520,036 research outputs found
Overexpression of Cyclin D1 and C-Myc Gene Products in Human Primary Epithelial Ovarian Cancer
No full textCyclin D1 and c-Myc are key participants in the cell-cycle pathway, in which aberrancies have been associated with malignant transformation. To date, data on the relationship of expression of these proteins and histologic subtype of epithelial ovarian cancer are still scarce and discordant. Immunohistochemical analysis was performed on 12 normal ovaries and 47 cases of serous, mucinous, endometrioid, and clear cell ovarian carcinomas. No abnormal expression of cyclin D1 or c-Myc was demonstrated in any of the 12 normal ovarian specimens. However, compared to normal ovarian tissues, overexpression of cyclin D1 and c-Myc was observed in 42.6% (20/47) and 65.9% (31/47) of tumors examined, respectively. There was no significant difference of overexpression of cyclin D1 or c-Myc gene products between these four histologic subtypes of ovarian adenocarcinomas. This study shows that cyclin D1 and c-Myc are frequently overexpressed in epithelial ovarian carcinomas, but they are not correlated with a particular histologic subtype. Although our preliminary results need to be validated in a larger number of tumors, the abnormal expression of cyclin D 1 and c-Myc in epithelial ovarian cancer reaffirms the notion that they are crucial components in the pathway of tumorigenesis and deserve further study
[Handwritten report by J. C. Watson concerning the shooting of Lee Harvey Oswald #1]
No full textHandwritten report by J. C. Watson regarding officer's duties and witness to the shooting of Lee Harvey Oswald by Jack Ruby. Watson describes his duties, actions, and observations during the transfer of Lee Harvey Oswald from City Hall to the County Jail
[Handwritten report by J. C. Watson concerning the shooting of Lee Harvey Oswald #2]
No full textHandwritten report by J. C. Watson regarding officer's duties and witness to the shooting of Lee Harvey Oswald by Jack Ruby. Watson describes his duties, actions, and observations during the transfer of Lee Harvey Oswald from City Hall to the County Jail
[Report on Officer's Duties by C. N. Dhority, in regards to Lee Harvey Oswald's murder #2]
No full textReport on Officer's duties by C. N. Dhority, in regards to Lee Harvey Oswald's murder. Dhority describes assisting Captain Fritz with the transfer of Oswald and moving his car to the front of the jail office
[Report on Officer's Duties by C. N. Dhority, in regards to Lee Harvey Oswald's murder #1]
No full textReport on Officer's duties by C. N. Dhority, in regards to Lee Harvey Oswald's murder. Dhority describes assisting Captain Fritz with the transfer of Oswald and moving his car to the front of the jail office
[Amnesty Letter] ID153 / Lee, Henry C.
No full textThis letter was written by Henry C. Lee to President Andrew Johnson in response to the President's Amnesty Proclamation of 29 May 1865. The writer indicates his county of residence as Haywood Co., NC and states his occupation as Farmer
Lee, John C. - An inaugural dissertation on dysmenorrhea
No full textHandwritten inaugural dissertation on dysmenorrhoea by John C. Lee, of Georgia.Inaugural dissertation; no. 156
[Report on Officer's Duties by L. C. Graves, in regards to Lee Harvey Oswald's murder #2]
No full textReport on Officer's duties by L. C. Graves, in regards to Lee Harvey Oswald's murder. Graves describes helping other officers in the transfer of Oswald to the County Jail. He states that Jack Ruby sprang forward out of a line of camera men outside the jail office, and fired one round from a pistol into Oswald's stomach
[Report on Officer's Duties by C. W. Brown, in regards to Lee Harvey Oswald's death #1]
No full textReport on Officer's duties by C. W. Brown, in regards to Lee Harvey Oswald's death. Brown states that he was in a car with the driving squad that was transporting Oswald. He heard a gunshot while backing up his car to the jail office
[Report on Officer's Duties by C. W. Brown, in regards to Lee Harvey Oswald's death #2]
No full textReport on Officer's duties by C. W. Brown, in regards to Lee Harvey Oswald's death. Brown states that he was in a car with the driving squad that was transporting Oswald. He heard a gunshot while backing up his car to the jail office
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