594 research outputs found
Peptide and protein-like hydrogels, synthesis, and applications in biomedicine
No full textPeptide and protein therapies have led to revolutionary changes in the treatment and prevention of disease worldwide, including hypertension, diabetes, infection and inflammatory disorders. This chapter will look at how one of nature’s most important building blocks can be utilised as an advanced hydrogel material with inherent drug delivery and biomaterial properties. Central themes covered include: their synthesis and manufacture at both laboratory and industrial scale; regulatory aspects that inform their clinical translation and the benefits of peptides in the context of medicine and how these may be overcome using peptide-mimetic molecules. The chapter also looks at several important applications for hydrogel systems alongside challenges to their future development and use including within treatment of hormone dysfunction, cancer, as long-acting drug delivery systems and infection
Silk hydrogels for drug and cell delivery
Get PDFSilk has fascinated humans since ancient times; silk fibres have been used in textiles for more than 5,000 years and for many centuries as a suturing material (Lubec, Holbaubek et al. 1993, Omenetto and Kaplan 2010). The remarkable strength and toughness of silk stems from its evolution as a structural engineering material in nature (Vollrath and Porter 2009, Buehler 2013). Silk is a sustainable and ecologically benign biopolymer that can be manufactured using green processes (Vollrath and Porter 2009). Over the past 25 years, we have seen a tremendous development of both bottom-up and top-down approaches for the generation of silk biopolymers
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Hydrogels in wound management
Get PDFOne of the most prevalent applications of hydrogels is wound management. Thanks to their high water content and unique physical properties, hydrogels could potentially resemble biological tissues including human skin. (Peppas et al. 2000, Gupta et al. 2010, Caló & Khutoryanskiy 2014, Jones et al. 2006) There is active interest in the development of new and advanced hydrogel-based products from both an academic and industrial perspective. In fact, hydrogels exhibit many characteristics of the ‘ideal’ wound dressing. These include: the capability of maintaining a moist environment at the wound site allowing gas exchange (moisture vapour transmission), biocompatibility, fast absorption of wound exudate, protection of newly formed or delicate skin and easy and relatively painless dressing removal. (Thomas 1990, Gupta et al. 2010, Vowden & Vowden 2014, Boateng & Catanzano 2015) In this Chapter we will provide the reader with an overview of the most recent hydrogel materials designed for wound management
Ultrashort self-assembling peptidomimetic nanomaterials target resistant pathogenic infections
No full textThe impending and increasing threat of antimicrobial resistance has led to a greater focus into developing alternative therapies as substitutes for traditional antibiotics for the treatment of multi-drug resistant infections.1 Our group has developed a library of short, cost-effective, diphenylalanine-based peptides (X1-FF-X2) which selective eradicate (viability reduced >90% in 24 hours) the most resistant biofilm forms of a range of Gram-positive and negative pathogens including: methicillin resistant and sensitive Staphyloccoccus aureus and Staphyloccoccus epidermidis; Pseudomonas aeruginosa, Proteus mirabilis and Escherichia coli. They demonstrate a reduced cell cytotoxic profile (NCTC929 murine fibroblast) and limited haemolysis.2 Our molecules have the ability respond to subtle changes in pH, associated with bacterial infection, self-assembling to form β-sheet secondary structures and supramolecular hydrogels at low concentrations (~0.5%w/v). Conjugation of variety of aromatic-based drugs at the X1 position, including non-steroidal anti-inflammatories (NSAIDs), confer further pharmacological properties to the peptide motif enhancing their therapeutic potential. In vivo studies using waxworms (Galleria mellonella) provide promising preliminary results demonstrating the low toxicity and high antimicrobial activity of these low molecular weight gelators in animal models. This work shows biofunctional peptide-based nanomaterials hold great promise for future translation to patients as antimicrobial drug delivery and biomaterial platforms.3 [1] G. Laverty, S.P. Gorman and B.F. Gilmore. Int.J.Mol.Sci. 2011, 12, 6566-6596. [2] G. Laverty, A.P. McCloskey, B.F. Gilmore, D.S. Jones, J Zhou, B Xu. Biomacromolecules. 2014, 15, 9, 3429-3439. [3] A.P. McCloskey, B.F. Gilmore and G.Laverty. Pathogens. 2014, 3, 791-821
‐Peptide Hydrogels as a Long‐Acting Injectable Platform for Systemic Delivery of HIV/AIDS Drugs (Adv. Healthcare Mater. 18/2023)
No full textGraphical AbstractHIV/AIDS DrugsIn article 2203198, Garry Laverty and co-workers develop a long-acting injectable drug delivery implant composed of a short peptide sequence attached to the HIV/AIDS drug zidovudine. Upon injection, this aqueous solution-based formulation rapidly forms a drug-releasing hydrogel implant in response to phosphatase enzymes present within the skin space. Clinically relevant concentrations of zidovudine were delivered to rat models for 35 days, outlining the promise of this platform to improve patient adherence to HIV/AIDS drugs
Garry Neill Kennedy: Printed Matter / Imprimés 1971-2009, by Peter Trepanier [book review]
Get PDFThe article reviews the book "Garry Neill Kennedy: Printed Matter/Imprimés 1971-2009" by Peter Trepanier, part of the "Occasional Papers" book series.Peer reviewedreview article
The participation of women employed in traditionally male dominated occupations including plumbing: 1975–2013
No full textAuthor Garry Cruickshank investigates the gender gap in New Zealand’s plumbing profession. Having established that the proportion of female plumbers is almost unchanged since 1975, Cruickshank compares this information with data gathered from other trades and exposes the widespread nature of this trend across traditionally male dominated industries. The author reflects on what could to be done to alter this situation
Crimson clover
No full textprepared by Dr. Don Ball (Extension Agronomist/Alumni Professor, Auburn University) and Dr. Garry Lacefield (Extension Agronomist/Professor, University of Kentucky).Title from PDF front panel (viewed on February 5, 2020).Covers OCLC #1139336431, OCLC #1139347191Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
Putting clovers in grass pastures
No full textauthors: Dr. Garry Lacefield, Professor Emeritus, University of Kentucky, Dr. Don Ball, Professor Emeritus, Auburn University.Title from PDF front panel (viewed on February 5, 2020).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
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