219 research outputs found
Microwave medical imaging: potentialities and limitations of a stochastic optimization technique
No full textMicrowave medical imaging: Potentialities and limitations of a stochastic optimization technique
Author(s): Caorsi, S (Caorsi, S); Massa, A (Massa, A); Pastorino, M (Pastorino, M); Rosani, A (Rosani, A)
Source: IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES Volume: 52 Issue: 8 Pages: 1909-1916 DOI: 10.1109/tmtt.2004.832016 Part: Part 2 Published: AUG 2004
Times Cited: 14 (from Web of Science)
Cited References: 29 [ view related records ] Citation Map
Abstract: An approach based on a stochastic optimization technique is proposed for medical microwave imaging. The approach is based on the integral equations of the electromagnetic inverse scattering. After discretization of the continuous model, the problem solution is recast as a global optimization problem. A functional is constructed on the basis of a Markov random field model and minimized by a genetic algorithm. In order to reduce the computational load, a model of the cross section of the biological body is considered. In this way, the investigation area is limited by separating the scattering contribution of a fixed region under test from those of other parts of the model. Some preliminary results concerning a two-dimensional model of a human thorax are reported. Such a biological structure is inspected by the proposed tomographic approach in order to detect and localize the presence of an "object" modeling a tumor.
Accession Number: WOS:000223051400007
Document Type: Article
Language: English
Author Keywords: genetic algorithms (GAs); inverse scattering; medical imaging; microwave imaging; optimization problems
KeyWords Plus: BREAST-CANCER DETECTION; GENETIC ALGORITHMS; ELECTROMAGNETICS; TISSUES; MODEL
Reprint Address: Rosani, A (reprint author), Univ Pavia, Dept Elect, I-27100 Pavia, Italy
Addresses:
1. Univ Pavia, Dept Elect, I-27100 Pavia, Italy
2. Univ Trent, Dept Informat & Commun Technol, I-38050 Trent, Italy
3. Univ Genoa, Dept Biophys & Elect Engn, I-16145 Genoa, Italy
E-mail Address: [email protected], [email protected], [email protected]
Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 445 HOES LANE, PISCATAWAY, NJ 08855 USA
Web of Science Category: Engineering, Electrical & Electronic
Subject Category: Engineering
IDS Number: 843BW
ISSN: 0018-948
Pancreatic Cancer: From Genetic Mechanisms to Translational Challenges
No full textPancreatic ductal adenocarcinoma (PDAC), one of the most aggressive malignancies in industrialized countries, is predicted to become the second leading cause of cancer deaths by 2040 [...
Las formas de la naturaleza y sus formas de regulación
No full textActas del Cuarto Curso del Ciclo de Cursos de Postgrado sobre Derecho Agrario y Ambiental Internacional, dirigido por el Dr. Leonardo Fabio Pastorino (Res. 61/06 del HCA), dedicado a: Las formas de la naturaleza y sus formas de regulación y de la Jornada Internacional CUIA-UNLP sobre Recursos Hídricos: entre bienes comunes, transformación y participación bajo la responsabilidad científica de los profesores Lorenza Paoloni y María Laura Carranza (Università di Udine) y Leonardo Fabio Pastorino (Universidad Nacional de La Plata). Actividades realizadas en la semana del 7 al 11 de mayo de 2018 en el marco del Proyecto de Investigación “Derecho agrario, ambiental y del agua: respuestas en tiempos de cambio”, dirigido por el Dr. Leonardo Fabio Pastorino y codirigido por la Dra. María de las Nieves Cenicacelaya.4º Curso del Ciclo de Cursos de Posgrado sobre Derecho Agrario y Ambiental Internacional y Jornada Internacional CUIA-UNLP sobre Recursos Hídricos: Entre bienes comunes, transformación y participación.Facultad de Ciencias Jurídicas y Sociale
Optimization of difference patterns for monopulse antennas by a hybrid real/integer-coded differential evolution method
No full textOptimization of the difference patterns for monopulse antennas by a hybrid real/integer-coded differential evolution method
Author(s): Caorsi, S (Caorsi, S); Massa, A (Massa, A); Pastorino, M (Pastorino, M); Randazzo, A (Randazzo, A)
Source: IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION Volume: 53 Issue: 1 Pages: 372-376 DOI: 10.1109/TAP.2004.838788 Part: Part 2 Published: JAN 2005
Times Cited: 46 (from Web of Science)
Cited References: 9 [ view related records ] Citation Map
Abstract: The optimization of difference patterns of monopulse antennas is considered. The synthesis problem is recast as an optimization problem by defining a suitable cost function. In particular, in this paper, the cost function is based on constraints on the side-lobe levels. A subarray configuration is adopted and the excitations of the difference pattern are approximately determined. The optimization problem isefficiently solved by a differential evolution algorithm, which is able to contemporarily handle real and integer unknowns. Numerical results are reported concerning classical array configurations previously considered in the literature.
Accession Number: WOS:000226261600014
Document Type: Article
Language: English
Author Keywords: array antennas; evolutionary algorithm; monopulse antennas; sum and difference patterns
KeyWords Plus: SUM; ARRAYS
Reprint Address: Caorsi, S (reprint author), Univ Pavia, Dept Elect, Via Palestro 3, I-27100 Pavia, Italy
Addresses:
1. Univ Pavia, Dept Elect, I-27100 Pavia, Italy
E-mail Address: [email protected]
Publisher: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
Web of Science Category: Engineering, Electrical & Electronic; Telecommunications
Subject Category: Engineering; Telecommunications
IDS Number: 886VT
ISSN: 0018-926
Germline POT1 Variants: A Critical Perspective on POT1 Tumor Predisposition Syndrome
No full textThe Protection of Telomere 1 (POT1) gene was identified as a melanoma predisposition candidate nearly 10 years ago. Thereafter, various cancers have been proposed as associated with germline POT1 variants in the context of the so-called POT1 Predisposition Tumor Syndrome (POT1–TPD). While the key role, and related risks, of the alterations in POT1 in melanoma are established, the correlation between germline POT1 variants and the susceptibility to other cancers partially lacks evidence, due also to the rarity of POT1–TPD. Issues range from the absence of functional or segregation studies to biased datasets or the need for a revised classification of variants. Furthermore, a proposal of a surveillance protocol related to the cancers associated with POT1 pathogenic variants requires reliable data to avoid an excessive, possibly unjustified, burden for POT1 variant carriers. We propose a critical perspective regarding data published over the last 10 years that correlate POT1 variants to various types of cancer, other than cutaneous melanoma, to offer food for thought for the specialists who manage cancer predisposition syndromes and to stimulate a debate on the grey areas that have been exposed
Hyperbranched PDLA-polyglicerol: A novel additive for tuning PLLA electrospun fiber degradation and properties
No full textIn this paper, it was developed the synthesis of a novel polymer additive potentially capable of modifying the features of electrospun fibers based on poly(L-lactide) (PLLA). Indeed, the above molecule, which was designed by taking into account both the features of the polymer matrix and the specific applications of the final material, was made up of a high-molecular-mass hyperbranched polyglicerol (HBPG) core and poly(D-lactide) (PDLA) arms (HBPG-PDLA). 1H NMR characterization allowed to assess the successful preparation of the dendritic HBPG-PDLA, synthesized by means of ring opening polymerization (ROP) of D-lactide, as well as the number average molecular weight per arm, that is about 1100 g/mol. Moreover, by combining 1H NMR and TGA results, it was determined an average number of polylactide arms of about 300. Electrospun fibers based on PLLA and HBPG-PDLA were prepared by directly adding the as-synthesized dendritic additive into the electrospinning solution to a final concentration of ca. 25 wt.%. FE-SEM analysis of the system, prepared by applying the optimized electrospinning conditions, demonstrated the formation of defect-free fibers without separated, micrometric domains of the additive. The thermal properties of both neat PLLA and composite fibers were studied by DSC analysis. The partial stereocomplexation of the systems containing HBPG-PDLA, resulting from the combination of the PDLA arms of the dendritic polymer with the chains of PLLA, was confirmed by calorimetric measurements as well as by X-ray diffraction analysis. The dendritic additive, featuring the hyperbranched polyglycerol core, was found to enhance the hydrophilicity of the fibers and consequently their enzymatic degradation rate, which turned out to be much higher than that of the neat PLLA fibers. Unlike the organic additives usually applied to modify the properties of PLLA, the addition of HBPG-PDLA to the fibers was also found to lead to an increase of the mechanical properties of the composite systems, that is an increment of their Young's modulus
De la concepción liberal de la propiedad privada inmueble, a la función social y a la función ecológica
No full textEste trabajo presenta la evolución conceptual que tuvo el derecho de propiedad. En primer lugar se rememoran los orígenes a fines del Siglo XVIII del derecho de propiedad como derecho natural y el desarrollo de un concepto de derecho individual, absoluto, perpetuo. En segundo lugar se analiza cómo surgió la primera limitación a esa concepción bajo la fórmula de la función social. Respecto a esta última, el trabajo muestra que no se trata tampoco de un concepto unívoco. En una presentación original del autor se clasifican diversas concepciones en tres grandes opciones que pueden distinguirse por claros efectos o alcances jurídicos diferentes. Finalmente, se plantea la función ecológica de la propiedad como una función aún no claramente definida en forma universal ni normativa y, con reflejo a las tres posturas definidas para la función social de la propiedad, se trata de delinear el alcance que va adquiriendo o puede alcanzar la función ecológica de la propiedad.This paper presents the conceptual evolution of property rights. In first place, it thinks back to the origins of property right as a natural right and the development of the concept as an individual, absolute and perpetual right at the end of 18th century. In second place, it analyses how the first limitation to this conception arose under the formulation of the social function. In the latter respect, this paper shows it is not a univocal concept either. Doing an original presentation, the author classifies different conceptions into three major options that can be distinguished by clear effects or different legal scopes. Finally, the ecological function of property is considered as a function not yet clearly defined in an universal or normative way, and, reflecting those three positions defined for the social function of property, it is about delineating the scope that it is acquiring or can reach the ecological function of the property.Universidad Nacional de La Plata (UNLP) - Facultad de Ciencias Jurídicas y Sociale
Wyrok Najwyższego Trybunału Sprawiedliwości Narodu Argentyńskiego z 29 grudnia 2015 r. w sprawie C. C. 1442, L. XLVIII – Komisja Regulacyjna Kwalifikowanej Nazwy Pochodzenia „La Rioja” i inni przeciwko Narodowemu Instytutowi Uprawy Winorośli
No full textThe article presents the international normative framework for geographical indications that includes the case of homonymy. In the case of Rioja wine, and at the time of the TRIPS Agreement, this problem was discussed in relation to the production of wines in the province of La Rioja Argentina. In 2003, this author addressed the issue and, subsequently, the Rioja Qualified Origin Regulatory Board presented a first administrative and judicial case later in Argentina. This article gives an account of the case and how the Argentine Justice resolved the issue
Varianti polimorfiche del gene MC1R (melanocortin receptor 1): Analisi in pazienti Liguri affetti da melanoma e negativi per mutazioni nei geni CDKN2A e CDK4
No full textAbsence of high risk gene mutations in hereditary melanoma points to the interplay between somatic and low risk germline variants
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