628 research outputs found

    Short Stature Diagnosis and Referral

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    The “360° GH in Europe” meeting, which examined various aspects of GH diseases, was held in Lisbon, Portugal, in June 2016. The Merck KGaA (Germany) funded meeting comprised three sessions entitled “Short Stature Diagnosis and Referral,” “Optimizing Patient Management,” and “Managing Transition.” Each session had three speaker presentations, followed by a discussion period, and is reported as a manuscript, authored by the speakers. The first session examined current processes of diagnosis and referral by endocrine specialists for pediatric patients with short stature. Requirements for referral vary widely, by country and by patient characteristics such as age. A balance must be made to ensure eligible patients get referred while healthcare systems are not over-burdened by excessive referrals. Late referral and diagnosis of non-GH deficiency conditions can result in increased morbidity and mortality. The consequent delays in making a diagnosis may compromise the effectiveness of GH treatment. Algorithms for growth monitoring and evaluation of skeletal disproportions can improve identification of non-GH deficiency conditions. Performance and validation of guidelines for diagnosis of GH deficiency have not been sufficiently tested. Provocative tests for investigation of GH deficiency remain equivocal, with insufficient information on variations due to patient characteristics, and cutoff values for definition differ not only by country but also by the assay used. When referring and diagnosing causes of short stature in pediatric patients, clinicians need to rely on many factors, but the most essential is clinical experience

    On a study of the language of J.I. Kraszewski's epistolary output : two more letters not recorded in 'Nowy Korbut'

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    Considerations in the paper are focused on two questions: 1. the state of a study on language of ample mail of the most prolific Polish writer, J.I. Kraszewski; 2. description of two letters of the writer not recorded in 'Nowy Korbut' and being in possession of the Main Library of Świętokrzyska Academy in Kielce. Estimating the state of a study on language of J.I. Kraszewski’s epistolary output the author presents the beginnings of her interest in the language of letters and novels by the writer, achievements in a study of elements of the borderland Polish testified in the writer’s mail and in linguo-slylistic analyses of manuscripts of the writer’s letters (by M. Olma). The author writes also about difficulties that researchers of Kraszewski’s manuscripts face and about their responsibility for results of a study. The second part of the paper contains complete characterization of two letters mentioned above The author reads both manuscripts, edits them protecting their original spelling and punctuation, determines the date of the letter written in Żytomierz (in the year 1858), informs who its addressees were, and finally characterizes the handwriting, spelling and phonetics of the described texts

    Interview with Jens Zimmermann: Author of ‘Hermeneutics: A Very Short Introduction’

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    Dr. Jens Zimmermann is a German-Canadian philosopher and J.I. Packer Professor of Theology at Regent College. As the author of Hermeneutics: A Very Short Introduction, he held a lecture titled “Gadamer, Ricoeur and the Future of Philosophical Hermeneutics” at SFU. Hosted by the Department of World Languages and Literatures, the lecture focused on how we can use the art of hermeneutics to interpret literature and our identities of being human

    Acts of the 19th century politeness etiquette (on the base of J.I. Kraszewski's letters to Wł. Chodźkiewicz)

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    The paper deals with the issue from the field of speech act theory including a study of a collection of about 220 private letters dating from the latter part of the 19th century. Several speech acts like greetings, farewells, thanks, apologies, and wishes were arranged to show differentiation of their illocutionary power as well as different character of the studied text types. It was also described how the author of the letters (J.I. Kraszewski) had been using particular traditional expressions of great antiquity giving them not commonplace form if necessary. The relations between types of the analyzed texts and localization of acts of politeness etiquette was also considered. The aim of such politeness acts is to inform about positive emotions that the sender of these expressions feels to the receiver of them. Conventionalisms having been prevalent in the 19th century were considered from the perspective of their primary function of constant creation and maintaining special politeness atmosphere of relations between people

    Hunting Party

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    Photograph - A group of men with guns on the shore in front of a boat. Athabasca, Alberta. Left to right: Charles Nancekivell, Mr. A.C. McKay, Chinese cook, J.I. Case (bank manager), unknown (seated), Frank Falconer, unknow

    Kansen voor warmte- en koudewinning uit drinkwater

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    Door te verwarmen en te koelen met drinkwaterhoeven we minder aardgas te verstoken en kunnen weklimaatverandering beperken. Maar is dat drinkwaterdaarna nog wel goed voor onze gezondheid? Bij de TUDelft en Waternet zochten ze het uit.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Sanitary Engineerin

    Bereiding van chloor uit zoutzuur

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    Document(en) uit de collectie Chemische ProcestechnologieDelftChemTechApplied Science

    Important tools for use by pediatric endocrinologists in the assessment of short stature

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    Assessment and management of children with growth failure has improved greatly over recent years. However, there remains a strong potential for further improvements by using novel digital techniques. A panel of experts discussed developments in digitalization of a number of important tools used by pediatric endocrinologists at the third 360 degrees European Meeting on Growth and Endocrine Disorders, funded by Merck KGaA, Germany, and this review is based on those discussions. It was reported that electronic monitoring and new algorithms have been devised that are providing more sensitive referral for short stature. In addition, computer programs have improved ways in which diagnoses are coded for use by various groups including healthcare providers and government health systems. Innovative cranial imaging techniques have been devised that are considered safer than using gadolinium contrast agents and are also more sensitive and accurate. Deep-learning neural networks are changing the way that bone age and bone health are assessed, which are more objective than standard methodologies. Models for prediction of growth response to growth hormone (GH) treatment are being improved by applying novel artificial intelligence methods that can identify non-linear and linear factors that relate to response, providing more accurate predictions. Determination and interpretation of insulin-like growth factor-1 (IGF-1) levels are becoming more standardized and consistent, for evaluation across different patient groups, and computer-learning models indicate that baseline IGF-1 standard deviation score is among the most important indicators of GH therapy response. While physicians involved in child growth and treatment of disorders resulting in growth failure need to be aware of, and keep abreast of, these latest developments, treatment decisions and management should continue to be based on clinical decisions. New digital technologies and advancements in the field should be aimed at improving clinical decisions, making greater standardization of assessment and facilitating patient-centered approaches.Developmen
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