28 research outputs found
Leilani Darnell Living Memoirs Interview
No full textLeilani shared about her long history in the Adventist faith and her love for God. She told of her time working at Kendu Adventist Hospital in Kendu Bay, Kenya, and her travels during her time as a student missionary there.
Kenya is a country in East Africa consisting of beaches, the Rift Valley, and a diverse population. The language groups in Kenya are categorized as the broad Bantu, Nilo-Saharan, and Afro-Asiatic languages but include many languages from the many migrations of European and Middle-Eastern groups. Kenya is known for its 50 national parks and reserves, the author Ngugi wa Thiong’o, the Nobel prize winner Wangari Muta Maathai, and its rich history.
Ingham, K., Ntarangwi, Mwenda and Ominde, Simeon Hongo. Kenya. Encyclopedia Britannica, December 10, 2023. https://www.britannica.com/place/Kenya.
Views expressed do not represent Southern Adventist University or McKee Library but are the personal opinions of the interviewed individual
Poems
No full textTitle(s): Sappho's Last Dream, The Stroke and After Words
Leilani R. Hall is author of the poetry collection Swimming the Witch. Her poetry and essays have appeared in numerous journals, including the Laurel Review, the Cincinnati Review, North American Review, and the Mississippi Review. She teaches creative writing, poetics, and disability studies at California State University Northridge
Preparation and evaluation of amphiphilic macromolecules-based conjugates and micelles for anticancer drug delivery:
No full textMicelles assembled from amphiphilic macromolecules (AM) or drug-conjugated AMs were evaluated as anticancer drug carriers in terms of drug content,
sustained/controlled drug release and cytotoxicity of encapsulated/bound drug. Physical drug encapsulation was compared with chemical drug conjugation. The AM micelles were compared with known polymeric delivery systems, Pluronic P85 and Cremophor EL. Generally, AM micelles encapsulated drugs as efficiently (or better) than the established polymeric carriers.
Encapsulated hydrophobic drugs in AM micelles showed non-aggregation of drug and sustained drug release after lyophilization and resolubilization in aqueous solutions; indicating good solution and storage stability of drug-loaded AM micelles. Compared to the polymeric controls, the AM micelles showed faster resolubilization times and better pH/temperature micellar stability.
Cellular entry of AM micelles in human umbilical vein endothelial cells was observed to be endocytotic, observed from the colocalization of fluorescein-labeled AMs and fluorescent dye-stained endosomes or lysosomes that were detected by confocal scanning
microscopy.
Doxorubicin (DOX) was conjugated to AMs via acidic pH-sensitive hydrazone linkers and the DOX-AM micelles had ~ 30 nm sizes. DOX-AMs showed higher drug release at lysosomal pH 5.0 as compared to physiological pH 7.4. Cell proliferation assays of DOX-AM micelles showed better cytotoxicity compared to DOX-loaded AM micelles and free DOX against human hepatocellular carcinoma cells.
As another example of drug conjugation, camptothecin (CPT) was conjugated to AMs via glycine linkers. CPT-AM micelles showed CPT lactone stabilization, higher CPT solubilization, and increased stability against human serum albumin (HSA) on CPT release in vitro. However, cell proliferation assays on the CPT-AM micelles showed comparable cytotoxicity to CPT-loaded AM micelles against human colorectal carcinoma cells.
The placement of CPT conjugation was evaluated by CPT conjugation via mucic acid and functionalized alkyl chains. Carbodiimides were used to conjugate CPT to AM mucic acid, whereas click chemistry conjugated alkyne-terminated CPT to azideterminated AM chains. Higher CPT conjugation was achieved via the functionalized chain ends (i.e. click chemistry) compared to the mucic acid (carbodiimide coupling).
However, lesser HSA impact on CPT in vitro release was observed in CPT attached to the mucic acid.
Overall, the AM-based micelles showed good characteristics as anticancer drug carriers.Ph.D.Includes bibliographical referencesby Leilani Singson del Rosari
Lisa
No full textLisa is a video documentary on Ms. Lisa Macuja, a Filipina ballet dancer. The documentary traces Ms. Macuja\u27s development as a dancer, from her early ballet training at the St. Theresa\u27s College, to her stay in the Soviet Union, up to her becoming the first artist-in-residence of the Cultural Center of the Philippines. The documentary discusses the different aspects in Ms. Macuja\u27s career that make her very promising. The main bulk of the documentary consists of interviews. The persons interviewed, aside from Ms. Macuja are her mother, Susan Macuja, Ballet Philippines\u27 Nonoy Froilan, William Morgan, Edna Vida, dance teachers Felicitas Tita Radaic and Basilio Villaruz, and critic Pablo Tariman. Lisa Macuja, being the subject of the documentary, provided the backbone for the documentary, while the other persons interviewed provided supplementary discussions. Excerpts from Ms. Macuja\u27s dances and footage of her in the Soviet Union, with friends, teaching, etc. were included. This 26-minute video documentary was shot entirely using the beta format, but was edited in U-matic. To ensure the smooth flow of the topics discussed in the documentary, a narrator was used
Granny's Best Recipes
No full textCreated as part of ART 147 - Graphic Design: Digital Illustration. Taught by Professor Holly McCabe during the Fall 2023 semester."A collection of passed down family culinary treasures. Down home recipes to warm the soul." - The Autho
Behavior-driven optimization techniques for scalable data exploration
No full textThesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 153-162).Interactive visualizations are a popular medium used by scientists to explore, analyze and generally make sense of their data. However, with the overwhelming amounts of data that scientists collect from various instruments (e.g., telescopes, satellites, gene sequencers and field sensors), they need ways of efficiently transforming their data into interactive visualizations. Though a variety of visualization tools exist to help people make sense of their data, these tools often rely on database management systems (or DBMSs) for data processing and storage; and unfortunately, DBMSs fail to process the data fast enough to support a fluid, interactive visualization experience. This thesis blends optimization techniques from databases and methodology from HCI and visualization in order to support interactive and iterative exploration of large datasets. Our main goal is to reduce latency in visualization systems, i.e., the time these systems spend responding to a user's actions. We demonstrate through a comprehensive user study that latency has a clear (negative) effect on users' high-level analysis strategies, which becomes more pronounced as the latency is increased. Furthermore, we find that users are more susceptible to the effects of system latency when they have existing domain knowledge, a common scenario for data scientists. We then developed a visual exploration system called Sculpin that utilizes a suite of optimizations to reduce system latency. Sculpin learns user exploration patterns automatically, and exploits these patterns to pre-fetch data ahead of users as they explore. We then combine data-prefetching with incremental data processing (i.e., incremental materialization) and visualization-focused caching optimizations to further boost performance. With all three of these techniques (pre-fetching, caching, and pre-computation), Sculpin is able to: create visualizations 380% faster and respond to user interactions 88% faster than existing visualization systems, while also using less than one third of the space required by other systems to store materialized query results.by Leilani Battle.Ph. D
Raven Leilani Named Grisham Writer-in-Residence
No full textPrize-winning author to teach course, lecture during spring 2022 semeste
Ethical Data Management and Research Integrity in the Context of E-Schools and Community Engagement
No full textThe purpose of this chapter is to build on the existing literature in the field of research methodology, specifically as applicable in terms of ethical data management and research integrity, and especially in the context of e-schools and community engagement. This chapter should also enable readers to understand why ethics is important in research relating to e-schools and community engagement. Finally, the author identifies other elements critical to the responsible conduct of research in areas such as those of e-schools and community engagement. The chapter thus provides the reader with an overview of ethical issues in quantitative and qualitative data collection and guidelines for such data processing. </jats:p
