827 research outputs found
The Metabolic Syndrome and the Membrane Content of Polyunsaturated Fatty Acids in Hypertensive Patients
No full textBackground: Polyunsaturated fatty acids (PUFA) have been reported to be beneficial on some components of the metabolic syndrome (MetS). We tested the hypothesis that in hypertensive patients, presence of MetS and its related components is associated with cell membrane content of PUFA, a measure that reflects the dietary intake of these fatty acids. Methods: In 55 consecutive patients with primary hypertension referred to our university center, we measured anthropometric variables, 24-hour ambulatory blood pressure, general biochemistries including plasma lipids, and the fatty acid composition of red blood cell (RBC) membrane by gas chromatography. Results: The prevalence of the MetS was 36.4% and in hypertensive patients with MetS, the RBC membrane content of total PUFA, PUFA of the n-6 family (n-6 PUFA), PUFA of the n-3 family (n-3 PUFA), polyunsaturated to saturated fatty acid ratio (PUFA/SFA), and omega-3 index was significantly lower than in patients without MetS. RBC membrane total PUFA, n-6 PUFA, n-3 PUFA, PUFA/SFA ratio, and omega-3 index were significantly and directly correlated with high-desity lipoprotein (HDL) cholesterol levels, a correlation that did not differ across tertiles of plasma apolipoprotein-A1. In multivariate linear regression analysis, HDL-cholesterol resulted to be directly and independently related to RBC membrane n-6 PUFA, PUFA/SFA ratio, and omega-3 index. Conversely, total cholesterol to HDL-cholesterol ratio had inverse and independent relationship with n-6 PUFA, PUFA/SFA ratio, and omega-3 index. Conclusions: In patients with hypertension the MetS is associated with lower cell membrane content of PUFA that is explained by a direct and independent relationship of membrane PUFA with HDL-cholesterol. This observation suggests reduced dietary intake of PUFA in these patients that might contribute to their cardiovascular risk
Comparison of BSIM3v2 and MOS MODEL 9
No full textThis report presents the results of parameter extraction for a 0.8#m CMOS process using a commercially available MOS model, BSIM3v2. A comparison of the performance of BSIM3v2 and the Philips model, MOS Model 9, is subsequently presented
Alcohol Intake More Than Doubles the Risk of Early Cardiovascular Events in Young Hypertensive Smokers
No full textAn interactive effect of tobacco and alcohol use has been described for cancer. Aim of this study was to investigate the joint effect of smoking and alcohol intake on major adverse cardiovascular and renal events (MACE) in young subjects screened for stage 1 hypertension
Office Pulse Pressure Is a Predictor of Favorable Outcome in Young- to Middle-Aged Subjects with Stage 1 Hypertension
No full text
The role of pulse pressure in young individuals remains controversial. The aim of the present study was to investigate the clinical significance of elevated pulse pressure in young- to middle-aged subjects screened for stage 1 hypertension. We examined 1241 subjects (mean age, 33.1±8.4 years) from the HARVEST (Hypertension Ambulatory Recording Venetia Study), during a median follow-up of 12.1 years. To evaluate the predictive value of pulse pressure and mean blood pressure for future hypertension needing treatment and for cardiovascular events, participants were grouped into pressure tertiles. Significant determinants of pulse pressure were male sex (
P
=0.029), younger age (
P
<0.001), physical activity (
P
=0.003), heart rate (
P
<0.001), systolic white-coat effect (
P
<0.001), and stroke volume (n=829;
P
<0.001). During follow-up, 65.1% of participants developed hypertension requiring pharmacological treatment and 5.1% experienced a cardiovascular event. Participants in the highest pulse pressure tertile had a reduced risk of incident hypertension compared with those of the bottom tertile (hazard ratio, 0.75; 95% confidence interval, 0.62–0.91;
P
=0.003). In contrast, participants in the top mean blood pressure tertile had an increase in risk (1.91; 1.57–2.33;
P
<0.001). In addition, participants in the highest pulse pressure tertile had a reduced risk of cardiovascular events (0.35; 0.17–0.73;
P
=0.005) and those in the top mean blood pressure tertile had an increase in risk (3.06; 1.32–7.09;
P
=0.009). Our data show that in subjects <45 years, only mean blood pressure is a predictor of adverse outcome whereas high pulse pressure even carries a reduced risk.
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Low night-time heart rate is longitudinally associated with lower augmentation index and central systolic blood pressure in hypertension
No full textSeveral studies have shown that the augmentation index (AIx) is negatively correlated with heart rate (HR). This led some authors to claim that the use of HR-lowering drugs may be detrimental in hypertension. The aim of this study was to assess the longitudinal and cross-sectional relationships of HR with AIx and central blood pressure (BP) in 346 subjects from the HARVEST (mean age 30.7 ± 8.5 years)
Investigating Laser-Induced Phase Engineering in MoS&#x2082; Transistors
No full textPhase engineering of MoS&#x2082; transistors has recently been demonstrated and has led to record low contact resistances. The phase patterning of MoS&#x2082; flakes with laser radiation has also been realized via spectroscopic methods, which invites the potential of controlling the metallic and semiconducting phases of MoS&#x2082; transistors by simple light exposure. Nevertheless, the fabrication and demonstration of laser-patterned MoS&#x2082; devices starting from the metallic polymorph have not been demonstrated yet. Here, we study the effects of laser radiation on 1T/1T&#x2032;-MoS₂ transistors with the prospect of driving an in situ phase transition to the 2H-polymorph through light exposure. We find that although the Raman peaks of 2H-MoS₂ become more prominent and the ones from the 1T/1T&#x2032; phase fade after the laser exposure, the semiconducting properties of the laser-patterned devices are not fully restored, and the laser treatment ultimately leads to the degradation of the transport channel.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.QN/Steele LabQN/van der Zant La
A3205 Different role of elevated pulse pressure according to gender in a cohort of young to middle age stage I hypertensives
No full textHypertension, pulse pressure, gender, young to middle age, stage I hypertensio
Dipping pattern and short-term blood pressure variability are stronger predictors of cardiovascular events than average 24-hour blood pressure in young hypertensive subjects
No full textAims The role of increased blood pressure (BP) variability and a blunted day-night BP drop is still being debated, particularly in young hypertensive subjects. We investigated the contribution of BP variability and day-night BP changes combined to cardiovascular events in initially untreated young hypertensive individuals. Methods and results We selected 1794 subjects aged <= 45 years from the HARVEST and the PIUMA studies, two long-term observational studies in subjects with hypertension. The outcome was a composite pool of non-fatal myocardial infarction or stroke, heart failure needing hospitalization, death from cardiovascular causes, and myocardial or limb revascularization procedures. During an 11.3-year follow-up, 140 cardiovascular events were accrued. A multivariable Cox model which included BP variability and non-dipping was more informative (Akaike Information Criterion = 1536.9) than the model which included average of 24-h BP (Akaike Information Criterion = 1553.6). A higher hazard ratio (HR) was observed for non-dipping [HR 2.22; 95% confidence interval (CI): 1.55-3.17; P < 0.0001] and for high BP variability (HR 1.84; 95% CI: 1.26-2.65; P = 0.0015) than for high average 24-h BP (HR 1.58; 95% CI: 1.07-2.33; P = 0.020). When average 24-h ambulatory BP was included in a nested model, the -2log likelihood decreased from 1524.9 to 1519.3, and there was a tendency for an interactive effect between 24-h BP and non-dipping on risk of cardiovascular events (P = 0.092). Conclusion In young hypertensive individuals, prognostic models including BP variability and non-dipping pattern provide better information than models with average 24-h ambulatory BP alone. More consideration should be given to BP variability and the day-night BP pattern beyond the average 24-h ambulatory BP in young hypertensive subjects
Clinical characteristics and risk of hypertension needing treatment in young patients with systolic hypertension identified with ambulatory monitoring
No full textThe clinical significance of isolated systolic hypertension (ISH) in youth is controversial. One main confounding factor is the strong white-coat effect often observed in ISH patients. The aim of this study was to investigate the risk of hypertension needing pharmacological treatment in ISH identified with ambulatory 24-h blood pressure (24-h BP)
Coffee consumption and risk of cardiovascular events in hypertensive patients. Results from the HARVEST
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