1,721,079 research outputs found
Fototerapia e fotochemioterapia: un lungo cammino cominciato 4000 anni fa.
No full textThe aim of this review was to trace the main steps of phototherapy and photochemotherapy through history. Although the therapeutic effects of sunlight, either alone or in combination with the use of natural photosensitizing substances, were well known by the ancient Indians and Egyptians in 2000 B.C., only during this century have studies been carried out allowing a scientific approach to this important field of dermatology. The Authors have reviewed the literature to trace historically the biochemistry of furocumarins, the development of irradiative sources, the first dermatologic clinical applications of non-ionizing radiation up to the birth, about 20 years ago, of modern photodermatology
Fototerapia e fotochemioterapia: un lungo cammino cominciato 4000 anni fa.
No full textThe aim of this review was to trace the main steps of phototherapy and photochemotherapy through history. Although the therapeutic effects of sunlight, either alone or in combination with the use of natural photosensitizing substances, were well known by the ancient Indians and Egyptians in 2000 B.C., only during this century have studies been carried out allowing a scientific approach to this important field of dermatology. The Authors have reviewed the literature to trace historically the biochemistry of furocumarins, the development of irradiative sources, the first dermatologic clinical applications of non-ionizing radiation up to the birth, about 20 years ago, of modern photodermatology
Clinical evaluation of an association of dexametasone acetate, clotrimazole and azidoamphenicol for topical use, a controlled study
No full text
Palladium Supported on Silk Fibroin for Suzuki–Miyaura Cross-Coupling Reactions
No full textSilk fibroin supported Pd (Pd/SF) has been prepared and used as catalyst in Suzuki–Miyaura cross-coupling reactions in water/ethanol (4:1 v/v) mixture. The reactions proceed rapidly with aryl iodides and boronic acids with different electronic properties using low metal loading (0.38 mol-%). Pd/SF exhibits better recyclability compared to other biopolymer-supported Pd catalysts, up to nineteen cycles without loss of activity
Identification of a prognostic gene signature associated with MBP-1 expression in ErbB2-negative breast carcinomas
No full textThe ENO1 transcript, which encodes the glycolitic enzyme alpha-enolase, can be translated into a shorter nuclear protein called Myc-promoter Binding Protein-1 (MBP-1) by using an alternative translation start site. MBP-1 acts as a negative regulator of c-Myc, ErbB2 and Cox2 genes (1). Several evidences indicate that MBP-1 acts as a tumor suppressor in breast carcinoma and prostate cancer and its expression results in a reduced invasive ability (2). In our previous studies, we showed that MBP-1 is expressed and easily detectable in normal breast epithelial cells, but a loss of expression occurs in most primary invasive ductal carcinomas (IDC) of the breast. Furthermore, in these tumors MBP-1 expression inversely correlated with the expression levels of the ErbB2 and Ki67 proteins (3).
In order to better understand the role of MBP-1 in breast cancer and to correlate its expression to a gene signature with prognostic value, we evaluated the expression of approximately 21,000 genes in primary breast carcinoma by using the Agilent microarray technology. A comparison of the gene expression profiles obtained from MBP-1+ve and MBP-1-ve ErbB2-negative IDCs led to the identification of differentially expressed (DE) genes that may underlie the different clinical behaviors of these two subtypes of breast carcinoma. Owing to the prognostic influence of nuclear MBP-1 expression in a subgroup of tumors from patients with node-negative and ErbB2-negative carcinomas, the combination of immunohistochemical analyses of MBP-1 and proteins encoded by genes we found DE by expression profiling, may prove to be a clinically valuable prognostic variable for breast cancer patients
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