2,605 research outputs found

    Terry Underwood

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    Date:1948Terry Underwood arrived in the Northern Territory in 1968 and with her new husband moved to a new home at Riveren. Home consisted of a caravan, a bough shed, camp stove and a tent as the master bedroom. Together they transformed Riveren into a thriving cattle station. Over a span of 30 years she has been involved in many projects which have included: producer/director of plays, talent quests and documentaries, along with appearances on TV and radio. She is also a patron to the Australian Outback Tourism Association and Northern Territory Fashion Awards. In 2005 Underwood was awarded the Medal of the Order of Australia in the General Division in Queen's Birthday 2005 Honours List for "service to the community, particularly through business and in promotional and cattle industry roles". In her autobiography 'In the middle of nowhere' Underwood captures the essence of her life "Riveren has captured our bodies, hearts and spirits. It lies within the heart of Australia. How privileged we are to call it home. Riveren is where I belong. I know it would not have worked anywhere else with anyone else. In the middle of nowhere has become my everywhere." (Underwood, 1998: 276). Source: In the middle of nowhere. Terry Underwood. Moorebank, NSW : Transworld, 1998.NurseAuthorPhotographerCattle Woma

    Teacher and Author Terry Frith

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    Terry Bryant Frith, a former Manatee County teacher, works in her office. Frith, a lifelong Bradenton resident, wrote a book called "Secrets Parents Should Know About Public Schools" which was published by Simon and Schuster

    Roger McDonald, author in the caravan [picture] /

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    (PIC/3034/28); Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic-an14517845-28

    Regulation of Asymmetric Cell Divisions in the Developing Epidermis

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    During development, oriented cell divisions are crucial for correctly organizing and shaping a tissue. Mitotic spindle orientation can be coupled with cell fate decisions to provide cellular diversity through asymmetric cell divisions (ACDs), in which the division of a progenitor cell results in two daughters with different cell fates. Proper tissue morphogenesis relies on the coupling of these two phenomena being highly regulated. The development of the mouse epidermis provides a powerful system in which to study the many levels that regulate ACDs. Within the basal layer of the epidermis, both symmetric and asymmetric cell divisions occur. While symmetric divisions allow for an increase in surface area and progenitor cell number, asymmetric divisions drive the stratification of the epidermis, directly contributing additional cell layers (Lechler and Fuchs 2005; Poulson and Lechler 2010; Williams, Beronja et al. 2011). Utilizing genetic lineage tracing to label individual basal cells I show that individual basal cells can undergo both symmetric and asymmetric divisions. Therefore, the balance of symmetric:asymmetric divisions is provided by the sum of individual cells' choices. In addition, I define two control points for determining a cell's mode of division. First is the expression of the mInscuteable gene, which is sufficient to drive ACDs. However, there is robust control of division orientation as excessive ACDs are prevented by a change in the localization of NuMA, an effector of spindle orientation. Finally, I show that p63, a transcriptional regulator of stratification, does not control either of these processes, rather it controls ACD indirectly by promoting cell polarity. Given the robust control on NuMA localization to prevent excess ACDs, I sought to determine how targeting of NuMA to the cortex is regulated. First, I determined which regions within the protein were necessary and sufficient for cortical localization. NuMA is a large coiled- coil protein that binds many factors important for ACDs, which include but are not limited to: microtubules, 4.1, and LGN. Interestingly, while the LGN binding domain was necessary, it was not sufficient for proper NuMA localization at the cortex. However, a fragment of NuMA containing both the 4.1 and LGN binding domains was able to localize to the cortex. Additionally, the NuMA-binding domain of 4.1 was able to specifically disrupt NuMA localization at the cortex. These data suggested an important role for a NuMA-4.1 interaction at the cortex. While the 4.1 binding domain was not necessary for the cortical localization of NuMA, it was important for the overall stability of NuMA at the cortex. I hypothesize that 4.1 acts to anchor/stabilize NuMA at the cortex to provide resistance against pulling forces on the mitotic spindle to ensure proper spindle orientation.Finally, to determine if post-translational modifications of NuMA could regulate its localization I tested the importance of a conserved Cdk-1 phosphorylation site. Interestingly, a non-phosphorylatable form of NuMA localized predominately to the cortex while the phosphomimetic protein localized strongly to spindle poles. In agreement with these data, use of a CDK-1 inhibitor was able to enhance the cortical localization of NuMA. Unexpectedly, the non-phosphorylatable form of NuMA did not require LGN to localize to the cortex. Additionally, restoration of cortical localization of the phosphomimetic form of NuMA was accomplished by the overexpression of either LGN or 4.1. Thus, phosphorylation of NuMA may alter its overall affinity for the cortex. Overall, my studies highlight two important regulatory mechanisms controlling asymmetric cell division in the epidermis. Additionally, I show a novel role for the interaction between NuMA and 4.1 in providing stability at the cortex. This will ultimately provide a framework for analysis of how external cues control the important choice between asymmetric and symmetric cell divisions.</p

    "Disney is the Tiffany’s and I am the Woolworth's of the business": A critical re-analysis of the business philosophies, production values and studio practices of animator-producer Paul Houlton Terry

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    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Animator-producer Paul Houlton Terry has been portrayed as having little passion for the animation he produced and being more concerned with making a profit than producing entertaining cartoons with high production values. The purpose of the dissertation is to re-evaluate Terry‘s legacy to animated cartooning by analyzing his business philosophies, production values, and studio practices. Application of four psychodynamic factors to the early life and career of Terry, 1887-1929, found that his economic decision making was characterized by: an external locus of control, risk-averse financial behaviour, extreme saving behaviour through precaution, and shrewd money management practices. Based on Terry‘s historical responses to twelve major economic, technological, or institutional forces of change for the period 1929-1955, the psychodynamic factors were found to provide accurate explanations for his studio practices and production decisions. There was no evidence to support the conclusion that three early career disappointments undermined Terry‘s intrinsic motivation to create animated cartoons. Rather, Terry‘s lack of risk taking, external locus of control, tight studio production schedule, desire to compete with neighbour studio Fleischer, difficulty in separating financial rewards from creative processes in animation, and practice of undertaking surveillance measures on staff may have undermined his and his studio‘s creativity. Archival research found Terry to possess strong passions for and to have made significant creative contributions to the field of animation. Biographical research found that Terry retained a stable nucleus of highly talented artists who dedicated a significant portion of their working careers to the studio. An analysis of the cel aesthetics of a random sample of animated cartoons produced during the years 1930-1955 found that Terry created animated cartoons with above average cel aesthetics when compared to the other studios thereby supporting an inference that Terry was motivated to producing quality crafted animation. Further research is suggested into the role psychodynamic factors and economic decision-making play in the film production process and a clarification of Terry‘s legacy to the field of animated cartoons

    Terry White

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    Photograph - A portrait of Dr. Terry White, Executive Member of the Trail North Foundation, Athabasca, Albert

    A Conversation with Terry Tempest Williams

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    Terry Tempest Williams is a conservationist, advocate for free speech, and the author of several books, poetry collections, and essay collections. With a career spanning over forty years, Williams has often been called a “citizen writer” who consistently illuminates how environmental issues are social issues, and ultimately how these issues transform into matters of justice. Her books include Refuge: An Unnatural History of Family & Place, Finding Beauty in a Broken World, When Women Were Birds: Fifty-four Variations on Voice and Williams’ most recent work, The Moon is Behind Us. Williams has received the Robert Marshall Award from The Wilderness Society, the Spirit of the Arctic Award, an International Peace Award, and a Robert Kirsch Award among many other accolades for her writing and activism. She is currently writer-in-residence at the Harvard Divinity School. During this program, Terry Tempest Williams read from her work and gave a brief talk on her writing and its relationship to our current times, following which she participated in a moderated onstage conversation

    New media policies

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    In this book chapter Terry Flew looks at key texts mapping the economical and policy context of managing media companies and the organization of labor and production across the creative industries. Managing Media Work, edited by Mark Deuze, is now out. Information about the book can be found on the SAGE Web site. The Table of Contents is here. &nbsp; Note: the PDF file attached is the author\u27s final cop

    Terry on patrol

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    Author, Terry, on left, on patrol, 1910-1915.Johns, Robert Darwin. & Johns, Darby Richard.Date:191

    Terry Pratchett ist jetzt Ritter

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    <![CDATA[Terry Pratchett ist zum Ritter "befördert" worden â??There are times when phrases such as â??totally astonishedâ?? just donâ??t do the job. I am of course delighted and honoured and, needless to say, flabbergasted.â? Der Schöpfer der Scheibenwelt kennt sich gut in Bibliotheken aus, zu ersehen auch schon an der Person des  Bibliothekars in der Unsichtbaren Universität. Herzlichen Glückwunsch!! btw: Der sympathisch gealterte Robert Plant (Bildstrecke hier) hat ebenfalls diese Auszeichnung erhalten... Related articles by Zemanta Novelist Terry Pratchett knighted in New Year honours list SIR Terry Pratchett Arise, Sir Terry! Discworld Author Terry Pratchett Knighted ]]
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