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La RM cardiaca
No full textLa risonanza magnetica è un utile strumento di indagine in medicina cardiovascolare
e offre l’opportunità di associare un’elevata accuratezza diagnostica alla corretta stratificazione
prognostica dei pazienti. Nella cardiologia dello sport trova attualmente
largo impiego, sia grazie ai notevoli progressi tecnologici sia per la necessità sempre
più stringente di identificare soggetti apparentemente sani ma portatori di cardiopatie
ad elevato rischio di vita durante l’esercizio fisico. Tramite determinate sequenze di
analisi è possibile studiare la morfologia e la funzione globale e regionale del cuore,
identificare processi infiammatori acuti e cronici, aree di edema e di necrosi miocardica.
Inoltre, la possibilità di effettuare una caratterizzazione tissutale del cuore permette
di formulare, in modo non invasivo, una diagnosi certa di particolari miocardiopatie.
La risonanza magnetica cardiaca può essere ripetuta nel tempo per verificare la
risposta a specifiche terapie o monitorare l’andamento di determinati processi patologici:
i costi relativi alla gestione delle apparecchiature vengono così controbilanciati
dall’enorme potenzialità e beneficio nel management clinico dei pazienti
The bubble heart'. an unusual natural history told by multimodality imaging- a case report
Full text linkBackground Intracardiac thrombosis is a relatively common pathological condition. Often, it is diagnosed at echocardiography during the subacute or chronic phase. In the very acute phase, tissue composition can make thrombus appearance very different from that usually seen. Fresh thrombosis has been previously found also in peripartum cardiomyopathy (PPC), but with imaging features different from our case.
Case summary A 27-year-old woman was referred to our hospital for PPC, with echocardiographic finding of intraventricular masses, resembling big bubbles. Cardiac magnetic resonance (CMR) allowed definitively diagnosing intracardiac 'very acute' thrombosis, which is rarely detected.
Discussion Our case provides a practical lesson about management of an unusual presentation of a common problem. When early echocardiography does not allow making a certain diagnosis, CMR can be helpful and decisive, due to its unique ability to provide characterization of intracardiac masses
Dna-dependent dna polymerase species in male germ cells of the mouse.
No full textQuasi-homogeneous fractions of male mouse germ cells at definite stages of meiosis and spermiogenesis were obtained by using a separation method based on sedimentation velocity in an albumin gradient. In the various cell types, the total DNA-dependent DNA polymerase activity was determined, and the major enzymatic forms were characterized. The DNA polymerase species present in premeiotic, meiotic and post-meiotic cells were analyzed by glycerol gradient sedimentation. Two types of DNA polymerase were identified in fractions enriched in spermatogonia and preleptotene spermatocytes. One showed a sedimentation coefficient of about 7.5 S and was sensitive to N-ethylmaleimide (NEM); the other exhibited a sedimentation coefficient between 3 and 4 S and was resistant to NEM. On the basis of their sedimentation coefficients, their sensitivity to NEM and their template specificities, these 2 enzymes were identified respectively as alpha and beta DNA polymerases as reported in mammals. The gradient analysis performed on fractions enriched in meiotic and post-meiotic cells revealed the presence of DNA polymerase beta only. A quantitative analysis showed that the activity of the DNA polymerase beta reaches a maximum at middle-late pachytene stage and then drops gradually during spermiogenesis. Although any conclusion as to the biological role of this high level of DNA polymerase activity in pachytene spermatocytes is premature, it is tempting to suggest that this enzyme is involved in meiotic recombination
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