177,168 research outputs found
Meccanismi d’azione di nuovi potenziali farmaci ad attività antitumorale, utilizzando sistemi in vitro ed in vivo.
No full textL’insorgenza e la progressione dei tumori maligni ha interessato inizialmente l’aumentata proliferazione cellulare, successivamente si è approfondito il rapporto esistente fra proliferazione emorte cellulare. La morte cxellulare è caratterizzata dalla apoptosis o morte cellulare programmata e necrosi. Da alcuni anni quindi sempre maggior attenzione è stata posta allo sviluppo di farmaci antitumorali che agiscano attraverso l’attivazione del fenomeno apoptotico, infatti, la maggior parte delle cellule neoplastiche muoiono in seguito all’attivazione di una serie di segnali che attivano la via apoptotica e che difetti dell’attivazione di tale fenomeno sono coinvolti nella proliferazione neoplastica. Il lkavoro ha avuto come obbiettivo la determinazione dei meccanismi d’azione di nuove sostanze ad attività antitumorale che presentano diversa origine, attraverso sistemi in vitro ed in vivo. In particolare la ricerca ha riguardato 1) Lo studio di una nuova classe di peptidi ciclici analoghi alle astine naturali 2) La caratterizzazione in vitro degli effetti della 2-metil-arachidoil-2’-fluoro- etilamide ( Met-F-AEA) un analogo metabolicamente stabile dell’anandammide. 3) Immunoagenti diretti contro il recettore tirosin-chinasico ErbB2. 4) La messa a punto di un sistema di imaging ottico e radioisotopico per la rivelazione precoce dei tumori e delle metastasi in vivo
The HPC ReCaS infrastructure towards the simulation of subsurface hydrological processes
No full textWell hydraulics concerns the process of flow toward/from wells, which occurs because of a vertical extraction or injection in the aquifer. The paper shows preliminary tests performed on the high performance computing (HPC) ReCaS infrastructure to compute simulations on the fluctuation of the water table in heterogeneous porous formation based on a stochastic parametrization of the transmissivity field of the aquifer for the horizontal flow around the pumping well. From a computational point of view, the more expensive aspects concern the storage of the samples and the numerical solution of the related boundary value problem. The numerical simulations were carried out by using packages/libraries included in the SCoPE toolkit v.3 available at the HPC ReCaS infrastructure
Software architecture of a distributed problem solving environment for scientific applications
No full text
La libreria del NAG
No full textIntroduzione alla libreria del NAG e al suo utilizzo; descrizione e uso uletrioe del Supplemento Grafico della Libreri
Realizzazione e valutazione delle prestazioni di un'architettura parallela a basso costo
No full textAlgorithm and software overhead: a theoretical approach to performance portability
No full textIn the last years, the portability term has enriched itself with new meanings: research communities are talking about how to measure the degree to which an application (or library, programming model, algorithm implementation, etc.) has become “performance portable”. The term “performance portability” has been informally used in computing communities to substantially refer to: (1) the ability to run one application across multiple hardware platforms; and (2) achieving some decent level of performance on these platforms [1, 2]. Among the efforts related to the “performance portability” issue, we note the annual performance portability workshops organized by the US Department of Energy [3]. This article intends to add a new point of view to the performance portability issue, starting from a more theoretical point of view, that shows the convenience of splitting the proper algorithm from the emphoverhead, and exploring the different factors that introduce different kind of overhead. The paper explores the theoretical framework to get a definition of the execution time of a software but that definition is not the point. The aim is to show and understand the link between that execution time and the beginning of the design, to exploit what part of any program is really environment-sensitive and exclude from performance portability formulas everything is not going to change, as theoretically shown
Evidence on the prevalence and geographic distribution of major cardiovascular risk factors in Italy
No full textObjective: To assess the prevalence and geographic distribution of major cardiovascular risk factors in a large community-wide sample of the Italian population.
Design: A cross-sectional survey. Standardized methods were used to collect and measure cardiovascular risk factors. Data were adjusted for survey weightings. Qualitative and quantitative variables were compared with parametric and non-parametric tests, as appropriate.
Setting: Towns (n 193) across different Italian regions.
Subjects: Unselected adults (n 24 213; 12 626 men; 11 587 women) aged 18–98 years (mean age 56·9 (sd 15·3) years), who volunteered to participate in a community-wide screening programme over a 2 d period in 2007.
Results: Overall, the prevalence of major cardiovascular risk factors was: obesity, 22·7 % (women 18·9 %, men 26·1 %); overweight, 44·7 % (women 31·6 %, men 56·7 %); hypertension, 59·6 % (women 48·3 %, men 70·0 %); dyslipidaemia, 59·1 % (women 57·7 %, men 60·3 %); diabetes, 15·3 % (women 11·2 %, men 19·0 %) and smoking, 19·8 % (women 14·0 %, men 25·2 %). We found a high prevalence of unhealthy eating habits; fruit and vegetable consumption was below the recommended range in 60 % of the study population. Ninety per cent of the study population had more than one cardiovascular risk factor and 84 % had between two and five cardiovascular risk factors. There were differences among Italian macro-areas mainly for obesity, hypertension, dyslipidaemia and diabetes.
Conclusions: The study provides alarming evidence on current prevalence data for major cardiovascular risk factors in a large sample of the Italian population. Particularly, obesity and hypertension represent a relevant public health problem. There is a pressing need for effective preventive health measures which must also take into account the differences among Italian macro-areas
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