1,721,068 research outputs found
Mucoadhesive nanoparticles of Eudragit RS 100/cyclodextrin intended for transmucosal routes for peptides
No full textComparative study among some potential dermal formulations intended for glutathione administration
No full textRecent Advances in Nanodrug Delivery Systems Production, Efficacy, Safety, and Toxicity
No full textIn the last three decades, the development of nanoparticles or nano-formulations as drug delivery systems has emerged as a promising tool to overcome the limitations of conventional delivery, potentially to improve the stability and solubility of active molecules, promote their transport across the biological membranes, and prolong circulation times to increase efficacy of a therapy. Despite several nano-formulations having applications in drug delivery, some issues concerning their safety and toxicity are still debated. This chapter describes the recent available information regarding safety, toxicity, and efficacy of nano-formulations for drug delivery. Several key factors can influence the behavior of nanoparticles in a biological environment, and their evaluation is crucial to design non-toxic and effective nano-formulations. Among them, we have focused our attention on materials and methods for their preparation (including the innovative microfluidic technique), mechanisms of interactions with biological systems, purification of nanoparticles, manufacture impurities, and nano-stability. This chapter places emphasis on the utilization of in silico, in vitro, and in vivo models for the assessment and prediction of toxicity associated with these nano-formulations. Furthermore, the chapter includes specific examples of in vitro and in vivo studies conducted on nanoparticles, illustrating their application in this field
SPRAY DRIED MICROPARTICLES OF CHITOSAN OR ITS THIOLIC DERIVATES FOR CELECOXIB INTRAVESCICAL DELIVERY
No full textSYNTHESIS, CHARACTERIZATION AND CELLULAR INTERNALIZATION OF TSPO TARGETED G(4)-PAMAM DENDRIMERS INTO C6 RAT GLIOMA CELLS.
No full textCombined Eudragit RS100 cyclodextrin nanoparticles intended for transmucosal administration of Glutathione
No full textCombined Chitosan-Cyclodextrin Nanoparticles: A Potential Carrier For The Transmucosal Administration Of Glutathione
No full textNew nanostructured self-assemblong inulin-a-tocopherol bioconjugates for biomedical applications
No full textNew conjugates between inulin (INU) and vitamin E (VITE) able to form amphiphilic systems self-assembling in nanostructures thought for biomedical applications such as the therapy of urinary tract affections were prepared.
This work, shows the syntheses, characterization and self-assembling properties of the obtained polymeric conjugates (INVITE).
The reaction between VITE and INU has been carried out in bulk, without isolation of intermediate products leading to a convenient one-step reaction. To tailor the physical-chemical characteristics of the INVITE bioconjugate, six different INVITE conjugates were obtained by varying the relative amount of bonded VITE respect to INU repeating units.
The obtained products were characterized by 1H-NMR, 13C-NMR, FT-IR and DSC. Furthermore, to verify that VITE does not undergo any oxidation during the reactions, UV-VIS analyses have been performed and the ability of the new conjugates to form nanoparticulate systems in water or 0.9 % saline was performed by dynamic light scattering. Furthermore, in the same media, was evaluated the stability of the INVITE nanosystems after incubation at 25 °C up to 12 days, by measuring at different time points their size variation. The degree of derivatization was found not influenced by the temperature, but it mostly depend from the different molar ratios. Interestingly, the introduction of VITE in the inulin backbone resulted almost quantitative.
All conjugates resulted self-assembling in water forming nanosystems sized below 100 nm. The nanosystems are stable and do not aggregate after 12 days incubation. These results strongly encourage to prove these systems for drug delivery applications
Brain microdialysis as a valuable tool for elucidating the behaviour of potential prodrugs acting at CNS level: application to two alpidem analogues
No full textPrediction of solubility enhancement for drugs in concentrated aqueous solutions of 2-hydroxypropyl-β-cyclodextrin using multivariate regression analysis
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