1,720,969 research outputs found
Deep vein thrombophlebitis of a leg in a young female with heterozygous protein C deficiency taking oral contraceptives.
No full textThe relationship between defective heparin cofactor activities and thrombotic phenomena in AT III abnormalities.
No full textPeculiar rocket profile in the electroimmunoassay of protein-S-deficient plasma: a clue to diagnosis?
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The report of an Italian family with heterozygous protein C deficiency.
No full textAbstract
A heterozygote protein C deficit was found in 4 members of the same family. The propositus is a 40 year old male with a clear thrombotic tendency. This included repeated thrombophlebitis of the right leg, and one episode of pulmonary embolism. Arterial thrombosis was not noted. The anticoagulant therapy undertaken by the patient appears to be of some benefit in the sense that no recurrence of thrombotic manifestations occurred. One brother and two nephews of the propositus, even though asymptomatic showed reduced levels of Protein C both as activity and antigen. The parallel reduction of Protein C activity and antigen points towards a "true" deficit of Protein C. The normal, although reduced, pattern in the crossed immunoelectrophoresis supplies further confirmation to this interpretatio
FACTOR-VIII VONWILLEBRAND-FACTOR ABNORMALITIES DURING L-ASPARAGINASE TREATMENT IN PATIENTS WITH ACUTE LYMPHOBLASTIC-LEUKEMIA
No full textFactor VIII/von Willebrand factor (VIII/vWf) related properties were studied in 10 patients affected by acute lymphoblastic leukemia during L-asparaginase-vincristine-prednisone treatment. These properties remained within the normal range during the period of observation without any difference from the basal values. On the contrary, VIII:C activity was already increased before medication and showed gradual additional elevation during the observation period, reaching a peak 1 week after discontinuation of L-asparaginase administration. Crossed immunoelectrophoresis of vWf, performed weekly in 2 patients during the period of medication, demonstrated a normal pattern before the beginning of treatment, but an apparently faster migrating peak during L-asparaginase therapy, suggesting a qualitative abnormality of vWf. No abnormal bleeding tendency was found in any of the patients
Hereditary heparin cofactor II deficiency and thrombosis: report of six patients belonging to two separate kindreds.
No full textFactor X antigen--factor X activity discrepancy in coumarin treated patients. No relationship with dilution curve.
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