6,781 research outputs found
Impact of low anterior resection syndrome (LARS) on the quality of life and treatment options of LARS : a cross sectional study
No full textPurpose: The purpose of this study was to assess the relationship between the low anterior resection syndrome (LARS) and quality of life (QOL). Furthermore, in patients with major LARS, therapeutic management options were explored.
Methods: A cohort of surviving patients, who underwent a low anterior resection for rectal cancer after long course of radiochemotherapy, were identified. These patients were treated in Ghent University Hospital between 2006 and 2016. QOL was assessed using the European Organization for Research and Treatment of Cancer Quality Of Life questionnaire-C30 and the bowel function using the LARS-score. The relationship between LARS and QOL was analysed. Patients with major LARS (>= 30 points) were contacted to explore their therapeutic management of LARS.
Results: 69% of the participants had major LARS. QOL was closely associated with LARS. Significant differences were found between those with and without LARS in the global health status (p < 0.001) and in the following functional scales: physical (p < 0.001), role (p < 0.001), cognitive (p = 0.04) and social (p < 0.001). Patients with major LARS experienced more diarrhea (p < 0.001), fatigue (p = 0.002), insomnia (p < 0.001) and pain (p = 0.02), compared to patient with no/minor LARS. Most patients tried dietary regimens (71%), medication (71%) and incontinence material (63.8%) in an attempt to manage their LARS and found some of them useful. The level of the anastomosis (low) was a significant risk factor for major LARS (p=0.03).
Conclusion: More than half of the patients in this cohort still suffered from major LARS. Patients confronted with major LARS had a lower QOL than patients with no/minor LARS. Currently, there is no gold standard for the management of LARS. Patients manage it through trial and error
Axima sidi Arias-Penna, Pape & Krogmann 2014, sp. n.
No full text<i>Axima sidi</i> Arias-Penna, Pape & Krogmann, sp. n. <p>(Figs 1–7, 9)</p> <p> <b>Type material.</b> Holotype female: Colombia, Amazonas, PNN Amacayacu, San Martín, 3º46'S 70º18'W 150 m, sweepnet, 01–10.iii.2004, T. Pape & D. Arias leg. M.4327, IAvH-80813. The holotype is deposited in Instituto de Investigación en Recursos Biológicos Alexander von Humboldt (IAvH), Villa de Leyva, Boyacá, Colombia.</p> <p> <b>Diagnosis.</b> Median mesoscutal carina (Figs 2, 7) distinctly raised, laterally flanked by rows of piliferous foveae. Mesoscutellar process distinctly higher than level of mesoscutum, dorsally rounded. Metasomal terga without distinct white setation (Figs 1, 9), Mt5 bare, Mt6 with few scattered setae (Fig. 9).</p> <p> <b>Description.</b> Body color (Figs 1–7, 9). Body generally brown with ventral and lateral portions of head (Figs 5, 6), mesosoma (Figs 1, 2, 7) and metasoma (Figs 1, 9) yellowish-brown. Legs yellowish brown (Fig. 1). Fore and hind wings hyaline except region immediately below submarginal vein very slightly infumate. Body length: 5.90 mm, head plus mesosoma: 2.35 mm.</p> <p>Head (Figs 1, 2, 5–7). Head punctuate, densely covered with white setae (Figs 5, 6), though less distinct, shorter and thinner, dorsally (Fig. 7). Antenna 10-segmented (Fig. 3). Length of antennal segments (in mm): scape: 0.45, pedicel: 0.06, F1 (anellus): 0.02, F2: 0.27, F3: 0.22, F4: 0.22, F5: 0.20, F6: 0.20, F7: 0.17, clava: 0.32. F2–F6 densely covered with long setae and shorter longitudinal sensilla (Fig. 3). Longitudinal sensilla arranged in multiple irregular rows (number of rows depending on length of flagellomere). Clava (Fig. 3) one-segmented, densely covered with long setae. Scrobal depression with distinct micro-reticulation.</p> <p>Mesosoma (Figs 1, 2, 7). Pronotum (Fig. 7) 0.47× as long as wide; with piliferous punctures except for lateral panel of pronotum. Mesoscutum with complete and distinct notauli (Fig. 7); with a noticeable median mesoscutal carina (Figs 2, 7) that is laterally flanked by rows of piliferous foveae, remaining mesoscutum with piliferous punctures. Dorsal surface of axillae with piliferous punctures, posterior portion of axillae smooth with distinct patch of white setae. Axillulae smooth, dorsally defined by distinct carinae. Mesoscutellum expanded dorsally into keel-like median carina, which is continuous to the median mesoscutal carina (Figs 2, 7). Mesepisternum with distinct and broad mesofemoral depression (Fig. 2), the depression delimited anteriorly by a carina that is ventrally continuous with the epicnemial carina and consisting of two rows of impressions, an anterior row of punctures and a posterior row of foveae; mesepisternum anterior to carina with few setae. Mesepimeron (Fig. 2) glabrous, upper mesepimeron marked by deep impression, lower mesepimeron with weakly marked fovea. Ventral mesopleuron with piliferous foveae; mesofurcal pit large, situated anterior to mesotrochantinal plate; mesodiscriminal line present. Metanotum with metascutellar arms carinate; lateral panel of metanotum consisting of row of large fovea; metascutellum carinate, reaching anterior margin but separated from posterior margin of metanotum. Hind wing tegula present, about 1/3 length of fore wing tegula. Lateral panel of metapleuron with slightly foveolate punctures and distinct white setation. Patch of white setae present on lateral metepisternum posterior to hind wing articulation (Fig. 2). Ventral metepisternum anteriorly smooth, posterior portion irregularly foveolate and greatly expanded between hind coxae. Propodeum with most piliferous punctures foveolate and much larger than on pro- and mesonotum.</p> <p>Legs (Fig. 1). Fore coxa with large piliferous punctures. Mid and hind coxae setose, with microreticulation.</p> <p>Wings (Fig. 1). Length of submarginal vein: 1.17 mm, marginal vein: 0.77 mm, postmarginal vein: 0.15 mm, stigmal vein: 0.09 mm.</p> <p>Metasoma (Figs 1, 9). Length of metasomal tergites in dorsal view (in mm): Mt1 (petiole): 0.92, Mt2: 0.11, Mt3: 0.15, Mt4: 0.35, Mt5: 0.56, Mt6: 0.61, Mt7: 0.65, Mt8/9: 0.16. Petiole with indistinct, shallow reticulation; subrectangular in cross section, with four strong carinae delineating each of the dorso- and ventrolateral margins; dorsal surface with median carina along anterior ¾; lateral surface with additional complete length carina. Postpetiolar metasoma with shallow microreticulation; tergites bare except Mt6 with few isolated setae, Mt7 with patch of setae posterior to spiracles and Mt8/9 setose (Fig. 9). Length of exposed part of ovipositor in dorsal view: 0.10 mm.</p> <p>Male. Unknown.</p> <p> <b>Distribution.</b> Colombia: Amazonas.</p> <p> <b>Etymology.</b> This species is named after Sid, the lazy but big-hearted ground sloth that features in the computer-animated comedy adventure series <i>Ice Age</i>. The name is based on facial resemblance between these two, which is mainly caused by shared bulbous eyes, and the characteristic anteroventral orientation of accompanying structures (hairs in the ground sloth/cuticular frontal projections in the new species).</p> <p> <b>Host.</b> Unknown.</p> <p> <b>Comment.</b> No anellus was described in the two other known species of the <i>A. noyesi</i> species group. The anellus is present in <i>A. noyesi</i> and can even be traced in the original drawing of the holotype (Subba Rao 1978, figs 17, 18). A re-examination of the slide-mounted antenna of the holotype of <i>A. diabolus</i> revealed the presence of a minute, almost linear anellus (Gibson, pers. comm.).</p>Published as part of <i>Arias-Penna, Diana Carolina, Pape, Thomas & Krogmann, Lars, 2014, Stalk-eyed wasps-review of a largely unnoticed group of morphologically bizarre chalcidoid wasps (Hymenoptera: Eurytomidae: Axima), pp. 583-590 in Zootaxa 3866 (4)</i> on pages 585-588, DOI: 10.11646/zootaxa.3866.4.8, <a href="http://zenodo.org/record/4930615">http://zenodo.org/record/4930615</a>
Pubertal Development in Pediatric Kidney Transplant Patients Receiving Everolimus Or Conventional Immunosuppression
No full textPUBERTAL DEVELOPMENT AFTER PEDIATRIC KIDNEY TRANSPLANTATION: COMPARISON BETWEEN EVEROLIMUS-BASED AND CONVENTIONAL IMMUNOSUPPRESSION
No full textPubertal Development in Pediatric Kidney Transplant Patients Receiving Mammalian Target of Rapamycin Inhibitors or Conventional Immunosuppression
No full textBackground. Data regarding the onset of puberty in children receiving mammalian target of rapamycin (mTOR) inhibitors are limited. Methods. Kidney transplant patients aged <14 years were analyzed retrospectively to a maximum age of 18 years, with a minimal observation period of 1 year. Immunosuppression comprised (1) standard CNI-based regimen or (2) low-exposure mTOR inhibitor with reduced-exposure CNI, initiated either de novo or in the maintenance phase. Results. Of 108 children analyzed, 67 received an mTOR inhibitor (56 everolimus, 11 sirolimus) and 41 did not. The age at which girls reached Tanner stage P2 was similar with mTOR inhibitor therapy (median 11.6 years) or without (median 11.1 years) (P = 0.262), as was age at stage B2 (median 11.6 vs. 11.2 years; P = 0.753). In boys, both the age of attaining Tanner stage P2 (median 12.9 vs. 13.0 years; P = 0.796) and Tanner stage G2 (median 13.1 vs. 12.9 years; P = 0.344) were also similar with or without an mTOR inhibitor. Age at menarche in girls, and age at spermarche in boys, did not differ between the 2 groups. Conclusions. In this retrospective analysis, sexual maturation ages and reproductive hormone levels were comparable in adolescent kidney transplant patients receiving low-exposure mTOR inhibitors and reduced CNI therapy or conventional CNI-based immunosuppression
PUBERTAL DEVELOPMENT IN PEDIATRIC KIDNEY TRANSPLANT PATIENTS RECEIVING MAMMALIAN TARGETS OF RAPAMYCIN INHIBITORS OR CONVENTIONAL IMMUNOSUPPRESSION
No full textPUBERTAL DEVELOPMENT AFTER PEDIATRIC KIDNEY TRANSPLANTATION: COMPARISON BETWEEN EVEROLIMUS-BASED AND CONVENTIONAL IMMUNOSUPPRESSION
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