1,721,009 research outputs found
Localized vascular lesions of the glans in patients with lichen sclerosus diagnosed by dermatoscopy.
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Differentiation of pityriasis lichenoides chronica from guttate psoriasis by dermoscopy
No full textSummary Clinical differentiation between pityriasis lichenoides chronica (PLC) and guttate psoriasis (GP) may sometimes be a difficult task, which often requires histological analysis to reach a definitive diagnosis. In this study, PLC and GP lesions were examined using dermoscopy, and the significance of specific dermoscopic findings was investigated in order to facilitate their differentiation and decrease the number of cases requiring biopsy. We found that the incidence of orange-yellowish structureless areas, focal dotted vessels and nondotted vessels was statistically significant in PLC, while the incidence of diffuse dotted vessels was statistically significant in GP
A novel azelaic acid formulation for the topical treatment of inflammatory rosacea. A multicentre, prospective clinical trial
Full text linkA b s t r a c t B a c k g r o u n d : Topical azelaic acid (AzA) is a common treatment for mild/moderate in-flammatory rosacea. A i m s : To assess the efficacy and tolerability of a novel formulation cream contain-ing 15% AzA (anti- inflammatory/anti- oxidant/anti- microbial agent) combined with 1% dihydroavenanthramide D (anti- inflammatory/anti- itch) in inflammatory rosacea using clinical/instrumental evaluation. Methods : In this multicentre, prospective, open- label trial, 45 patients with mild/moderate inflammatory rosacea enrolled at the Dermatology Clinic of the University of Catania, Naples, and Rome (Italy) were instructed to apply the cream twice daily for 8 weeks. Clinical evaluation was performed at baseline (T0) and at 8 weeks (T1) by (1) Investigator Global Assessment (IGA) score based on a 5- point scale (from 0 = clear/no erythema/papules/pustules to 4 = severe erythema/several papules/pustules) and (2) inflammatory lesions count. Instrumental evaluation of erythema degree was per-formed by erythema- directed digital photography (EDDP) by a 5- point scale (from 0 = no redness to 4 = severe redness) at all time points. Tolerability was assessed by a self- administered questionnaire at 8 weeks. Statistical analysis was performed using SAS version 9. Results : Forty- four patients completed the study. At week 8, a significant decrease in baseline of IGA scores [median from 3 (T0) to 1 (T1)] and inflammatory lesions count [median from 8 (T0) to 1 (T1)] was recorded along with a significant reduction of ery-thema scores [median from 2 (T0) to 1 (T1)]. No relevant side effects were recorded. Conclusions : Our results suggest that this new non- irritating product represents a valid therapeutic option for mild/moderate inflammatory rosacea, and EDDP is able to provide a more defined evaluation of erythema changes
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