575 research outputs found
CD57 in human natural killer cells and T-lymphocytes
No full textThe CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated ‘senescent’ cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease and discuss how this marker can inform researchers about their likely functions in human blood and tissues in vivo. While CD57 expression on human lymphocytes indicates an inability to proliferate, these cells also display high cytotoxic potential, and CD57pos NK cells exhibit both memory-like features and potent effector functions. Accordingly, frequencies of CD57-expressing cells in blood and tissues have been correlated with clinical prognosis in chronic infections or various cancers and with human aging. Functional modulation of senescent CD57pos T-cells and mature CD57pos NK cells may therefore represent innovative strategies for protection against human immunological aging and/or various chronic diseases
sj-docx-1-jbm-10.1177_03936155231186163 - Supplemental material for Immune checkpoints as potential theragnostic biomarkers for epithelial ovarian cancer
No full textSupplemental material, sj-docx-1-jbm-10.1177_03936155231186163 for Immune checkpoints as potential theragnostic biomarkers for epithelial ovarian cancer by Azza Habel, Xu Weili, Mariem Hadj Ahmed, Mouna Stayoussef, Hanen Bouaziz, Mouna Ayadi, Amel Mezlini, Anis Larbi and Basma Yaacoubi-Loueslati in The International Journal of Biological Markers</p
Ayaanella M.T. Khan & Anis 2017, gen. nov.
No full textAyaanella M.T. Khan & Anis gen. nov. (Figs 1–10) Type species. Ayaanella globugaster M.T. Khan & Anis sp. nov. Description. Female. Head (Fig. 1); antennal torulus placed slightly above lower margin of eye; malar space dark, as long as or shorter than eye width; ocelli arranged in obtuse triangle; mandible (Fig. 2) 4-dentate, third tooth shorter, and a concavity between third and fourth teeth; maxillary palp (Fig. 3) unsegmented, swollen basally, with one seta at apex. Antennal formula 1, 1, (2), 2, 3; antenna (Figs 5–8) with 2 anelli (Figs 7, 8: A1 and A2); funicle 2 segmented, segments asymmetrical, with PLS, F2 broader than long; clava 3-segmented with very long setae and PLS. Mesosoma with pronotum medially divided into two plates; mid lobe of mesoscutum and scutellum each with 2 pairs (2+2) setae; side lobe of mesoscutum with 1 seta along anterolateral corner and axilla; propodeal margin almost straight posteriorly and about as long as metanotum medially; posterior two-thirds of mesoscutum, and scutellum with longitudinally cellulate sculpture, anterior one-third of mesoscutum with polygonal cells. Fore wing hyaline with venation extending to slightly less than half wing length; costal cell very narrow; marginal vein longer than premarginal or stigmal veins; premarginal vein broader than marginal vein; RS1 absent [except two or three setae below stigmal vein]; disc moderately densely setose with setae arranged in rows. Legs with tarsal formula 3-3-3. Metasoma longer than mesosoma; ovipositor short, extending from TV of gaster and hardly exserted. Male. Unknown. Etymology. The genus is named after the son of the second author (SBA), Ayaan + ‘-ella’ Latin suffix added to generic name.Published as part of Khan, Mohd Talib & Anis, Shoeba Binte, 2017, A new genus of Trichogrammatidae (Hymenoptera: Chalcidoidea) from India, pp. 165-168 in Zootaxa 4344 (1) on pages 165-166, DOI: 10.11646/zootaxa.4344.1.9, http://zenodo.org/record/104236
Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's Disease.
No full textAlthough primarily a neurological complaint, systemic inflammation is present in Alzheimer's Disease, with higher than normal levels of proinflammatory cytokines and chemokines in the periphery as well as the brain. A gradient of these factors may enhance recruitment of activated immune cells into the brain via chemotaxis. Here, we investigated the phenotypes of circulating immune cells in AD patients with multi-colour flow cytometry to determine whether their expression of chemokine receptors is consistent with this hypothesis. In this study, we confirmed our previously reported data on the shift of early- to late-differentiated CD4+ T-cells in AD patients. The percentage of cells expressing CD25, a marker of acute T-cell activation, was higher in patients than in age-matched controls, and percentages of CCR6+ cells were elevated. This chemokine receptor is primarily expressed on pro-inflammatory memory cells and Th17 cells. The proportion of cells expressing CCR4 (expressed on Th2 cells) and CCR5 (Th1 cells and dendritic cells) was also greater in patients, and was more pronounced on CD4+ than CD8+ T-cells. These findings allow a more detailed insight into the systemic immune status of patients with Alzheimer's disease and suggest possible novel targets for immune therapy
A One-Way Car-Sharing Based Approach for Combined Shared Mobility of Freight and Passengers
No full textClimate change stresses the need for research and development of innovative sustainable mobility solutions that provide reliable and convenient door-to-door services for both passengers and freight. The increase in urban population and the popularity of e-commerce further highlights the need for action. In this regard, crowd-shipping is often perceived as an efficient, cost-effective, and sustainable alternative (or complement) to the management of urban freight mobility through efficient utilization of current transportation capacities. In this framework, inspired by the concept of MaaS (Mobility as a Service) in integrating various forms of transport and transport-related services into a single on-demand mobility service, this paper proposes a car-sharing-based service for the combined mobility of passengers and freight. In doing so, one-way car-sharing and crowd-shipping concepts are integrated in order to serve part of the existing freight demand in a sustainable and cost-efficient way for users, societies, and the environment. An optimization model is proposed to optimally plan the activation of one-way car-sharing and crowd-shipping services and to determine the optimal number of vehicles to assign to them. Such decisions are aimed at minimizing the total imbalance by serving passenger and freight demand during different time periods. In doing so, the willingness of users to carry freight in their vehicles is also taken into consideration. The capability of the proposed approach is evaluated through representative numerical examples aimed at showing the impact of the model parameters on the solution.Transport and Plannin
Interview with Anis Mansour
No full textلقاء مع الكاتب المصري أنيس منصور حول أبعاد تأثر المنطقة العربية برحلة الرئيس المصري أنور السادات إلى القدس منذ 15 عامًا مضت. أجرت هذاا اللقاء إيمان رافع.An interview with Egyptian journalist and author Anis Mansour about the impact of President Anwar Sadat's 1977 visit to Jerusalem on the Arab region. Interview conducted by Iman Rafi
METFORMIN DECREASES AGING AND DIABETES ASSOCIATED CHRONIC INFLAMMATION AND HAS AN IMMUNOMODULATORY ROLE
No full textPh.DDOCTOR OF PHILOSOPHY (SOM
Interview with Anis Mansour
No full textلقاء مع الكاتب المصري أنيس منصور حول اعجابه بإذاعة "صوت أمريكا" واعجابه بالمذيعين بها. أجرت هذاا اللقاء إيمان رافع.An interview with Egyptian journalist and author Anis Mansour about his admiration for the Voice of America radio station and its broadcasters. Interview conducted by Iman Rafi
Flow cytometry data analysis of the immune system in human aging
No full textChronological aging is often accompanied with increase in acute or chronic co-morbidities. Immunosenescence, the aging of the immune system, was proposed to influence the susceptibility towards diseases in the elderly and chronic latent infections by herpes viruses such as Cytomegalovirus and Epstein-Barr virus are responsible for immunosenescence. Aged immune T-lymphocytes are characterized by the loss of CD28 and the gain of CD57 markers. In addition, another phenomenon known as inflammaging, a low-grade chronic pro-inflammatory state, often accompanies immunosenescence. We show in this study a shift in the T-lymphocyte subsets towards a more CD57+ phenotype in the elderly, and that Herpes Simplex virus 2 and Helicobacter pylori can also influence the shift. Both pro- and anti-inflammatory cytokines (IFN-γ, IL-6, IL-10, TGF-β1 and CRP) are also shown to increase in the elderly as compared to the young, and that immunosenescence and inflammaging appear to occur independently. Further analyses of the physiological parameters, such as blood pressure, with levels of cytokines were also done to determine the probable influence of the elevated levels of cytokines. Gaining knowledge of the presence of such correlations aims to discover possible markers that can reflect the immunosenescence and also the natural aging process.Bachelor of Science in Biological Science
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