1,701 research outputs found
Macrolides for chronic asthma
No full textBACKGROUND: Asthma is a chronic disease of the airways in which inflammation of the respiratory mucosa plays a crucial role. The mechanisms responsible for the maintaining of this inflammatory response are only partially known and there is evidence that a role could be paid by chronic infection by intracellular pathogens (such as Chlamydia pneumoniae). Macrolides are antibiotics with both antimicrobic and antiinflammatory activities and thus their use in asthmatic patients could lead to reduction of the airways inflammation and therefore improvement of symptoms and pulmonary function.OBJECTIVES: To determine whether macrolides are effective in the management of patients with chronic asthma.SEARCH STRATEGY: We searched the Cochrane Airways Group Specialised Register of trials up to May 2004. This was also supplemented by manually searching bibliographies of previously published reviews, conference proceedings, and contacting study authors. All languages were included in the initial search.SELECTION CRITERIA: Randomised, controlled clinical trials involving both children and adult patients with chronic asthma treated with macrolides for more than 4 weeks, versus placebo.DATA COLLECTION AND ANALYSIS: Two reviewers independently examined all identified articles. The full text of any potentially relevant article was reviewed independently by two reviewers.MAIN RESULTS: Seven studies recruiting a total of 416 participants met the inclusion criteria. The quality of reporting of study methodology was generally low. We assembled findings from studies comparing macrolide treatment for at least 4 weeks in adult and pediatric patients treated for chronic asthma. Four studies showed a positive effect on symptoms of macrolides in different types of asthmatic patients. There were limited data available for meta-analysis. There was no significant difference in FEV1 for either parallel or crossover trials. However, there were significant differences in eosinophilic inflammation and symptoms. One large parallel group trial reported significant differences in peak flow but these differences abated within six months of treatment.AUTHORS' CONCLUSIONS: Considering the small number of patients studied, there is insufficient evidence to support or to refute the use of macrolides in patients with chronic asthma. Further studies are needed in particular to clarify the potential role of macrolides in some subgroups of asthmatics such as those with evidence of chronic bacterial infection
T.J. Stiles: “The Commodore’s Patriotism: Cornelius Vanderbilt’s Path to the Founding of Vanderbilt University”
No full textIncludes descriptive metadata provided by producer in MP4 file: "Chancellor's Lecture Series - Videos - T.J. Stiles: 'The Commodore’s Patriotism: Cornelius Vanderbilt’s Path to the Founding of Vanderbilt University'." By Vanderbilt University. T.J. Stiles, Pulitzer Prize-winning author and historian, speaks Sept. 29, 2010 as part of the Chancellor's Lecture Series. Stiles wrote the 2009 biography The First Tycoon: The Epic Life of Cornelius Vanderbilt. Chancellor Nicholas Zeppos introduces Stiles. Stiles takes questions after his lecture
Cwbr Author Interview: Custer\u27s Trials: A Life On The Frontier Of A New America
No full textInterview with T.J. Stiles, author of Custer\u27s Trials: A Life on the Frontier of a New America Interviewed by Tom Barber
Civil War Book Review (CWBR): The Civil War Book Review is pleased to speak with T.J. Stiles, winner of multiple awards for biography and author of Jesse James: Last Rebel of the Civil War and The First Tycoon: The Epic Life of Cornelius Vanderbilt. Today we get to discuss his most recent work Custer\u27s Trials: A Life on the Frontier of a New America. Mr. Stiles, thank you for joining us today. T.J. Stiles: Thanks very much for interviewing me...
A framework to describe intervention implementation (design, delivery, uptake, and context) in systematic reviews
No full textRapid response to Hoffmann, T.C., Oxman, A.D., Ioannidis, J.P.A., Moher, D., Lasserson, T.J., Tovey, D.I., Stein, K., Sutcliffe, K., Ravaud, P., Altman, D. G., Perera, R., Glasziou, P., (20 July 2017). Enhancing the usability of systematic reviews by improving the consideration and description of interventions; BM
A framework to describe intervention implementation (design, delivery, uptake, and context) in systematic reviews
No full textRapid response to Hoffmann, T.C., Oxman, A.D., Ioannidis, J.P.A., Moher, D., Lasserson, T.J., Tovey, D.I., Stein, K., Sutcliffe, K., Ravaud, P., Altman, D. G., Perera, R., Glasziou, P., (20 July 2017). Enhancing the usability of systematic reviews by improving the consideration and description of interventions; BM
Flow patterns around longitudinal training dams
No full textWith the intention to reduce the negative effects of ongoing bed erosion, as well as to improve several other river functions such as protection against floods, provision of safe and efficient navigation and ecology, a ‘pilot project longitudinal training dams’ was initiated. The training dams have recently been implemented in the Waal between Tiel and Sind Andries. In this project, river groynes have been completely removed and replaced by dams that lie parallel to the river bank. With help of the longitudinal training dams, a two-channel river system is created in which the river is divided into a main and side channel. The dams are placed in a continuous manner with openings in between that are relatively small compared to the dam length. At the beginning and end of the dam an inlet and outlet region is situated, as shown in Fig. 1. The combination of inlet and openings allows for water and sediment to be divided between the main and the side channel. Both inlet and openings are constructed with the help of a porous rock-layer. The crest heights can be altered by adding or removing stones. This is expected to influence the amount of water and sediment entering the side channel and can therefore be used as a regulation tool. A.J.F. Hoitink, T.V. de Ruijsscher, T.J. Geertsema, B. Makaske, J. Wallinga, J.H.J. Candel, J. Poelman (Eds.) NCR days 2017, Febr. 1-3, 2017. Book of abstracts, NCR publication 41-2017.Rivers, Ports, Waterways and Dredging EngineeringHydraulic Structures and Flood RiskEnvironmental Fluid Mechanic
Seismic interferometry as a tool for improved imaging of the heterogeneities in the body of a landfill
No full textAccepted Author ManuscriptGeo-engineeringApplied Geophysics and Petrophysic
On the dynamics of hydraulic lines supplying servosystems
No full textMechanical, Maritime and Materials Engineerin
Das hydrostatische Keilspaltlager: Berechnung und Anwendung bei Hydrozylindern
No full textMechanical, Maritime and Materials Engineerin
Azomethine-based Donor Materials for Organic Solar Cells
No full textSolution processable organic photovoltaics (OPVs) are attracting much attention because of their anticipated advantages such as low cost, flexibility, lightweight, and the potential to be produced on a large scale. The photoactive layer of OPVs consists of a blend of an electron donating and an electron accepting material. Over the last 20 years, a plethora of (record breaking) electron?donating materials have been reported, which are mostly synthesized via transition metal mediated aryl?aryl coupling reactions. These chemistries, however, make use of expensive metal catalysts, inert reaction conditions and require time?consuming product purification steps. In order to offer a more economic route towards OPVs we have explored novel conjugated azomethine?based (–N=CH–) donor materials and the initial results are presented in this thesis. The azomethine bond is isoelectronic to the vinyl bond (–CH=CH–) and displays similar optoelectronic and thermal properties. In addition, azomethines offer significant advantages over vinylenes as they can be prepared using Schiff base condensation chemistry under near ambient reaction conditions. Expensive catalysts are not required and water is the only by?product. The main objective of this research is to explore the use of azomethine?based donor materials in bulk heterojunction solar cells. The design and synthesis of azomethine?based polymers, (hyper?branched) oligomers, small?molecules (both linear and star?shaped) and their performance in photovoltaic devices will be presented in this thesis.Aerospace Structures and MaterialsAerospace Engineerin
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