105 research outputs found
Author Correction: COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials
No full textIn the original version of this Perspective, the name of the author Giuseppe Curigliano was incorrectly written as Guiseppe Curigiliano. The affiliations have been corrected in the HTML and PDF versions of the manuscrip
Bayesian multiple deferred sampling planBMDS (0,1) with weighted poisson model using Golub’s minimum risks method
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Author Correction: EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment (Nature Reviews Clinical Oncology, (2022), 19, 1, (51-69), 10.1038/s41571-021-00558-1)
No full textLightweight Knee Bolster Assembly for Belted and Unbelted Occupant Restraint in a Frontal Crash
No full textAutomated denoised ultrasound carotid artery image segmentation using curvelet threshold decomposition
No full textOptimization and Development of Magnetically Triggered Letrozole Nanoliposomes for Breast Cancer Targeting
No full textBackground: Breast cancer is one of the most frequently diagnosed cancers and is the leading cause of death among women worldwide [...
Novel Simulator for Wireline Mini-Fracture Testing
No full textWireline Mini-Fracture testing jobs consist of a short duration, small volume fracturing operation inside an open-hole borehole, where a certain amount of fluid is injected into the formation at constant rate using a Wireline Modular conveyed tool as a source of hydraulic power to pressurize the wellbore. The tool is configured with an inflatable straddle packer and an internal pump, which inflate/deflates the packers and supplies pressure to the formation until a hydraulic fracture is induced. This procedure is used to determine in–situ formation breakdown and closure pressure also known as minimum horizontal closure pressure. This provides vital information regarding hydraulic fracture design, water and gas injection management, fault re-activation, wellbore stability, sand production, rock mechanical properties, casing string design, cap and base rock integrity and gas storage design. Geomechanical and operational parameters such as, elastic properties, poro-elasticity, rock strength, formation pore pressure, far field horizontal stress, permeability/porosity distributions, borehole fluid properties among others, influences the performance of the Mini-Frac Jobs. In many cases poor understanding of the reservoir response to the fracture process, caused that the hydraulic fracture did not propagate deep into the formation. In other cases the pressure applied to the formation might be insufficient to break down the formation, leading to unsatisfactory application of the Mini-Fracture technique in the process. The objective of this thesis is to develop a Mini-Facture application simulator that uses the geomechanical and operational parameters that control the performance of a Mini-Fracture job and estimate the possibility of the occurrence of a tensile failure in the formation. The simulator is then validated by comparing its output with the results of stress test done in the field. With this simulator petrotechnical professionals and field engineers will have a platform that simulates the pressure responses and fracture initialization during Mini-Frac treatments, incorporating all the variables affecting a Wireline Mini-Fracture job, helping the design engineer to make key decisions about the ultimate or required fracture plan. Furthermore the simulator will reduce the uncertainties that limit the reliability of the Wireline Mini-Fracture treatment by allowing the selection of appropriate tool configuration based on the job objectives and the geological environmental conditions. Finally this project demonstrates that combining the appropriate constitutive relations that reflect the coupling among the tool operational performance with wellbore flow, reservoir and geomechanics modelling a Mini-Fracture simulator can be developed.Petroleum EngineeringGeoscience & EngineeringCivil Engineering and Geoscience
Synthesis and Preliminary Investigation of Metal Nanoparticles from the Stem Extract of Bacopa sp. for the Treatment of Lung Cancer
No full textLung cancer is the third most common cancer in women and the most common cancer in males. Chemotherapy, allopathy, hormone therapy, radiation therapy, surgery, immune system, and targeted therapies are frequently used to treat lung cancer. These medications induce other diseases and have a variety of negative effects. Thus, we used a different strategy and sought to treat lung cancer with medicinal herbs. We selected the perennial creeping herb Bacopa monnieri, which belongs to the Scrophulariaceae family, among other medicinal herbs. It contains several active phytoconstituents, including sterols, alkaloids, flavanoids, terpenoids, and saponins. The primary component with anti-lung cancer efficacy is phytosterol, according to the components. According to the phytochemical investigation, this plant contained it. The literature review indicates that the problem is lessened by nanoparticle production. Thus, the novelty of our work is the manufacture of zinc oxide nanoparticles for the treatment of lung cancer using BM stem extracts. Researchers have been interested in ZnO material because of its huge band gap (3.37 eV) with n-type semi-conductivity and high excitonic binding energy (60 meV) with regards to the different semiconductor nanomaterials, such as TiO2, SnO2, GaN, CuO, GaAs, Si, and ZnO. Zinc oxide in bulk is economical and can be used for many different industrial processes, such as the creation of nanoparticles. Zinc acetate serves as the precursor and stem extract serves as the reducing agent in the synthesis. The absorbance peak between 300 and 400 nm in UV spectroscopy was used to characterize the ZnO nanoparticles that were produced from hydromethanolic BM stem extract. In later research, lung cancer treatment might be considered. Given that lung (A549) cell lines will be treated with phytosterol-containing hydromethanolic BM stem extract in the form of ZnO nanoparticles, which will cause cell death by reducing cell proliferation, DNA damage and apoptosis may occur
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