1,721,019 research outputs found
Le reazioni avverse al cibo e l'apparato gastrointestinale: quadri clinici, iter diagnostico e gestione terapeutica
No full textEvaluation of the cardiac toxicity of N-methyl-glucamine antimoniate in dogs with naturally occurring leishmaniasis
No full textThe aim of this study was to evaluate the cardiotoxic effects of pentavalent antimonial compounds in dogs with leishmaniasis. Twenty-eight dogs with clinical disease due to natural infection with Leishmania infantum were treated with 75 mg/kg meglumine antimoniate SC every 12h for 60 days. Serum cardiac troponin I (cTnI) concentrations were determined and routine and 24h ambulatory electrocardiographic monitoring was performed before the onset (T0) and at the end of treatment (T60). No abnormalities were found in routine and 24h electrocardiographic tracings before and after treatment. No statistical difference was found between serum cTnI concentrations or corrected QT intervals at T0 and T60. There was no evidence of laboratory or electrocardiographic features of cardiac toxicity in dogs with leishmaniasis treated with a therapeutic dose of meglumine antimoniate for 60 days
Evaluation of the Cardiac Toxicity of N-Methyl-Glucamine in Leishmaniotic dogs
No full textN-methyl-glucamine (Glucantime®) is a first line drug used in anti-leishmania treatment. Several side-effects, including cardiac negative effects, have been described in patients treated with this drug. In particular, prolongation of the QT interval, ventricular arrhythmias and sudden death have been reported in humans. The aim of this study was to assess the possible negative cardiac effects of N-methyl-glucamine in dogs with spontaneous Leishmaniosis.
Thirteen dogs naturally affected by Leishmaniosis were treated with Glucantime® at a dose of 75 mg/kg q12 h SC for 60 days. On each dog, evaluation of serum cardiac troponin I (cTnI) concentration was carried out using an automated immunoassay method before the onset of the therapy (T0) and at the end of treatment (T60). Furthermore, 24-hour ambulatory electrocardiographic (ECG) monitoring was performed at the same time interval and the QT interval corrected for heart rate (QTc) was calculated using a one-parameter logarithmic formula. Serum cTnI concentration and QTc values at T0 and T60 were compared using a Mann-Whitney u-test and a paired Student’s t-test, respectively. A value of P<0,05 was considered to be significant.
Serum cTnI concentrations were normal either before and at the end of the study and no statistical differences were observed from T0 and T60. No cardiac arrhythmia was found in 24-hour ECG tracings before and after the treatment. Analysis of QTc values did not evidenced any statistical difference from T0 and T60.
Results of the present study evidenced no laboratory and electrocardiographic features of cardiac toxicity in Leishmaniotic dogs treated with a therapeutic dose of N-methyl-glucamine for 60 days
Evaluation of serum enzyme activities as predictors of passive transfer status in lambs
No full textObjective-To determine the associations between serum IgG concentration and serum activities of gamma-glutamyltransferase (GGT), alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and pseudocholinesterase for the potential use of these serum enzymes as predictors of passive transfer status in neonatal lambs. Design-Prospective observational study. Animals-47 Sardinian lambs from birth to 2 days old. Procedure-Serum enzyme activities were measured by use of commercially available kits and a clinical biochemical analyzer. Serum IgG concentration was determined by single radial immunodiffusion. Associations between serum IgG concentration and the activity of each serum enzyme were established by use of regression analysis. Results-A significant correlation was detected between serum IgG concentration and serum GGT activity in 1- and 2-day-old lambs. Minimal correlations were detected between serum IgG concentration and serum alkaline phosphatase activity in 1-day-old lambs and serum pseudocholinesterase activity in 1- and 2-day-old lambs. No significant associations were detected between serum IgG concentration and serum activities of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. A multiple linear regression model was accurate for the estimation of the natural logarithm of serum IgG concentration as a function of the natural logarithm of serum GGT activity and of the age of lambs at the time of sampling (adjusted R-2 = 0.89). This model was then used to calculate the serum GGT activity equivalent to various serum IgG concentrations for 1- and 2-day-old lambs. Conclusions and Clinical Relevance-Results suggested that passive transfer status in neonatal lambs can be successfully predicted by measurement of serum GGT activity but not by measurement of the other enzymes tested.[...
Estensione al seno mascellare di un carcinoma squamocellulare della terza palpebra in un cavallo
No full textIl carcinoma a cellule squamose (SCC) è descritto come una delle neoplasie epiteliali primarie più frequenti e invasive dell'occhio e dei suoi annessi, e dei seni mascellari. Qui di seguito si descrive il caso clinico di un soggetto adulto portato a visita per tumefazione della regione oculare e zigomatica sinistra, con precedente anamnesi di asportazione della terza palpebra per presenza di una neoformazione rotondeggiante del diametro di circa un centimetro. In seguito alla diagnosi di carcinoma a cellule squamose infiltrante il seno mascellare e della notevole compromissione delle strutture coinvolte, il soggetto è stato sottoposto ad eutanasia senza ricorrere ad alcun trattamento terapeutic
Feline leishmaniasis and ehrlichiosis: serological investigation in Abruzzo region
No full textThe prevalence of leishmaniasis and ehrlichiosis has rarely been reported in the feline medicine. The purpose of this report was to performe a sero-epidemiological study in cats living in Abruzzo region. Two hundred and three feline serum samples were investigated for the detection of anti-Leishmania infantum and anti-Ehrlichia canis antibodies using indirect immunofluorescence test. The seroprevalence was 16,2% for Leishmania, with titers ranging from 1: 40 to 1:320, and 1% for Ehrlichia, with titers of 1:160 and 1:2560. Co-infection by immunosuppressive viruses (FIV and FeLV) was also investigated in seropositive cats to evaluate the possible role of these agents in triggering the infection of Leishmania and Ehrlichia in cats.[...
Attività dell’enzima gamma-glutamiltransferasi nel latte di pecore sane e con mastite subclinica
No full textRilievi clinici e diagnostici collaterali in 7 cani con tumori della base del cuore
No full textThe clinical and diagnostic imaging findings of 7 dogs with echocardiographically diagnosed heart base tumors (HBTs) are described. Signalment, physical examination, thoracic radiography and echocardiography were obtained. In 4 cases HBTs were associated with clinical signs of congestive heart failure. In the remaining 3 cases, HBT was an incidental finding during echocardiographic examination of dogs with chronic valvular disease. In one case, with pathological diagnosis of aortic carcinoma, neoplastic invasion of both atria was observed on echocardiography. The main radiographic finding suggestive of HBT was dorsal and right lateral tracheal displacement
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