84 research outputs found
Prognostic significance of Bcl-2 expression in primary cutaneous B-cell lymphoma: a reappraisal
No full textINTRODUCTION: Bcl-2 family protein plays an important role in apoptosis and its overexpression is protects neoplastic cell from apoptotic stimuli. Cutaneous B-cell lymphoma are rare non-Hodgkin lymphomas and can be classified in primary forms, featuring an exclusive skin-involvement at diagnosis, and cutaneous spread of a nodal disease. Such a distinction is not trivial, owing to different prognosis (indolent vs. aggressive) and therapeutic management.EVIDENCE ACQUISITION: Bcl-2 expression at immunohistochemistry can be crucial in differential diagnosis between cutaneous and systemic disease, as well as between the different primary cutaneous forms.EVIDENCE SYNTHESIS: In the last few years, an animated debate on the prognostic role of BCL-2 overexpression at molecular analysis have been developed in cutaneous B-cell lymphoma.CONCLUSIONS: Bcl-2 expression have a diagnostic role more than prognostic in primary cutaneous B-cell lymphomas
BCL-2 Expression in Primary Cutaneous Follicle Center B-Cell Lymphoma and Its Prognostic Role
No full textN/A - OPINION ARTICL
L’Health Literacy come strumento al servizio della sanità pubblica: la misurazione dei livelli e delle associazioni dell’Health Literacy in un campione di popolazione generale e la validazione di nuovi strumenti di misura
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Comment on Maglione et al. Changes in Respiratory Viruses’ Activity in Children During the COVID-19 Pandemic: A Systematic Review. J. Clin. Med. 2025, 14, 1387
No full textWe read with great interest the recently published systematic review by Maglione et al [...
Worsening Renal Function in Patients Hospitalized with Acute Heart Failure: Risk Factors and Prognostic Significances
No full textObjectives. To determine the prevalence, the clinical predictors, and the prognostic significances of Worsening Renal Function (WRF) in hospitalized patients with Acute Heart Failure (AHF). Methods. 394 consecutively hospitalized patients with AHF were evaluated. WRF was defined as an increase in serum creatinine of ≥0.3 mg/dL from baseline to discharge. Results. Nearly 11% of patients developed WRF. The independent predictors of WRF analyzed with a multivariable logistic regression were history of chronic kidney disease (=.047), age >75 years (=.049), and admission heart rates ≥100 bpm (=.004). Mortality or rehospitalization rates at 1 month, 6 months, and 1year were not significantly different between patients with WRF and those without WRF. Conclusion. Different clinical predictors at hospital admission can be used to identify patients at increased risk for developing WRF. Patients with WRF compared with those without WRF experienced no significant differences in hospital length of stay, mortality, or rehospitalization rates
Optimality Theory and the Minimalist Program
No full textIn this paper I argue that an OT-approach to grammar is actually essential to minimalist investigations, because it dramatically widens the set of linguistic properties potentially reducible to interface conditions while at the same time dispensing with interface-external language specific provisos. The discussion will hopefully also dispel some common misconceptions about OT.The definitive version of this paper is published in Linguistics in Potsdam 25 (2006).Samek-Lodovici, V. (2006). Optimality Theory and the Minimalist Program. In H. Broekhuis & R. Vogel (Eds), Linguistics in Potsdam 25. Optimality Theory and Minimalism: A possible Convergence? Potsdam : Universitätsverlag PotsdamISBN: 9783939469544 (published book
On the ungrammaticality of remnant movement in the derivation of Greenberg's universal 20
No full textWe propose an OT analysis that derives the crosslinguistic typology described in Cinque (2005) concerning the grammatical and ungrammatical linear orders involving a demonstrative, a numeral, an adjective, and a noun. We show that the interaction of four simple constraints, respectively requiring leftward alignment of demonstratives, numerals, adjectives, and nouns, is sufficient to derive all the attested orders. The analysis also explains why, as Cinque pointed out, all unattested orders involve remnant movement. We show that remnant movement of the type considered in Cinque (2005) inevitably produces inherently suboptimal alignment configurations, which, in turn, are harmonically bounded by their remnant-movement-free counterparts. This result allows us to avoid stipulating conditions aimed at blocking remnant movement as proposed in Cinque (2005). Any movement is potentially possible, remnant movement included, but the resulting structures only surface as grammatical when instantiating the best possible alignment configuration for at least one constraint ranking. Indeed, we show that even remnant movement becomes grammatical when it determines optimal alignment. Finally, we show how Cinque’s original analysis closely records the structural derivations of the attested orders into the parametric values necessary to distinguish the attested languages from each other. In contrast, the proposed OT analysis need not stipulate the structural properties of any attested structure, letting them all emerge from the interaction of the proposed constraints.The publisher of the journal in which this article appears does not permit the archiving of this or any other version of the article in the Rutgers Optimality Archive. The authorized version is available here: http://www.jstor.org/stable/2301192
Galaxy Clusters in MOND: from Aether Theories to FEM in FEniCS
No full textModified Newtonian Dynamics (MOND) can account for a variety of phenomena on galactic scales without the need for dark matter, but it cannot fully explain the mass contained in galaxy clusters. We explore two possible solutions to this problem: relativistic extensions of MOND, and FEM simulations of the apparent matter distribution in clusters, utilising the non-linear AQUAL formulation to analyse non spherically symmetric systems. We consider Covariant Emergent Gravity, and we show that the theory is inconsistent with the original formulation of Emergent Gravity. Moreover, we show that either the theory is incompatible with observations, or it presents grave theoretical difficulties. We then suggest that a covariant formulation of EG can be obtained through a Generalised Einstein Aether (GEA) theory, which is capable of retrieving the MOND PDE, and is, at the same time, consistent with observational constraints. Regarding the FEM simulations of the apparent matter distribution in galaxy clusters, we construct a sample of 15 clusters from the catalogs of Reiprich and Abell for the baryonic mass distribution present in galaxy clusters. We choose FEM for its ability to treat the combination of continuous and discrete mass distributions without the need for smoothing. This is necessary, as in MOND we cannot apply the principle of superposition or the weak lensing formalism. We then utilise the FeniCS software package to study the properties of these clusters. We simulate each cluster with elements up to degree 3, thanks to a speedup by a factor of ∼ 100 obtained by the use of local mesh refinement for the serial case. In addition, we run the code in parallel on a single-threaded 8-core CPU, achieving near optimal weak scaling for the regime of interest. For the mass distribution in the galaxy clusters, we analyse the distribution of baryons, Phantom Dark Matter (PDM) and apparent mass both close to the core and around each galaxy. We find that the PDM tends to clump around the galaxies, regardless of the gas to galaxy mass ratio. Moreover, we show that both the apparent mass and the PDM can exhibit negative masses as predicted by Milgrom. Our observations on the density of PDM around the galaxies match recent observations of small scale weak lensing. In addition, our results for negative mass distributions provide an opportunity to test a prediction of MOND that can never be replicated in the dark-matter paradigm, and shed light on the properties of non-spherically symmetric mass distributions, that have, up to now, not been studied in the literature for the fully non-linear case.Double MSc: Applied Physics - Computer EngineeringComputer EngineeringApplied Physic
The Prevalence of Several Risky Driving Behaviors and Associated Crash Risk in Adolescent: A Population-Based Study of Tuscany Region
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