6,316 research outputs found
Ana Ra Bradshaw
No full textThe Larson Studio Collection contains portraits and landscape photographs from Thomas Larson and his son O. Blaine Larson, who operated the Larson Studio in Provo, Utah County, Utah
Multicenter versus single center approach to rare diseases: the model of systemic light chain amyloidosis
No full textBACKGROUND: Early diagnosis and supportive therapy are important in primary systemic amyloidosis (AL). In 1986, a national network was started in Italy to increase the awareness of medical professionals, achieve early diagnoses, and provide locally qualified care. We compared the AL patient population observed at a referral center, Mayo Clinic, with that recruited through the Italian network.
METHODS: All the patients diagnosed with AL between 1988 and 1998 at Mayo Clinic or in any of the centers of the Italian Amyloidosis Study Group were included.
FINDINGS: The median survival of Italian patients was 30 months versus 12 months in the Mayo cohort (Por=2 organs involved, and treatment with alkylating agents independently predicted survival. This study shows that AL patient populations may differ significantly between centers according to their accrual systems, with possible impact on treatment trials
Rayleigh number dependence of the Archimedes number dependent large-scale flow structure formation in mixed convection
No full textWe report on experimental investigations of large-scale flow structure formation in mixed convection. We characterize the flow field by measuring the velocity fields within a rectangular model room using 2D2C PIV. The control parameters are the Reynolds number Re, the Rayleigh number Ra and the Prandtl number Pr. All parameters are linked through the Archimedes number Ar. In 6.4x10-2 ≤ Ar ≤ 1.39x101, 4.2x103 ≤ Re ≤ 6.35x104 and Ra = 3.1x107, Ra = 1.8x108 and Pr = 0.713 we found flow 3 different flow structures. While keeping Ra and Pr constant and varying Ar through Re variations, we found an Ar dependence of the largescale flow structure formation within 6.4x10-2 ≤ Ar ≤ 1.39x101. Furthermore, we found a Ra dependence of the structure formation, which shifts the transition points between the structures to higher Archimedes numbers and reduces the mean velocities within the investigated domain
Reynolds numbers near the ultimate state of turbulent Rayleigh-Bénard convection
No full textWe report on measurements of the mean-flow Reynolds number ReU and the rms fluctuation Reynolds number ReV in turbulent Rayleigh-Bénard convection as a function of the Rayleigh number Ra for 4 x 1011 < Ra < 2 1014 and Pr ' 0:8. Both can be described by the same power law with an effective exponent = 0:44, in agreement with predictions for ReU but in disagreement with predictions for ReV
Logarithmic variance profiles and the corresponding f-1 spectra of temperature fluctuations in turbulent Rayleigh-Bénard convection
No full textWe report experimental results for the temperature variance 2(z) and the corresponding frequency spectra P(f) in turbulent Rayleigh-Bénard convection (RBC) in a cylindrical sample of aspect ratioT= D/L = 1:00 (D = 1:12 m is the diameter and L = 1:12 m the height). The measurements were conducted in the Rayleigh-number range 1011 < Ra < 1:35 1014 and Pr ' 0:8. For Ra = 1:35x1014, 2(z) could be described well by a logarithmic dependence on the vertical position z in a range of z 1 < z < z 2 with z 1 ' 70 and z 2 = 0:1L. Here L=(2Nu) is the thickness of a thin thermal sublayer adjacent to the horizontal plate where the heat flux (denoted by the Nusselt number Nu) is carried mostly by thermal diffusion. In the log layer, we found that the temperature spectra had a significant frequency range over which P(f) f with close to 1. As Ra decreased, increased so that the log layer became thinner. At Ra = 2:05 1011, z 2 < z 1 and therefore there was no range for a log layer. Correspondingly, the temperature spectrum near the horizontal plate did not have the f1 scaling form either
Role of retinoic acid degradation in the maturation of inhibitory neurons in the mouse prefrontal cortex
No full textThe purpose of this study was to determine how retinoic acid (RA) signaling affects the maturation of paravalbumin (PV) interneurons in the postnatal prefrontal cortex (PFC). RA plays an important role in early development of the brain and abnormal RA signaling has been associated with schizophrenia, depression and bipolar disorders. Due to the important role RA plays in the brain, the Nakagawa Lab has been studying the roles RA signaling plays in the development of interneurons in the PFC, which are important regulators of excitation-inhibition balance and synchronous firing which forms the basis of our cognition and emotion. We have found that in mice that are deficient of the Cyp26b1 gene, which encodes a RA-degrading enzyme, the number of a subtype of interneurons, called PV interneurons, is increased in postnatal PFC but there is a non-significant difference in survival, indicating that in normal brains RA may promote the maturation of PV interneurons. The goal of my research project is to determine how PV maturation differs in mice with excessive RA signaling, i.e., Cyp26b1 mutant mice. An increase in the number of PV neurons surrounded by perineuronal nets will indicate accelerated maturation. It’s been shown that the number of cells that express PV mRNA is increased in mutant mice at P14 and P21 and the protein is also increased at P14 in the mutants. Therefore, I first focused on these stages and compared the number of PV neurons and perineuronal net positive cells between the Cyp26b1 knockout mice and control littermates.This research was supported by the Undergraduate Research Opportunities Program (UROP).Larson, Abigail K. (2018). Role of retinoic acid degradation in the maturation of inhibitory neurons in the mouse prefrontal cortex. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/195691
Lagrangian Raylaigh-Bénard convection
No full textUsing passive tracers as sensors, we obtain Lagrangian measurements of tracers position, velocity and temperature in Rayleigh-Bénard convection at Ra=10^7-10^9. We report on statistics of temperature, velocity, and heat transport (Nusselt number). We observe that the Nusselt number is characterized by a largely intermittent behavior, likely due to the interaction of temperature with turbulent velocity fluctuations
Photochemical behavior of some p-styryistilbenes and related compounds: Spectral properties and photoisomerization in solution and in solid state
No full textAuthor Posting. © The Authors (2006) This is the author's version of the work. It is posted here for personal use, not for redistribution. The definitive version was published in PHOTOCHEMISTRY AND PHOTOBIOLOGY, 82(6): 1645-1650. https://doi.org/10.1562/2006-01-17-RA-780ArticlePhotochemistry and Photobiology. 82(6): 1645-1650 (2006)journal articl
Aspect-ratio dependence of the transition to the ultimate state of turbulent Rayleigh-Bénard convection
No full textWe report on measurements of the ultimate-state transition in turbulent Rayleigh-B\'enard convection obtained in a large facility known as the ``Uboot of G\"ottingen" and using pressurized sulfur hexafluoride as the convecting fluid. We found that the transition occurs over a range of which becomes more narrow as increases, ranging from which is at most weakly dependent on and close to to which varies from about for to about for
- …
