102,710 research outputs found
The influence of the type of dry-cured Italian PDO ham on cathepsin B activity trend during processing
No full textCathepsin B activity was measured during processing in hams originating from the main Italian prosciutto PDOs: Parma, San Daniele and Toscano. Sixty-five heavy pig thighs, from sixty-five Italian large white x Italian Landrace pigs bred and slaughtered in the same conditions were considered. Five thighs represented the post-mortem control time. The other 60 were distributed one plant per PDO, following a balanced plan. The thighs were sampled at the biceps femoris in groups of four per plant in the following ripening phases: salting, resting, drying, greasing, end of curing. The activity of the Cathepsin B (U/g protein) was determined by means of fluorescence measurements. The Cathepsin B ripening trend of the various PDOs was significantly different, particularly during the initial and mid-curing stage. This activity correlates with the proteolysis index through a PDO dependent pattern, indicating that different processing conditions can influence the quality of prosciutto, since they determine its biochemical development
Ende oder Wende der Lehrerbildung? Bericht über das Bildungspolitische Seminar der Pädagogischen Hochschule Westfalen-Lippe am 1. und 2. Juli 1977 im Zentrum für Interdisziplinäre Forschung der Universität Bielefeld
No full textBorchard G, Radkau J, Schuberth E. Ende oder Wende der Lehrerbildung? Bericht über das Bildungspolitische Seminar der Pädagogischen Hochschule Westfalen-Lippe am 1. und 2. Juli 1977 im Zentrum für Interdisziplinäre Forschung der Universität Bielefeld. Bielefeld: Pädag. Hochsch. Westfalen-Lippe, Abt. Bielefeld; 1977
An die Bewohner hiesiger Stadt
No full text[Pauline C. W. F. z. Lippe g. P. z. Anhalt]In FrakturVorläufiger Rechenschaftsbericht über das Armenwesen in Detmol
OSCP subunit of mitochondrial ATP synthase: role in regulation of enzyme function and of its transition to a pore.
No full textThe permeability transition pore (PTP) is a latent, high-conductance channel of the inner mitochondrial membrane. When
activated, it plays a key role in cell death and therefore in several diseases. The investigation of the PTP took an unexpected turn
after the discovery that cyclophilin D (the target of the PTP inhibitory effect of cyclosporin A) binds to FOF1 (F)-ATP synthase, thus
inhibiting its catalytic activity by about 30%. This observation was followed by the demonstration that binding occurs at a
particular subunit of the enzyme, the oligomycin sensitivity conferral protein (OSCP), and that F-ATP synthase can form
Ca2+-activated, high-conductance channels with features matching those of the PTP, suggesting that the latter originates from a
conformational change in F-ATP synthase. This review is specifically focused on the OSCP subunit of F-ATP synthase, whose
unique features make it a potential pharmacological target both for modulation of F-ATP synthase and its transition to a pore
Fast ein Heiliger. Bernhard II. zur Lippe
No full textMeier U. Fast ein Heiliger. Bernhard II. zur Lippe. In: Signori G, ed. Heiliges Westfalen. Heilige, Reliquien, Wallfahrt und Wunder im Mittelalter. Religion in der Geschichte, 11. Bielefeld: Verl. für Regionalgeschichte; 2003: 79-110
Haltern und die Altertumsforschung an der Lippe.
No full textHistorisches und topographisches über die umgebung Halterns. A. Lippe und Steverlauf in früheren jahrhunderten. Von Dr. F. Philippi. B. Der Niemen. Von Dr. F. Philippi. C. War die Lippe im mittelalter ein schiffahrtsweg von erheblicher bedeutung? Von Dr. Th. Ilgen.--Die befestigung auf den hühnenknäppen bei Dollberg. Von Dr. E. Ritterling.--Die römische niederlassung bei Haltern. A. Die anlagen am ufer der Lippe. Von Dr. F. Koepp. B. Die fundstücke. Von Dr. E. Ritterling. C. Das kastell auf dem St. Annaberge. Von Dr. C. Schuchhardt. D. Die Aliso-frag. Von Dr. C. Schuchhardt. E. Vermutungen über die bestimmung und die geschichte der römischen anlagen am Lippeufer bei Haltern. Von Dr. G. Loeschke. F. Nachtrag. Von O. Dahm.Mode of access: Internet
The mitochondrial permeability transition: Recent progress and open questions
No full textMajor progress has been made in defining the basis of the mitochondrial permeability transition, a Ca2+-dependent permeability increase of the inner membrane that has puzzled mitochondrial research for almost 70 years. Initially considered an artefact of limited biological interest by most, over the years the permeability transition has raised to the status of regulator of mitochondrial ion homeostasis and of druggable effector mechanism of cell death. The permeability transition is mediated by opening of channel(s) modulated by matrix cyclophilin D, the permeability transition pore(s) (PTP). The field has received new impulse (a) from the hypothesis that the PTP may originate from a Ca2+-dependent conformational change of F-ATP synthase and (b) from the reevaluation of the long-standing hypothesis that it originates from the adenine nucleotide translocator (ANT). Here, we provide a synthetic account of the structure of ANT and F-ATP synthase to discuss potential and controversial mechanisms through which they may form high-conductance channels; and review some intriguing findings from the wealth of early studies of PTP modulation that still await an explanation. We hope that this review will stimulate new experiments addressing the many outstanding problems, and thus contribute to the eventual solution of the puzzle of the permeability transition
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