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The effects of thymoxamine on guinea pig ileum contractions
No full textThe effects of thymoxamine on the contractions induced in guinea pig isolated ileum were examined. The drug was tested in a large range of concentrations (10-8-10-4 M). The twitch response induced by acetylcholine was potentiated by low concentrations and inhibited by high concentrations of the α-blocking drug thymoxamine. The contractions in response to carbachol were always inhibited. Thymoxamine also affected the responses of the ileum to other stimulants: angiotensin, pentagastrin, cholecystokinin. The drug (8 x 10-5, 5 x 10-4 M) inhibited the calcium contraction of high K+ depolarized preparation
EFFETTI DEL DANTROLENE SODICO SUL MUSCOLO DETRUSORE DI VESCICA URINARIA ISOLATA DI CAVIA
No full textINFLUENCE OF pH ON THE RESPONSES OF GUINEA-PIG ISOLATED TRACHEA TO SYMPATHOMIMETIC AMINES
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Functional and binding studies on dopamine D1 receptors in districts controlling intraocular pressure.
No full textEFFETTI STIMOLANTI DA DANTROLENE SODICO SU ORGANI E MUSCOLATURA LISCIA.
No full textThe effects of sodium dantrolene (DaNa), a calcium antagonist specifically acting on skeletal muscles, were evaluated on the spontaneous contractions of ileum, uterine horns and longitudinal strips of esophageal smooth muscle, in vitro. DaNa (1.81 to 15 μg/ml) caused a reversible dose-related increase of the spontaneous contractions of the three organs. DaNa (15 μg/ml) caused a 60±3% increase of the ileum spontaneous tone, and caused a 57±3% increase in the frequency of the spontaneous contractions of the uterus. The stimulatory effect of DaNa on the uterine musculature was not antagonized by atropine, methysergide or indomethacin. In the esophagus the maximum increase of the spontaneous tone and contractions (65±2%) was due to 3.7 μg/ml perfusion of DaNa. This effect was antagonized by nifedipin
Evidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitization.
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DANTROLENE SODIUM: STIMULATORY AD DEPRESSANT EFFECTS ON THE CONTRACTILITY OF GUINEA-PIG UTERUS IN VITRO.
No full textThe effects of dantrolene sodium on the spontaneous and oxytocin-induced contractions of guinea-pig uterus were studied in vitro. Dantrolene reversibly increased the spontaneous contraction frequency of guinea-pig uterus. The effect was not dose-related and was not antagonized by atropine, methysergide or indomethacin. Dantrolene dose dependently and reversibly reduced the contractile responses of guinea-pig uterus to oxytocin. The varying effects of dantrolene on the uterus probably involve inhibition of calcium movement at more than one site of the muscl
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia
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