1,721,002 research outputs found
Su di un caso di suicidio per autoinoculazione di un farmaco ad azione curarosimile
No full textGli autori descrivono un caso di suicidio posto in atto da un infermiere mediante l'autoinoculazione di farmaco similcurarico, e commentano la connessione tra modalità suicidiaria e disponibilità diel mezzo legata allo status professional
Suicidio mediante assunzione di clorochina: valutazioni medico legali e chimico tossicologiche
No full textGli autori descrivono due casi di intossicazione a scopo suicidiario con clorochina in soggetti extracomunitari. Vengono indicate le metodiche chimico-analitiche utilizzate per il rilievo dell'antimalarico e viene sottolineata la necessità di ampliare il protocollo analitico che includa tale farmaco tra le sostanze di possibile abuso in soggetti extracomunitari
A FATAL KETAMINE POISONING
No full textAn unusual case of death by ketamine overdose is reported. The drug's administration was a homicide for homosexual ends. Authors discuss a rapid and effective solid-phase extraction procedure using Bond-Elute* C18 for Ketamine and Nor-Ketamine detection in biological fluids and tissues with a 75% recovery. The drug analysis was carried out by the means of gas-chromatography (GLC) and gas-chromatography/mass spectrometry (GC-MS). The yield of the procedure for Ketamine was: blood 27.4 mu g/mL; urine 8.51 mu g/mL; bile 15.2 mu g/mL; brain 3.24 mu g/mL; liver 6.6 mu g/mL; kidney 3.38 mu g/mL. Nor-Ketamine was detected in all samples, but not quantified
La diffusione post-mortale di Citalopram: studio di 5 casi
No full textSono stati analizzati 5 casi pervenuti di recente alla nostra osservazione nei quali veniva riscontrata la presenza del Citalopram. Verranno quindi analizzate le concentrazioni tossiche del farmaco in riferimento al range terapeutico e alla luce delle problematiche relative al fenomeno della diffusione post-mortale dello stesso
Un obiettivo primario della Tossicologia Forense: il raggiungimento della qualità - XIV Convegno Nazionale Gruppo Tossicologi Forensi Italiani -SIMLA
No full textGli autori presentano un caso di morte suicidiaria per asfissia da spazio confinato, in cui è stato rilevato il triazolam in concentrazioni sovrapponibili a quelle riferite dalla letteratura internazionale delle intossicazioni acute
9 THC content in illicit cannabis products over the period 1997-2004 (first four months)
Full text linkThe aim of this study is to determine delta 9 tetrahydrocannabinol (delta9 THC) content in 5227 seizures of cannabis products over the period 1997-2004 (first four months). The products were seized in Modena country (Italy). The samples were classified as marijuana and hashish and divided into subgroups. The following results show an increase in the potency (concentration of delta9 THC) of these products
Valutazione della percentuale di d9 THC nelle preparazioni clandestine
No full textIl presente studio ha valutato la percentuale di d9 THC nelle preparazioni di Cannabis sequestrate nel mercato clandestino e giunte all'osservazione nel settorato medio-legale modenese
Aspetti di responsabilità nel settore del doping
No full textaffronta la tematica della responsabilità medica nel settore del dopin
Species Identification Through DNA "Barcodes''
No full textConventional methods for forensic species identification are mainly based on immunological procedures, which have limited applications for old and degraded specimens. The mitochondrial cytochrome b gene sequence has emerged in forensics among molecular methods. Recent investigations in the taxonomic field have suggested that a DNA-based identification system may aid the resolution of animal diversity and classification using sequence analysis and phylogenetic links. Selected gene sequences can be viewed as a genetic "barcode," which is enclosed in every cell, and barcoding is a standardized approach for characterizing species using short DNA sequences as a diagnostic biomarker for organisms. The aim of this study was to evaluate the potential of barcode mitochondrial genes, such as the cytochrome c oxidase sub 1 (COI) and the 16S rRNA gene, as a forensic tool. We developed a new approach for species testing and identification with a singleplex PCR amplification that will be useful not only in criminal casework but also in biosecurity, food authentication, investigation against poaching or illegal trade of endangered species, and wildlife enforcement. Seven fragments ranging from 157 to 541 bp (base pairs) in humans were selected from COI and 16S rRNA genes by different redesigned sets of primers suitable for forensic purposes. The specificity of each primer pair was evaluated with a single PCR reaction on different substrates, and the diversity values were calculated by statistical tests to select a set of markers that could be useful in different caseworks. A case example of forensic species identification is also presented
Zopiclone and prazepam abuse in a chronic migraine patient
Full text linkPainful conditions are frequently accompanied by sleep disorders. Here we present the case, never previously reported, of high doses of zopiclone and prazepam abuse in a patient suffering from migraine and insomnia. A 37-year-old female Caucasian patient, nursing degree, with two 7-year-old twin daughters, began to suffer from migraines in her childhood. Migraine worsened and was associated with insomnia after the daughters’ birth. Eight months ago, migraine and insomnia further worsened in conjunction with the prescription of fluoxetine and prazepam as migraine prophylaxis and of zopiclone for insomnia. From that moment, the patient increased the dose of zopiclone up to 20 tablets (150 mg) nightly and prazepam up to 20 tablets (400 mg) daily. As acute migraine treatment she also used ketorolac 1-2 f every day intramuscularly. The patient was hospitalised for withdrawal of medications and to treat migraine. Hair analysis documented the history of this patient and the good progress of the treatment. Zopiclone and prazepam are considered drugs with low abuse potential. However, the final outcome of a drug treatment may be influenced by non-drug factors, such as the patient’s characteristics and the treatment milieu. In fact, in a stressful context, the prescription of zopiclone in a patient vulnerable for migraine triggered abuse of this drug and of prazepam, which was associated with chronification of migraine and analgesics overuse, without relieving insomnia. In prescribing hypnotics and anxiolytics to patients with chronic pain there must therefore be great caution
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