1,720,981 research outputs found
The s.c. 'hairy polyp' or 'dermoid' of the nasopharynx. (An unusual observation in older age).
No full textA case of 'hairy polyp' or 'dermoid' of the nasopharynx in a 71-year-old man is described. This tumor-like condition is usually discovered at birth or during the first years of life. The oldest patient previously recorded in the literature was a 66-year-old man. The occurrence of such masses in older patients suggests that the condition is a malformation and not a neoplasm
TTF-1 Expression in Nephroblastoma
No full textThe unexpected observation of nuclear immunoreactivity for thyroid transcription factor-1 (TTF-1) associated with an apparent lack of nuclear immunoreactivity for Wilms tumor-protein (WT1) in the pulmonary metastasis of a morphologically typical case of nephroblastoma affecting a 6.5-year-old male prompted us to examine the expression of these 2 markers (and CD56) in a series of 48 nephroblastomas, 5 adult metanephric adenomas, and 1 pediatric cystic nephroma. TTF-1 was found to be positive in 8 of 48 (16.6%) nephroblastomas and negative in all 5 metanephric adenomas. WT1 was positive in 43 of 48 (89.6%) nephroblastomas and 4 of 5 (80.0%) metanephric adenomas. CD56 was positive in 45 of 47 cases that were so tested (95.74%), but negative in all metanephric adenomas. The single cystic nephroma was TTF-1-negative, WT1-negative, and CD56-positive. The finding of TTF-1 expression in one sixth of nephroblastomas constitutes a potential source of misdiagnosis. The biologic significance of this surprising finding is unclear. It may reflect the embryonal nature of these tumors and may conceivably result-directly or indirectly-in interference with the transcriptional control of target genes and other molecular events in the pathway leading to the development of nephroblastoma
“Massive intestinal perforating ischemia in a patient with systemic lupus erythematosus”
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INFILTRATING MYOEPITHELIOMA OF THE BREAST
No full textTumors exclusively composed of myoepithelial cells are extremely uncommon in the breast. We report such a tumor in a 25-year-old white woman. Clinical and ultrasonographic findings suggested a small benign lesion of the breast. Nodulectomy performed for intraoperative diagnosis found a malignant spindle cell tumor. Consequently, a quadrantectomy with axillary lymphadenectomy was carried out. Routine stains suggested a tumor of myoepithelial origin that infiltrated the fat tissue; immunocytochemical stains demonstrated strong cytoplasmic reactivity for actin, cytokeratin, S-100 protein, and vimentin. Glial fibrillary acidic protein (GFAP) was detectable only in scattered tumor cells. Examination of the resected breast tissue and lymph nodes did not reveal additional tumor foci. Due to the evidence of infiltrative growth in this case and to the uncertain prognosis for breast myoepitheliomas, we support the previously proposed term ''infiltrating myoepithelioma'' for this rare tumor. We also suggest that immunocytochemistry should be mandatory in every spindle cell tumor of the breast because this morphological pattern is shared by several tumors with different biological behaviors
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