18 research outputs found
Jacarandosa
No full textDaniela Labastida Salinas nació en la Ciudad de México. Es licenciada en Diseño y Comunicación Visual por la UNAM, maestra en Letras Modernas por la Universidad Lumière Lyon 2 y tiene estudios en Cine y en LIJ. Se ha desempeñado como fotógrafa y diseñadora gráfica independiente. Interesada en los idiomas y en la mediación cultural, participó en un intercambio de asistentes de idioma entre México y Francia del CIEP y ha formado parte de diversos proyectos colectivos de promoción a la lectura.Y con el último aliento de un silencioso invierno, florece una risa
Talking about the limits of legal change: an interview with Marc Galanter
No full textRecognized as one of the central figures of the Law & Society and as one of the first editors of the Law & Society Review, Marc Galanter is the author of pioneer and internationally recognized studies on the legal system and patterns of litigation (including "Why the haves come out ahead: Speculations on the Limits of Legal Change", one of the most cited articles in legal literature), lawyers and legal culture, legal institutions and informal regulation, among others. In this interview, Galanter speaks mostly about his academic and professional trajectory, a narrative that is intertwined with the history of tha Law & Society movement itself and with some of the most important developments in American academia since the 60s to the present day. The author also talks about the growth of law firms (described in Tournament of Lawyers) and cultural perceptions currently surrounding lawyers and the legal profession. He discusses the importance of the studies he developed in India for his work, including the famous "Why the haves come out ahead", a piece that is still relevant in the current context.</span
Teleost skin, an ancient mucosal surface that elicits gut-like immune responses
No full textSkin homeostasis is critical to preserve animal integrity. Although the skin of most vertebrates is known to contain a skin-associated lymphoid tissue (SALT), very little is known about skin B-cell responses as well as their evolutionary origins. Teleost fish represent the most ancient bony vertebrates containing a SALT. Due to its lack of keratinization, teleost skin possesses living epithelial cells in direct contact with the water medium. Interestingly, teleost SALT structurally resembles that of the gut-associated lymphoid tissue, and it possesses a diverse microbiota. Thus, we hypothesized that, because teleost SALT and gut-associated lymphoid tissue have probably been subjected to similar evolutionary selective forces, their B-cell responses would be analogous. Confirming this hypothesis, we show that IgT, a teleost immunoglobulin specialized in gut immunity, plays the prevailing role in skin mucosal immunity. We found that IgT(+) B cells represent the major B-cell subset in the skin epidermis and that IgT is mainly present in polymeric form in the skin mucus. Critically, we found that the majority of the skin microbiota are coated with IgT. Moreover, IgT responses against a skin parasite were mainly limited to the skin whereas IgM responses were almost exclusively detected in the serum. Strikingly, we found that the teleost skin mucosa showed key features of mammalian mucosal surfaces exhibiting a mucosa-associated lymphoid tissue. Thus, from an evolutionary viewpoint, our findings suggest that, regardless of their phylogenetic origin and tissue localization, the chief immunoglobulins of all mucosa-associated lymphoid tissue operate under the guidance of primordially conserved principles.Skin homeostasis is critical to preserve animal integrity. Although the skin of most vertebrates is known to contain a skin-associated lymphoid tissue (SALT), very little is known about skin B-cell responses as well as their evolutionary origins. Teleost fish represent the most ancient bony vertebrates containing a SALT. Due to its lack of keratinization, teleost skin possesses living epithelial cells in direct contact with the water medium. Interestingly, teleost SALT structurally resembles that of the gut-associated lymphoid tissue, and it possesses a diverse microbiota. Thus, we hypothesized that, because teleost SALT and gut-associated lymphoid tissue have probably been subjected to similar evolutionary selective forces, their B-cell responses would be analogous. Confirming this hypothesis, we show that IgT, a teleost immunoglobulin specialized in gut immunity, plays the prevailing role in skin mucosal immunity. We found that IgT(+) B cells represent the major B-cell subset in the skin epidermis and that IgT is mainly present in polymeric form in the skin mucus. Critically, we found that the majority of the skin microbiota are coated with IgT. Moreover, IgT responses against a skin parasite were mainly limited to the skin whereas IgM responses were almost exclusively detected in the serum. Strikingly, we found that the teleost skin mucosa showed key features of mammalian mucosal surfaces exhibiting a mucosa-associated lymphoid tissue. Thus, from an evolutionary viewpoint, our findings suggest that, regardless of their phylogenetic origin and tissue localization, the chief immunoglobulins of all mucosa-associated lymphoid tissue operate under the guidance of primordially conserved principles
Role of late maternal thyroid hormones in cerebral cortex development: An experimental model for human prematurity
No full textHypothyroxinemia affects 35-50% of neonates born prematurely (12% of births) and increases their risk of suffering neurodevelopmental alterations. We have developed an animal model to study the role of maternal thyroid hormones (THs) at the end of gestation on offspring's cerebral maturation. Pregnant rats were surgically thyroidectomized at embryonic day (E) 16 and infused with calcitonin and parathormone (late maternal hypothyroidism [LMH] rats). After birth, pups were nursed by normal rats. Pups born to LMH dams, thyroxine treated from E17 to postnatal day (P) 0, were also studied. In developing LMH pups, the cortical lamination was abnormal. At P40, heterotopic neurons were found in the subcortical white matter and in the hippocampal stratum oriens and alveus. The Zn-positive area of the stratum oriens of hippocampal CA3 was decreased by 41.5% showing altered mossy fibers' organization. LMH pups showed delayed learning in parallel to decreased phosphorylated cAMP response element-binding protein (pCREB) and phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2) expression in the hippocampus. Thyroxine treatment of LMH dams reverted abnormalities. In conclusion, maternal THs are still essential for normal offspring's neurodevelopment even after onset of fetal thyroid function. Our data suggest that thyroxine treatment of premature neonates should be attempted to compensate for the interruption of the maternal supply. © The Author 2009.Spanish MICINN Grant (PN I+D+I SAF2006-14068 and FIS 05/PI050590).Peer Reviewe
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
No full textAcuin, Cecilia (IRRI author
Recursos tecnológicos: Una herramienta para favorecer el aprendizaje de los estudiantes de Licenciatura en Lengua Castellana e Inglés (LLCI) en modalidad remota
No full textEste proyecto de investigación tiene como finalidad exponer las problemáticas más recurrentes en la educación virtual, las cuales consisten en el poco uso de herramientas tecnológicas en las aulas de clase, y finalmente resolver la pregunta ¿Cómo apoyar el proceso integral de enseñanza aprendizaje de los estudiantes de quinto semestre en el curso English Literature, como parte del plan de estudios de la carrera de Licenciatura en Lengua Castellana e Inglés (LCI) del quinto semestre de la Universidad Cooperativa de Colombia (UCC)? Todo esto abordado desde un aspecto cualitativo, lo cual permitió conocer las perspectivas de los estudiantes en cuanto a los recursos digitales y metodologías implementadas en el salón de clase. Adicionalmente, los referentes principales fueron Jean Piaget y Lev Vigotsky con sus teorías respecto al aprendizaje mediado por el entorno; de igual forma, se trataron conceptos como lo Recursos Tecnológicos por medio del autor Alegría M. y su aporte a la facilitación de la tecnología en el aula; Aulas Virtuales y su autora Aguilar M.; la Literatura y su Estética; las TIC con el apoyo teórico de Hernández R; Estrategias Pedagógicas y Metodológicas por medio de Mario Bunge. También se decidió implementar un método teórico con enfoque de sistemas para la estructuración y sistematización de la propuesta didáctica que se fue desarrollando a lo largo de la investigación, esta contó con instrumentos de recolección de datos como: la encuesta, la entrevista, la observación no participante y el diario de campo implementadas en el curso English Literature de quinto semestre de la UCC. Los resultados de estos instrumentos nos llevaron a la creación de una secuencia didáctica sistematizada en 4 sesiones de una hora, dando como resultado a estudiantes más entusiasmados y participativos en la presentación del producto final que consistió en realizar un análisis poético utilizando diversos recursos tecnológicos como apoyo visual. De esta manera, se identificó que los estudiantes pudieron conocer nuevas herramientas tecnológicas, así como también se desarrolló la creatividad al momento de usarlas para presentar un producto completo, llamativo y que cumpliera con la rúbrica planteada, es decir, que se promovió una participación activa a través del uso de las TIC, pero al mismo tiempo, se fomentó que los estudiantes tuvieran un buen análisis y comunicación en el lenguaje escrito y oral para de esta forma generar procesos de criticidad y resolución de problemas.This research project aims to expose the most recurrent problems in virtual education, which consist of the little use of technological tools in the classroom, and finally solve the question: How to support the comprehensive teaching-learning process in the English Literature course, as part of the curriculum of the fifth semester LCI career at the Universidad Cooperativa de Colombia? All this was approached from a qualitative aspect, which allowed us to know the perspectives of the students regarding the digital resources and methodologies implemented in the classroom. Additionally, the main references were Jean Piaget and Lev Vigotsky with their theories regarding learning mediated by the environment, in the same way, topics such as: technological resources through the author Alegría M and his contribution to the facilitation of technology were discussed in the classroom, virtual classrooms and its author Aguilar M, literature and its aesthetics, TIC with the theoretical support of Hernández R, pedagogical strategies and methodologies through Mario Bunge. A theoretical method with a systems approach was also implemented for the structuring and systematization of the didactic proposal
that was developed throughout the investigation, it had data collection instruments such as the survey, interview, non-participant observation and the field diary implemented in the English Literature course of the fifth semester of the Cooperative University of Colombia. In this way, it was identified that students will be able to learn about new technological tools, as well as creativity when using them to present a complete, striking product that complies with the signature, that is, that an active participation was promoted to through the use of TIC, but at the same time, students were encouraged to have a good analysis and communication in written and oral language in order to generate processes of criticality and problem solving.1. Introducción. -- 2. Situación problemática. -- 3. Problema de Investigación. -- 4. Contexto sociocultural. -- 5. Justificación. -- 6. Objetivos. -- 7. Objetivo general. -- 8. Objetivos específicos. -- 9. Preguntas científicas. -- 10. Tipo de investigación. -- 11. Métodos de investigación. -- 12. Población y muestra. -- 14. Capítulo I: Uso de las TIC en los procesos de enseñanza-aprendizaje mediante la modalidad combinada. -- 15. Capítulo II: Metodología. -- 16. Instrumentos y validación de los instrumentos. -- 17. Análisis e interpretación de los resultados. -- 18. Capítulo III: La secuencia didáctica como apoyo en el proceso integral de aprendizaje de los estudiantes. -- 19. Fase I: Caracterización. -- 20. Descripción de la población. -- 21. Prueba diagnóstica y análisis de resultados. -- 22. Fase II: Propuesta. -- 23. Descripción de la situación que originó la propuesta. -- 24. Descripción y título de la propuesta. -- 25. Creación de la secuencia didáctica. -- 26. Esquema general de la secuencia didáctica. -- 27. Planeaciones. -- 28. Rejilla de evaluación del producto final. -- 29. Justificación. -- 30. Transversalidad con otras áreas. -- 31. Objetivos de la propuesta. -- 32. Objetivo general. -- 33. Objetivos específicos. -- 34. Fase III: Plan Operativo Del Proyecto. -- 35. Metodología didáctica para emplear. -- 36. Diseño del plan de acción. -- 37. Fase IV: Balance De La Propuesta. -- 38. Análisis y triangulación de instrumentos. -- 39. Análisis de los resultados del proceso de aprendizaje. -- 40. Fortalezas, debilidades y obstáculos. -- 41. Conclusiones. -- 42. Recomendaciones. -- 43. Referencias bibliográ[email protected]@[email protected]@campusucc.edu.c
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
No full textCorrection to "The power of genetic diversity in genome-wide association studies of lipids
The power of genetic diversity in genome-wide association studies of lipids (Author Correction: vol 600, pg 675, 2021)
No full textHumoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults
No full textIndexación: ScopusBackground: The Omicron variant has challenged the control of the COVID-19 pandemic due to its immuno-evasive properties. The administration of a booster dose of a SARS-CoV-2 vaccine showed positive effects in the immunogenicity against SARS-CoV-2, effect that is even enhanced after the administration of a second booster. Methods: During a phase-3 clinical trial, we evaluated the effect of a second booster of CoronaVac®, an inactivated vaccine administered 6 months after the first booster, in the neutralization of SARS-CoV-2 (n = 87). In parallel, cellular immunity (n = 45) was analyzed in stimulated peripheral mononuclear cells by flow cytometry and ELISPOT. Findings: Although a 2.5-fold increase in neutralization of the ancestral SARS-CoV-2 was observed after the second booster when compared with prior its administration (Geometric mean units p < 0.0001; Geometric mean titer p = 0.0002), a poor neutralization against the Omicron variant was detected. Additionally, the activation of specific CD4+ T lymphocytes remained stable after the second booster and, importantly, equivalent activation of CD4+ T lymphocytes against the Omicron variant and the ancestral SARS-CoV-2 were found. Interpretation: Although the neutralizing response against the Omicron variant after the second booster of CoronaVac® was slightly increased, these levels are far from those observed against the ancestral SARS-CoV-2 and could most likely fail to neutralize the virus. In contrast, a robust CD4+T cell response may confer protection against the Omicron variant. Funding: The Ministry of Health, Government of Chile, the Confederation of Production and Commerce, Chile and SINOVAC Biotech. NIH NIAID. The Millennium Institute on Immunology and Immunotherapy. © 2023 The Author(s)https://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S2352396423001287?via%3DihubWe would like to thank the support of the Ministry of Health, Government of Chile; Ministry of Science, Technology, Knowledge, and Innovation, Government of Chile; The Ministry of Foreign Affairs, Government of Chile, and the Chilean Public Health Institute (ISP). We also would like to thank PATH for their active support in experimental design and scientific discussion. We also thank the Vice Presidency of Research (VRI), the Direction of Technology Transfer and Development (DTD) and the Legal Affairs Department (DAJ) of the Pontificia Universidad Católica de Chile. We are grateful to the Administrative Directions of the School of Biological Sciences and the School of Medicine of the Pontificia Universidad Católica de Chile for their administrative support. We would also like to thank to the data safety monitoring committee for their oversight, and finally to the subjects enrolled in the study for their participation and commitment with this trial. The CoronaVac03CL Study was funded by The Ministry of Health, Government of Chile, the Confederation of Production and Commerce (CPC), Chile and SINOVAC Biotech. NIH NIAID, under Contract 75N93021C00016, supports AS and Contract 75N93019C00065 supports AS, AG and DW. The Millennium Institute on Immunology and Immunotherapy, Agencia Nacional de Investigación y Desarrollo (ANID) – Millennium Science Initiative Program – ICN09_016/ICN 2021_045: Millennium Institute on Immunology and Immunotherapy (ICN09_016/ICN 2021_045; former P09/016-F) supports SMB, KA, PAG and AMK; The Innovation Fund for Competitiveness FIC-R 2017 (BIP Code: 30488811-0) supports SMB, PAG and AMK.S
Understanding national trends in COVID‐19 vaccine hesitancy in Canada – April 2020 to March 2021
No full textObjective: Key to reducing COVID‐19 morbidity and mortality and reducing the need for further lockdown measures in Canada and worldwide is widespread acceptance of COVID‐19 vaccines. Vaccine hesitancy has emerged as a key barrier to achieving optimal vaccination rates, for which there is little data among Canadians. This study examined rates of vaccine hesitancy and their correlates among Canadian adults. Methods: This study analyzed data from five age, sex and province‐weighted population‐based samples to describe rates of hesitancy between April 2020 and March 2021 among Canadians who completed online surveys as part of the iCARE Study, and various sociodemographic, clinical and psychological correlates. Vaccine hesitancy was assessed by asking: “If a vaccine for COVID‐19 were available today, what is the likelihood that you would get vaccinated?” Responses were dichotomized into ‘very likely’, ‘unlikely’, ‘somewhat unlikely’ (reflecting some degree of vaccine hesitancy) vs ‘extremely likely’ to get the vaccine, which was the comparator. Results: Overall, 15,019 respondents participated in the study. A total of 42.2% of respondents reported vaccine hesitancy over the course of the study, which was lowest during surveys 1 (April 2020) and 5 (March 2021) and highest during survey 3 (November 2020). Fully adjusted multivariate logistic regression analyses revealed that women, those aged 50 and younger, non‐Whites, those with high school education or less, and those with annual household incomes below the poverty line in Canada (i.e., $60,000) were significantly more likely to report being vaccine hesitant over the study period, as were essential and healthcare workers, parents of children under the age of 18, and those who do not get regular flu vaccines. Believing engaging in infection prevention behaviours (like vaccination) is important for reducing virus transmission and high COVID‐19 health concerns (being infected and infecting others) were associated with 77% and 54% reduction in vaccine hesitancy, respectively, and having high personal financial concerns (worried about job or income loss) was associated with 1.33 times increased odds of vaccine hesitancy. Conclusion: Results point to the importance of targeting vaccine efforts to women, younger people and socioeconomically disadvantaged groups, and that vaccine messaging should emphasize the benefits of getting vaccinated, and how the benefits (particularly to health) far outweigh the risks. Future research is needed to monitor ongoing changes in vaccine intentions and behaviour, as well as to better understand motivators and facilitators of vaccine acceptance, particularly among vulnerable groups. The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license
