5,660 research outputs found
Computational model of cellular metabolic dynamics in skeletal muscle fibers during moderate intensity exercise
No full textHuman skeletal muscles have different fiber types with distinct metabolic functions and physiological properties. The quantitative metabolic responses of muscle fibers to exercise provide essential information for understanding and modifying the regulatory mechanisms of skeletal muscle. Since in vivo data from skeletal muscle during exercise is limited, a computational, physiologically based model has been developed to quantify the dynamic metabolic responses of many key chemical species. This model distinguishes type I and II muscle fibers, which share the same blood supply. An underlying hypothesis is that the recruitment and metabolic activation of the two main types of muscle fibers differ depending on the pre-exercise state and exercise protocols. Here, activation measured by metabolic response (or enzymatic activation) in single fibers is considered linked but distinct from fiber recruitment characterized by the number (or mass) of each fiber type involved during a specific exercise. The model incorporates species transport processes between blood and muscle fibers and most of the important reactions/pathways in cytosol and mitochondria within each fiber type. Model simulations describe the dynamics of intracellular species concentrations and fluxes in muscle fibers during moderate intensity exercise according to various experimental protocols and conditions. This model is validated by comparing model simulations with experimental data in single muscle fibers and in whole muscle. Model simulations demonstrate that muscle-fiber recruitment and metabolic activation patterns in response to exercise produce significantly distinctive effects depending on the exercise conditions
Continuum soil-structure-interaction model of the LHPOST6 shaking table reaction mass at UC San Diego
No full textThe recently upgraded six Degree-of-Freedom Shaking Table, LHPOST6, at UC San Diego, underwent a series of forced vibration tests to evaluate the postupgrade dynamic response of the foundation-soil system. The resulting data were instrumental in obtaining frequency response curves of the system, which were used to determine its low-strain natural frequencies, effective viscous damping ratios, and reaction mass displacements. The extensive experimental data motivated the creation of a detailed Soil-Structure-Interaction model of the reaction mass-soil system. The structure and soil were modeled using 3D Finite Elements in STKO-OpenSees and calibrated with the acquired data via a parametric study. The 3D continuum FE
model and the calibration procedure based on a single soil parameter (shear wave velocity profile) proved to be an effective tool to reproduce the experimental results accurately. This paper describes the Finite Element model, its calibration, and validation. In addition, the paper provides suggestions to simplify continuum models and promote their use in professional practice. The objectives of this campaign, alongside the growing accessibility of high-performance computing, may serve as a step toward using SSI continuum models in the industry
Draft toxicological profile for JP-5, JP-8, and jet A fuels
Full text linkA Toxicological Profile for JP-5 and JP-8 was released in 1998. This present edition supersedes any previously released draft or final profile.Chemical manager(s)/author(s): John Risher, Obaid Faroon, ATSDR, Division of Toxicology and Human Health Sciences, Atlanta, GA; Fernando Llados, Lisa Ingerman, Mario Citra, SRC, Inc., North Syracuse, NY
Rancang bangun sistem penjualan online pada jp multindo
Full text linkSistem penjualan online adalah suatu sistem transaksi penjualan melalui media elektronik berbentuk website dengan mengunakan media internet. Pada sistem ini pembeli dapat melakukan pemesanan produk secara online
Sebuah perusahaan percetakan yang bergerak dalam bidang promosi dan jasa percetakan yaitu JP Multindo membutuhkan sistem penjualan online. Perusahaan yang beralamat di Jl. Angkasa Kav B.6 Kota Baru Bandar Kemayoran, Jakarta Pusat ini membutuhkan sistem penjualan online untuk membantu dalam proses penjualan. Selain itu sistem penjualan online ini digunakan sebagai media promosi untuk memasarkan produk perusahaan dan pemesanan produk melalui layanan website. Sistem penjualan online JP Multindo dibangun dengan menggunakan bahasa pemograman PHP (Hypertext Preprocessor), HTML (Hypertext Markup Language), CSS (Cascading style), Javascript dan MySQL sebagai basis data. seperti melakukan transaksi pembelian pada umumnya tanpa harus datang ke tempat tujuan
Shock tube study of JP-10 ignition delay time
No full textJP-10 (exo-tetrahydrodicyclopentadiene, C10H16) ignition delay times were measured in a preheated shock tube. The vapor pressures of the JP-10 were measured directly by using a high-precision vacuum gauge, to remedy the difficulty in determining the gaseous concentrations of heavy hydrocarbon fuel arising from the adsorption on the wall in shock tube experiments. The whole variation of pressure and emission of the OH or CH radicals were observed in the ignition process by a pressure transducer and a photomultiplier with a monochromator. The emission of the OH or CH radicals was used to identify the time to ignition. Experiments were performed over the pressure range of 151-556 kPa, temperature range of 1000-2100 K, fuel concentrations of 0.1%-0.55% mole fraction, and stoichiometric ratios of 0.25, 0.5, 1.0 and 2.0. The experimental results show that for the lower and higher temperature ranges, there are different dependency relationships of the ignition time on the temperature and the concentrations of JP-10 and oxygen
Relationship between age at menarche and skeletal maturation stages in Taiwanese female orthodontic patients
No full textRadiographic assessment of skeletal maturation stages for orthodontic patients: Hand-wrist bones or cervical vertebrae?
No full textLong-acting injectable antipsychotics: focus on olanzapine pamoate
No full textJP LindenmayerDepartment of Psychiatry, New York University School of Medicine, New York NY, USAAbstract: Medication non-adherence in patients with schizophrenia continues to be a significant problem and threatens successful treatment outcomes. Medication non-adherence is often associated with negative consequences, including symptom exacerbation, more frequent emergency room visits, re-hospitalizations and relapse. Long-acting injectable (LAI) forms of antipsychotics allow for rapid identification of non-adherence, obviate the need for the patient to take the medication on a daily basis and increase adherence to some significant degree. Eli Lilly has developed a long-acting depot formulation of olanzapine, olanzapine pamoate, which has recently been approved by the FDA for the US market, and which will be reviewed here. Olanzapine LAI appears to be an effective antipsychotic at dosages of 210 mg every 2 weeks, 300 mg every 2 weeks and 405 mg every 4 weeks in patients with acute schizophrenia, and at 150 mg every 2 weeks, 300 mg every 2 weeks and at 405 mg every 4 weeks for the maintenance treatment of stable patients. Oral supplementation appears not to be needed, particularly not at the onset of treatment with the LAI as is necessary with risperidone LAI. Its efficacy is in general comparable to the efficacy seen with oral olanzapine at a corresponding dose. The side effect profile is also comparable to the side effects observed with oral olanzapine, including lower rates of extrapyramidal symptoms, prolactin elevation and cardiovascular side effects, but significant metabolic effects. The latter include significant weight gain, lipid abnormalities and glucose dysregulation. While the injection site adverse events are overall mild, the most significant serious adverse event is the post-injection delirium sedation syndrome (PDSS). While rare, this syndrome results from inadvertent intravascular injection of olanzapine LAI and can cause a range of olanzapine overdose-type of symptoms. Olanzapine LAI needs therefore to be administered by trained personnel in settings where a post-injection observation period for at least 3 hours by medical personnel is available. The overall use of olanzapine LAI will probably be limited by the possibility of a PDSS event. Patients who have a history of good response to oral olanzapine and are in need of assured medication administration may present a good indication for its use, provided that the appropriate mental health delivery setting is available.Keywords: olanzapine, risperidone, schizophreni
Dynamics of Network Formation Processes in the Co-Author Model
Full text linkThis article studies the dynamics in the formation processes of a mutual consent network in game theory setting: the Co-Author Model. In this article, a limited observation is applied and analytical results are derived. Then, 2 parameters are varied: the number of individuals in the network and the initial probability of the links in the network in its initial state. A simulation result shows a finding that is consistent with an analytical result for a state of equilibrium while it also shows different possible equilibria.Dynamics, Network, Game Theory, Model,Simulation, Equilibrium, Complexity
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