327 research outputs found
CAP4KAM_nDOF: Computer-Assisted Proofs of existence of KAM tori in Hamiltonian systems with n (>=2) Degrees Of Freedom
No full textIn the folder you can produce by uncompressing the attached zippedfile (namely, that folder is called "CAP4KAM_nDOF"), you should findeverything you need in order to perform a complete computer-assistedproof of existence of invariant tori for a Hamiltonian that satifiesthree assumptions: (i) it describes a (Hamiltonian) system with n>=2 degrees of freedom and its canonical coordinates are n pairs of action-angle variables; (ii) it is close enough to a Kolmogorov normal form (so fulfilling also both the non-resonance and the non-degeneracy conditions usually adopted in the framework of KAM theory); (iii) its expansion in Taylor series (with respect to the actions) is finite, while its Fourier expansions (in the angles) can be infinite.The software included in the present folder "CAP4KAM_nDOF" is anextension of a first public release that was a sort of supplementarymaterial of the paper [VL], i.e.,Locatelli, Ugo (2021), “CAP4KAM2D: Computer-Assisted Proofs Fordemonstrating the existence of 2-Dimensional KAM tori”, MendeleyData, V1, doi: 10.17632/jdx22ysh2s.1The software included in the folder "CAP4KAM_nDOF" is designed tobe in a "easy-to-use" layout. Moreover, it is probably not too difficultto be modified for people expert in programming (in C).Everything about the files included in the folder "CAP4KAM_nDOF" iswidely described in the README.txt, that contains also carefulexplanations that should be useful for running the codes, monitoringthe results, modifying the input files, etc.Eventual corrections or remarks about the software package includedin the folder "CAP4KAM_nDOF" are more than welcome and can besent to the author (Ugo Locatelli) at the following e-mail address: [email protected]
Hematopoietic Stem Cell Transplantation in Thalassemia
No full textAlthough recent advances in gene therapy are expected to increase the chance of disease cure in thalassemia major, at present hematopoietic stem cell transplantation (HSCT) remains the only consolidated curative approach for this disorder. The widest experience has been obtained in the HLA-matched family donor (MFD) setting, with probabilities of overall and thalassemia-free survival exceeding 90% and 85%, respectively. As for most patients a suitable MFD is not available, alternative donors (HLA-matched unrelated donor, unrelated cord blood, HLA-haploidentical relative) have been increasingly explored, translating into the expansion of the number of patients treatable with HSCT
Jean Tardieu, père et artiste. Entretien avec Alix Turolla-Tardieu
No full textInterview of Alix Turolla-Tardieu, the daughter of the poet and author Jean Tardieu
UNITY-Locatelli Meeting Notes
No full textTyped document titled 'UNITY-Father Locatelli Meeting 4/14/89.' Document includes five numerical bullets with agenda items the include an introduction/welcome; history of UNITY; information regarding UNITY "today"; demands; and a session titled 'Open for discussion.' Documents features handwritten notes in black ink. Document does not specify author of agenda or notes
PERCHLORATES AS POWERFUL CATALYSTS IN MANY IMPORTANT ORGANIC TRANSFORMATIONS
No full textFor long times, metallic perchlorates have been considered dangerous compounds[1] in that they function as explosives and as incontrollable oxidizers.
Therefore, the fear of the great hazard connected with their manufacture and uses had prevented an extensive use both in research laboratories and in industrial processes.[2]
However, recently it has been cleared that this bad reputation is due to the mistaken association of metallic perchlorates with the oxidizing potential of perchloric acid and the pyrotechnic performances of NH4ClO4.
In this conference, we report that Magnesium and Zinc perchlorates can be used as powerful Lewis acids in several organic transformations which are commonly employed both in laboratory and industrial processes.
As depicted in the Scheme, perchlorates are able to promote a series of reactions such as:
a) Acylation of alcohols[3,4]
b) Fisher esterification[5]
c) Synthesis of b–enamino esters[6]
d) Protection of the amino group as N-Boc derivative[7]
Moreover, they can act as specific catalysts for the development of a new organic transformations. In fact, the treatment of an alcohol or a phenol with Boc2O in the presence of Mg(ClO4)2 leads to the unexpected formation of the corresponding t-butyl ethers.[8] This represents the first general method to synthesize aromatic t-butyl ethers.
In an analogous manner, the treatment of phenols with diethyl dicarbonate results in a very efficient method to produce difficulty available aryl ethyl carbonates.
Several of the above mentioned transformations can be carried out in the absence of the solvent, and often the catalyst can be easily recovered and reused without an appreciable loss of activity.
Acknowledgement
Work carried out in the framework of the National Project “Stereoselezione in Sintesi Organica. Metodologie e Applicazioni” supported by MIUR, Rome, by the University of Bologna, in the framework of “Progetto di Finanziamento Pluriennale, Ateneo di Bologna”, and by National project FIRB “Progettazione, preparazione e valutazione biologica e farmacologica di nuove molecole organiche quali potenziali farmaci”
References
[1] Schumacher, J. C. Perchlorates-Their Properties, Manufacture and Uses, ACS Monograph Series, Reinhold: New York, 1960.Author. Title[J]. Name of the journal, Year, Volume(Issue): initial page and ending page (Optional).
[2] Long, J. Chemical Health & Safety, 2002, 9, 12.
[3] Bartoli, G.; Bosco, M.; Dalpozzo, R.; Marcantoni, E.; Massaccesi, M.; Rinaldi, S.; Sambri, L. Synlett, 2003, 39.
[4] Bartoli, G.; Bosco, M.; Dalpozzo, R.; Marcantoni, E.; Massaccesi, M.; Sambri, L. Eur. J. Org. Chem. 2003, 4611.
[5] a) Gooβen, L.; Döhring, A. Adv. Synth. Catal. 2003, 345, 943; b) Bartoli, G.; Boeglin, J.; Bosco, M.; Locatelli, M.; Massaccesi, M.; Melchiorre, P.; Sambri, L. Adv. Synth. Catal. 2005, 347, 33.
[6] Bartoli, G.; Bosco, M.; Locatelli, M.; Marcantoni, E.; Melchiorre, P.; Sambri, L. Synlett 2004, 239.
[7] Bartoli, G.; Bosco, M.; Locatelli, M.; Marcantoni, E.; Massaccesi, M.; Melchiorre, P.; Sambri, L. Synlett 2004, 1794.
[8] Bartoli, G.; Bosco, M.; Locatelli, M.; Marcantoni, E.; Melchiorre, P.; Sambri, L. Org. Lett., 2004, 7, 427
PHARMACOKINETICS OF GEMCITABINE HYDROCHLORIDE AND IRINOTECAN HYDROCHLORIDE ALONE AND IN COMBINATION IN RAT PLASMA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-DIODE ARRAY DETECTOR
No full textThis communication reports an easy and quick HPLC-PDA method for the simultaneous analysis of Irinotecan Hydrochloride and Gemcitabine Hydrochloride in rat plasma samples both after single drug administration and drugs association. Gemcitabine Hydrochloride is commonly administered to treat non-small cell lung cancer (NSCLC), pancreatic adenocarcinoma, and in combination with paclitaxel for the treatment of breast cancer in the metastatic phase. Additionally Irinotecan Hydrochloride was used to treat colorectal cancer (CRC), gynecological cancers, carcinomas, non-small cell and small cell lung cancer. The drugs were detected simultaneously by using a Zorbax Extend C-18 column (250 mm × 4.6 mm; 5 m particle size) in gradient elution mode. The chromatographic analysis was performed in 15 minutes. The analytical method was calibrated and validated from 0.1 to 18 g/mL for both drugs. Rat plasma was used as biological samples during the analysis; while the 3-methylxanthine was used as internal standard. The performance of analytical method was further tested in rat plasma samples collected after single dose administration of drug or their association. Results demonstrated that HPLC-PDA method allows to detect the drugs in the range of concentrations herein reported and the analytical method is accurate and selective. The limit of quantification of the method was 0.1 g/mL. These values are similar or little higher to data published in literature, which are performed using sophisticated and expensive detectors such as mass spectrometer, and wich consider merely only one drug and not their association. The weighted-matrix matched standard curves showed a good linearity until 18 g/mL. The parallelism tests were also performed to evaluate if over-range samples can be analyzed after dilution, without affecting the performance of validated method. The intra- and inter-day precision (RSD%) values were ≤7.14% and ≤11.5%, respectively, for the full range of analysis. The intra- and inter-day trueness (Bias%) values ranged from -11.5% to 1.70% for the two drugs. At the best of our knowledge, this is the first HPLC-PDA method which allows to detect simultaneously Irinotecan Hydrochloride and Gemcitabine Hydrochloride in rat plasma, both after single and drugs association administration in order to evaluate how can interact and modify the pharmacokinetic parameters.
[1] M. Locatelli et. al. Simultaneous determination of Gemcitabine Hydrochloride and Irinotecan Hydrochloride in rat plasma by high performance liquid chromatography-diode array detector. J. Pharm. Biomed. Anal., Submitted (2018
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