1,721,218 research outputs found
Le difese dell’apparato respiratorio
No full textIl tessuto respiratorio e altri tessuti mucosi hanno sviluppato caratteristiche immunologiche e strutturali speciali
per la protezione dall’esposizione costante alle sostanze estranee. Le due principali componenti della difesa polmonare contro
l’inalazione di particelle e di altro materiale estraneo sono il sistema di trasporto muco-ciliare, presente nelle grosse vie
aeree, e un sistema immunitario specializzato della mucosa, composto da numerose popolazioni cellulari come cellule dendritiche, macrofagi, linfociti T e B, cellule NK e cellule epiteliali
How to obtain informed consent for research
Full text linkThe process of obtaining informed consent for clinical trials is tightly regulated; complications arise in circumstances when consent may be waived, or when needed from vulnerable populations http://ow.ly/rEMe30j5MVq
Sublingual immunotherapy for pediatric allergic rhinitis: The clinical evidence
Full text linkAllergic rhinitis is estimated to affect 10%-20% of pediatric population and it is caused by the IgE-sensitization to environmental allergens, most importantly grass pollens and house dust mites. Allergic rhinitis can influence patient's daily activity severely and may precede the development of asthma, especially if it is not diagnosed and treated correctly. In addition to subcutaneous immunotherapy, sublingual immunotherapy (SLIT) represents the only treatment being potentially able to cure allergic respiratory diseases, by modulating the immune system activity. This review clearly summarizes and analyzes the available randomized, double-blinded, placebo-controlled trials, which aimed at evaluating the effectiveness and the safety of grass pollen and house dust mite SLIT for the specific treatment of pediatric allergic rhinitis. Our analysis demonstrates the good evidence supporting the efficacy of SLIT for allergic rhinitis to grass pollens in children, whereas trials regarding pediatric allergic rhinitis to house dust mites present lower quality, although several studies supported its usefulness
What's new in pediatric asthma and rhinitis phenotypes and endotypes?
No full textPurpose of review: This review explores the evolving landscape of pediatric asthma and rhinitis, focusing on identifying and characterizing different subtypes. Recent findings: Childhood asthma and rhinitis are prevalent respiratory conditions frequently occurring together. To address the need for a precise definition of these diseases, an unbiased and comprehensive phenotyping approach has been undertaken with hypothesis-free analysis of extensive datasets to uncover new relationships among clinical, environmental, and biological characteristics. On the other hand, the concept of endotype is elaborate and multifaceted, representing distinct pathophysiological mechanisms underlying the clinical presentation and requires the identification of reliable biomarkers. The recognition of multiple inflammatory endotypes underscores the need for in-depth characterization, which could revolutionize the treatment landscape. Summary: Comprehending phenotypes and endotypes is crucial for customizing effective and personalized management approaches for children with asthma and rhinitis. More precise and efficient care can be administered through recognition and detailed characterization, ultimately enhancing patients' quality of life
THE TRANSFORMATIVE POWER OF AI IN PEDIATRIC HEALTHCARE AND ITS APPLICATION IN PEDIATRIC ALLERGY
No full textArtificial intelligence (AI) has a transformative impact on pediatric healthcare, especially in the field of pediatric allergies. This chapter explores how AI enhances the diagnosis, treatment, and prediction of allergic reactions in children. AI’s exceptional ability to analyze multi-dimensional data, detect subtle indicators, and make probabilistic predictions significantly improves diagnostic accuracy and personalization of treatment plans. It also contributes to predicting allergic reactions and developing new therapeutics by identifying novel targets and repurposing existing drugs. While AI presents immense opportunities, challenges such as data privacy, bias, and the need for clinician oversight must be addressed. The chapter emphasizes the importance of responsible AI integration, rigorous validation, and regulatory standards to ensure safe and effective implementation in pediatric allergy care
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