122,314 research outputs found
Lokalize vitiligoda 308 NM excimer lamba monoterapisi ile excimer lamba+takrolimus ve excimer lamba+klobetazol 17-propiyonat tedavilerinin etkinliğinin karşılaştırılması
No full textVitiligo etyolojisi bilinmeyen bir depigmentasyon hastalığıdır. Son yıllarda, lokalize vitiligoda excimer ışık tedavileri etkinliğinin yüksek olması ve yan etkilerinin az olması nedeniyle ön plana çıkmaktadır. Çalışmamızda amacımız vitiligoda excimer lamba tedavisinin etkinliğini ve bu tedavinin klobetazol 17-propiyonat %0.05 veya takrolimus %0.1 pomad ile kombinasyonunun etkinliklerini retrospektif olarak değerlendirmekti. Değerlendirme yöntemi olarak Corel Draw X7 bilgisayar programı kullanılarak dijital morfometrik analiz yapılmıştır. Hastaların tedavi öncesi ve 24 seans sonrasında çekilen resimleri karşılaştırılarak iyileşme oranları hesaplanmıştır. Excimer lamba grubunda (n=30) ortalama iyileşme oranı %42.5, excimer lamba+kortikosteroid grubunda (n=23) %44, excimer lamba+takrolimus grubunda (n=29) %69'du. Çalışmamızda excimer lambanın takrolimus %0.01 pomad ile kombinasyonu; excimer lamba monoterapisi ve excimer lambanın klobetazol 17 propiyonat %0.05 pomad ile kombinasyonundan daha etkili bulunmuştur (p=0,08 ve P=0,032). Excimer lamba+kortikosteroid grubunda ortalama kümülatif UV dozu (40200 mJ/cm2), excimer lamba (33050 mJ/cm2) ve excimer lamba+takrolimus grubundan (33800 mJ/cm2) daha yüksek bulunmuştur (p<0,001). Çalışmamızda yaş, hastalık süresi tedavi yanıtını ters orantılı olarak etkilerken; cinsiyet, tedavi öyküsü, deri fototipi tedavi yanıtını etkilememiştir. Lezyon lokalizasyonunun ise tedavi yanıtını etkileyen en önemli faktörlerden biri olduğu sonucuna ulaşılmıştır. Yaş, hastalık süresi, kümülatif UV dozu gibi karıştırıcı faktörlere göre düzeltme yapıldığında sırasıyla yüz (n=24), gövde (n=19), ekstremite (n=16) lezyonları olan hastalarda el-ayak lezyonu olan hastalara (n=23) göre iyileşme oranları daha yüksek bulunmuştur (p<0,01). Sonuç olarak vitiligoda excimer lamba tedavisi etkili bir tedavidir, tedaviye topikal takrolimus %0.1 veya klobetazol 17-propiyonat %0.05 pomad eklenmesiyle daha iyi iyileşme oranları sağlanabilmektedir.Vitiligo is a depigmentation disease of unknown etiology. In recent years excimer light treatments have come to the fore in localized vitiligo because of their high efficacy and few side effects. In our study we aimed to evaluate retrospectively the effectiveness of excimer lamp and the combination of this treatment with clobetasol 17-propionate or tacrolimus %0.1 ointment in vitiligo. Digital morphometric analysis was made using the Corel Draw X7 computer program as an evaluation method. The photographs of the patients taken before the treatment and after 24 sessions were compared to calculate repigmentation rates. The mean repigmentation rate was %42.5 for the excimer lamp group (n=30), %44 for the excimer lamp+corticosteroid group (n=23) and %69 for the excimer lamp+tacrolimus group (n=29). In our study the combination of excimer lamp with topical tacrolimus %0.01 ointment was more effective than excimer lamp monotheraphy and the combination of excimer lamp with clobetasol 17-propionate %0.05 ointment (p=0,08 and p=0,032). The mean cumulative UV dose of excimer lamp+corticosteroid group (40200 mJ/cm2) was higher than excimer lamp (33050 mJ/cm2) and excimer lamp+tacrolimus group (33800 mJ/cm2) (p<0,001). In our study, age and disease duration were reversely proportional with repigmentation rates, however, gender, previous treatments, skin phototype did not affect repigmentation rates. Localisation of the lesions was concluded to be one of the most important factors affecting the treatment responses. When confounding factors such as age, disease duration, cumulative UV dose were adjusted, repigmentation rates of the patients who had lesions on the face (n=24), trunk (n=19), extremity (n=16) were higher than the patients who had lesions on hands and feet (n=23) (p<0,01). In conclusion, excimer lamp therapy is an effective treatment in vitiligo and when it's combined topical tacrolimus %0.1 ointment or clobetasol 17-propionate %0.05 ointment, better repigmentation rates can be obtained
Cooperating Agents for 3D Scientific Data Interpretation
No full textMany organizations collect vast quantities of three-dimensional (3-D) scientific data in volumetric form for a range of purposes, including resource exploration, market forecasting, and process modelling. Traditionally, these data have been interpreted by human experts with only minimal software assistance. However, such manual interpretation is a painstakingly slow and tedious process. Moreover, since interpretation involves subjective judgements and each interpreter has different scientific knowledge and experience, formulation of an effective interpretation often requires the cooperation of numerous such experts. Hence, there is a pressing need for a software system in which individual interpretations can be generated automatically and then refined through the use of cooperative reasoning and information sharing. To this end, a prototype system, SurfaceMapper, has been developed in which a community of cooperating software agents automatically locate and display interpretations in a volume of 3-D scientific data. The challenges and experiences in designing and building such a system are discussed. Particular emphasis is given to the agents' interactions and an empirical evaluation of the effectiveness of different cooperation strategies is presented
Lamba values for eye, orbit, and life history variables under study.
No full text<p>Lamba values for eye, orbit, and life history variables under study.</p
Efficient folding of the FcεRI α-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1
No full textHuman high affinity receptor for IgE is a membrane glycoprotein multi-chain complex presenting two extracellular Ig modules in its α-chain (D1D2). The receptor IgE binding region is located within the membrane-proximal module D2, while the N-terminal module D1 appears to promote an optimal receptor conformation for IgE binding. To understand the structural relationship between the two modules, we dissected FcεRI α-chain into its discrete Ig units and expressed them in mammalian cells. Unexpectedly, D2 was secreted as a disulphide-linked dimer, while D1 was monomeric. Active secretion and full glycosylation of dimeric D2 suggest a native-like conformation of the protein, justifying the escape from the endoplasmic reticulum/Golgi quality control systems. We then propose a domain-swapping model for D2, in which two interdigitated polypeptide chains assume the overall conformation of two Ig modules, as observed for rat CD2 N-terminal domain. Fusion of an unrelated Ig fold moiety at the N terminus of D2 did not interfere with its dimerisation. While D1D2 assumes a correct fold, co-expression of both isolated domains in the same cell did not restore monomeric folding of D2. Thus, D1 appears to assist the appropriate folding of FcεRI α-chain, acting as an uncleavable intramolecular chaperone-like block towards D2. © 2002 Elsevier Science Ltd. All rights reserved
Contribution à l'étude de la palmeraie du pays Kabyè-Losso-Lamba (Nord-Togo )
No full textA Contribution to the Study of the Palm Grove of the Kabye-Losso-Lamba Region, Northern Togo. The economic area of the oil producing palm (Elaeis guineensis Jacq ) in Togo is limited on the North by the Defale Mountain Range, or by 1 200 mm ofisohyet. The oil palm is a beautiful crop in the Kabye-Losso-Lamba sector, a region chararterized by a wet tropical climate during two seasons of the year and by a dense population settlement. This palm grove, situated in the extreme northern part of its usual area of distribution, is one of its distinctive features. Although at the very limit of its climate, it is of natural origin. This natural growth of the Elaeis guineensis has been drastically modified by man, which means that it is sub-spontaneous. Although natural, it exists today because man has used selectioning to maintain it during crop clearing undertaken for its many uses.L'aire écologique du palmier à huile (Elaeis guineensis Jacq) au Togo est limitée vers le nord par la chaîne de Défalé ou par l'isohyète 1 200 mm. Le palmier à huile constitue un beau peuplement dans le pays Kabyè-Losso-Lamba, région caractérisée par un climat tropical humide à deux saisons et par de fortes densités de population. Cette palmeraie située très au nord de son aire habituelle de distribution constitue une originalité. Bien qu' à la limite de son climat, elle est d' origine naturelle. Ce peuplement naturel d ' Elaeis guineensis a été très profondément modifié par l'homme, ce qui fait dire qu'il est subspontané. Quoique naturel, il existe de nos jours parce que sélectionné et entretenu par les populations lors des défrichements culturaux pour ses multiples usages.Tchamie Thiou K. Tanzidani. Contribution à l'étude de la palmeraie du pays Kabyè-Losso-Lamba (Nord-Togo ). In: Cahiers d'outre-mer. N° 192 - 48e année, Octobre-décembre 1995. Togo - Bénin. pp. 501-518
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Copper-catalyzed C-N bond formation via C-H functionalization: facile synthesis of multisubstituted imidazo[1,2- a ]pyridines from N -(2-pyridinyl)enaminones
No full textAn efficient, new copper-catalyzed approach to the construction of the multisubstituted imidazo[1,2- a ]pyridine skeleton from N -(2-pyridinyl)enaminones has been developed
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
Life and worldview: Development and transformation – The case of the Lamba of the Masaiti region in Zambia
No full textThis article reports on a case study regarding the development and educational transformation of a subgroup of the Lamba living in the Masaiti region of the Copper Belt Province of Zambia, where the Foundation for Cross-Cultural Education in Zambia (FCE) has been serving for the past thirteen years. It was concluded that the current life- and worldview of a community such as the one living in the Masaiti region can be transformed to a truly Christ-centred life- and worldview by firstly taking cognisance of how the community currently expresses itself in terms of each of the universals or components of a life and worldview, and secondly by subjecting each of those universals or components to a process of life- and worldview transformation. It was furthermore found that life- and worldview transformation should be seen as a prerequisite for the developmental transformation of such communities.Lewens- en werklikheidsvisie: ontwikkeling en transformasie – 'n gevallestudie oor die Lamba woonagtig in die Masaitistreek van Zambië
Hierdie artikel berig oor 'n gevallestudie aangaande die ontwikkeling en die onderwyskundige transformasie van 'n subgroep van die Lamba, woonagtig in die Masaiti-streek van die Koperbeltprovinsie van Zambië. Die Foundation for Cross-Cultural Education in Zambië (FCE) is reeds die afgelope dertien jaar werksaam onder die mense in hierdie gebied. Daar is tot die gevolgtrekking gekom dat die huidige lewens- en werklikheidsvisie van 'n gemeenskap soos dié van die Masaiti-streek getransformeer sal kan word tot 'n ware Christus-gesentreerde lewens- en werklikheidsvisie. Dit kan gedoen word deur eerstens in ag te neem hoe die gemeenskap homself tans tot uitdrukking bring in terme van elkeen van die universaliteite of komponente van 'n lewens- en werklikheidsvisie, en tweedens deur elkeen van hierdie universaliteite of komponente te onderwerp aan 'n proses van lewens- en werklikheidsbeskouingstransformasie. Daar is ook tot die gevolgtrekking gekom dat lewens- en werklikheidsvisietransformasie beskou moet word as 'n voorvereiste vir die ontwikkelingstransformasie van sodanige gemeenskappe
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