of
dissolution and challenge to self-unity are palpably present in the form of telepathy, subliminal selves,
oceanic consciousness and internal multiplicity. In addition to writing non-fictional texts which variously
explore the psychological, philosophical, ethical, spiritual and occult implications of the modernist position,
each of these women, excepting the classical scholar Jane Harrison, also wrote fiction. The aesthetic
questions of modernism dovetail into the theoretical arguments of the writers in this thesis, inviting a
different reading of its psychological sub-text and to suggest that where 'stream-of-consciousness' is
stylistically indispensable, the 'oceanic', as counterpart, thematically haunts the modernist aestheti
A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis.
No full textBACKGROUND: Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes. Strategies which include agents able to enhance host cell killing mechanisms could represent an alternative to conventional methods with the potential for host clearance if active against dormant phenotypes. Investigations of agents with potential activity against non-replicating mycobacteria however are restricted due to a need for assays that can assess bacterial viability without having to culture.
RESULTS: This study describes the development and use of a pre16S ribosomal gene RNA/DNA ratio viability assay which is independent of the need for culture, supported by a novel thin layer accelerated mycobacterial colony forming method for determining viability and culturability of MAP in intracellular environments. We describe the use of these tools to demonstrate intracellular killing activity of a novel rhodanine agent (D157070) against the intracellular pathogen Mycobacterium avium subspecies paratuberculosis (MAP) and show that the culturability of MAP decreases relative to its viability on intracellular entry suggesting the induction of a non-culturable phenotype. We further demonstrate that D157070, although having no direct activity against the culturability of extracellular MAP, can bind to cultured MAP cells and has significant influence on the MAP transcriptome, particularly with respect of delta(L )associated genes. D157070 is shown to be taken up by bovine and human cells and able to enhance host cell killing, as measured by significant decreases in both culturability and viability of intracellular MAP.
CONCLUSIONS: This work suggests that pre16srRNA gene ratios represent a viable method for studying MAP viability. In addition, the rhodanine agent D157070 tested is non-toxic and enhances cell killing activity against both growing and latent MAP phenotypes
Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
No full textNeuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
No full textNeuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
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